Characterization of Microcellular Biodegradable Polymeric Foams Produced from Supercritical Carbon Dioxide Solutions

Cotugno, S.; Maio, Ernesto Di; Mensitieri, Giuseppe; Iannace, Salvatore; Roberts, George W.; Carbonell, and R. G.; Hopfenberg, H. B.

doi:10.1021/ie049445c

Cited by 55 publications

(37 citation statements)

References 29 publications

(62 reference statements)

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“…Gravimetric techniques that directly follow mass changes with time are frequently used for investigating the sorption kinetics (Chandra and Koros, 2009, Cotugno, 2005. This is more applicable for gases and vapors which are almost condensable.…”

Section: Other Techniques Of Measuringmentioning

confidence: 99%

Diffusion in Polymer Solids and Solutions

Karimi¹

2011

Mass Transfer in Chemical Engineering Processes

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Section: Other Techniques Of Measuringmentioning

confidence: 99%

Diffusion in Polymer Solids and Solutions

Karimi¹

2011

Mass Transfer in Chemical Engineering Processes

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“…The advantage of comparing these two methods of formation is that they are based on two different principles, which are the basis for several other scaffolding methods: In case of FD a polymer solution system is used and in case of PQ a polymer melt system. Poly(e-caprolactone) (PCL) (1) was chosen as the polymeric scaffold material for this study because it has been extensively investigated as a scaffold material (Cotugno et al, 2005;Hou et al, 2003;Kim et al, 2006;Lohfeld et al, 2006;Ng et al, 2001;Serrano et al, 2004;Tang et al, 2004;Xu et al, 2004) and for controlled drug release applications (Pitt, 1990). PCL is well suited for long-term delivery systems such as contraceptives-like Capronor TM , which has a 1-year delivery (Pitt, 1990).…”

Section: Introductionmentioning

confidence: 99%

Formation of poly(ε-caprolactone) scaffolds loaded with small molecules by integrated processes

Luetzow

Klein

Weigel

et al. 2007

Journal of Biomechanics

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Cell stimulation by bioactive molecules has become an important tool in tissue engineering. The homogeneous incorporation of such molecules within the bulk of a polymer-based scaffold compared to surface coating is considered advantageous for most applications and minimizes a burst effect. An efficient way of bulk loading is the incorporation of these molecules during the scaffold formation process. In this paper, two different integrated processes for the preparation of scaffolds from poly(epsilon-caprolactone) (PCL) loaded with a small molecule are investigated. Both formation and loading of the scaffold is carried out in a single-step process. Sudan Red G was selected as a model compound for lipophilic small molecules. A freeze drying and pressure quench (PQ) formation process was selected, and the influence of the small molecule on the formation processes and on the morphology of the obtained scaffold was evaluated and compared. It could be shown for both processes that the formation of loaded scaffolds is possible, and that the small molecule has a very high impact on the foam morphology. In case of the freeze-drying (FD) method, only a load of 1 wt% Sudan Red G was incorporated within the bulk and showed no influence on the foam morphology. In the case of PQ foaming, an incorporation of 43 wt% Sudan Red G was achieved (although tiny crystal needles of the small molecule were found on the surface) and a strong effect on the foam morphology was found. This paper presents an efficient method of incorporating small molecules by integrated processes.

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“…This method has the advantages that CO 2 is cheap, simple to access, gives, for example, a lower dense foam than nitrogen [73,143] and it does not require removal before cell seeding like other pore forming substances. The gas is dissolved in the solid polymer or polymer melt at high temperature and high pressure, for example, for poly(lactide-co-glycolide)acid (PLGA) 35-40°C, 10-20 MPa [153], for poly(ε-caprolactone) (PCL) 70-90°C and 7-32 MPa [154] or even cyclic olefin copolymer (COC) 100-180°C and 30 MPa [155].…”

Section: Scaffold Preparation From the Polymer Melt By A Foaming Processmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

206

154

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Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

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Characterization of Microcellular Biodegradable Polymeric Foams Produced from Supercritical Carbon Dioxide Solutions

Cited by 55 publications

References 29 publications

Diffusion in Polymer Solids and Solutions

Diffusion in Polymer Solids and Solutions

Formation of poly(ε-caprolactone) scaffolds loaded with small molecules by integrated processes

Design and preparation of polymeric scaffolds for tissue engineering

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