Characterization of MICA gene polymorphism of HLA complex in the Slovak population

Ďurmanová, Vladimı́ra; Tirpáková, Jana; Stuchlíková, Martina; Shawkatová, Ivana; Kuba, Daniel; Sapák, Michal; M, Buc

doi:10.3109/03014460.2011.572563

Cited by 10 publications

(6 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to what has been hypothesized for HLA genes , this restricted polymorphism may be due to a genetic bottleneck created by disease outbreak and/or population settlement/migration. MICA*001 , MICA*020 , MICA*045 , and MICA*052 are specific to Europeans , South American Indians , Chinese , and Thais , respectively. The fact that these alleles are abundant just in a specific region of the planet indicates that certain alleles may give rise to more specialized proteins in a given localized microbial environment (although migratory influences could also play a role).…”

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

“…The following populations were included for frequency calculations. MICA : Thailand: Northeastern Thais ; Japan ; China: Li nationality of Southern China , Zhuang nationality of Southern China , Southern Han population , Han population , Northern Han population ; Africa: North Morocco ; Nigerian ; Europe: Southeastern Spain , France , Slovakia , Austria ; South America: Southwest Brazil Amerindians , European Brazilians, Euro‐Brazilian from Parana State, Southeast of Brazil , Sao Paolo , South American Indians ; North America: North American Caucasians , African Americans . MICB : China: Southern Chinese Han , Northern Chinese Han , Zhejiang Han ; Europe: Spain and Wales ; Korea .…”

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

See 1 more Smart Citation

Genetics, genomics, and evolutionary biology of NKG2D ligands

Carapito

Bahram

2015

Immunological Reviews

103

108

View full text Add to dashboard Cite

Human and mouse NKG2D ligands (NKG2DLs) are absent or only poorly expressed by most normal cells but are upregulated by cell stress, hence, alerting the immune system in case of malignancy or infection. Although these ligands are numerous and highly variable (at genetic, genomic, structural, and biochemical levels), they all belong to the major histocompatibility complex class I gene superfamily and bind to a single, invariant, receptor: NKG2D. NKG2D (CD314) is an activating receptor expressed on NK cells and subsets of T cells that have a key role in the recognition and lysis of infected and tumor cells. Here, we review the molecular diversity of NKG2DLs, discuss the increasing appreciation of their roles in a variety of medical conditions, and propose several explanations for the evolutionary force(s) that seem to drive the multiplicity and diversity of NKG2DLs while maintaining their interaction with a single invariant receptor.

show abstract

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

Genetics, genomics, and evolutionary biology of NKG2D ligands

Carapito

Bahram

2015

Immunological Reviews

103

108

View full text Add to dashboard Cite

show abstract

“…The other 27 articles were all full-text. Eight articles were excluded because they did not discuss MICA-TM allele variants 11 12 13 14 15 16 17 18 , two were excluded because they only compared controls 19 20 , and one was excluded because of overlapping patient information with another paper 8 . Finally, 16 publications concerning about the distribution of MICA-TM gene were available for our topic in this meta-analysis 1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 .…”

Section: Resultsmentioning

confidence: 99%

Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis

Zhang

Liao

Yang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

The relationships between polymorphisms of the trans-membrane(TM) region located in the major histocompatibility complex (MHC) class I chain–related gene A (MICA) and Behcet’s disease (BD) have been discussed previously, however, the results were contradictory. In this study, we thoroughly assess whether MICA-TM gene variants are associated with BD by means of a systematic review and meta-analysis. Our study focused on the effects of polymorphisms of MICA-A4, A5, A5.1, A6, and A9 from the included articles. Sixteen previous original publications representing 1,555 BD patients and 2,086 unrelated healthy controls analyzed the association of BD with MICA-TM gene polymorphisms. For the five alleles, MICA-A6 showed a strongly positive correlation with BD patients and could be viewed as an increased risk factor of BD (OR = 2.34, 95%CI: 2.02–2.70). Furthermore, MICA-A4, A5, A5.1, and A9 exhibited negative associations with BD (OR = 0.71, 95%CI: 0.58–0.86; OR = 0.75, 95%CI: 0.63–0.90; OR = 0.63, 95%CI: 0.44–0.91; OR = 0.70, 95%CI: 0.58–0.84, respectively). Our meta-analysis confirmed MICA-A6 could be responsible for BD in three ethnic regions and should probably be treated as a risk factor for BD. MICA-A4, A5, A5.1, and A9 could be regarded as protective factors, especially in the Middle East and East Asia.

show abstract

“…A subset group of MICA alleles contains a frameshift mutation resulting in a premature stop codon and subsequent truncation of the cytoplasmic C-terminus. Interestingly, the MICA allele ∗008 encodes a truncated protein and is the most frequently distributed MICA allele in various populations across the world [32–39]. ULBP1–4 and RAET1 have alpha1 and alpha2 domains similar to MICA/B; however, unlike MICA/B, they do not contain alpha3 domains and their mRNA is expressed at low levels even in normal cells without corresponding surface expression [23, 40].…”

Section: Nk Cells and Activationmentioning

confidence: 99%

Human Herpesviridae Methods of Natural Killer Cell Evasion

Odom

Gaston

Markert

et al. 2012

Advances in Virology

View full text Add to dashboard Cite

Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. These methods include interference with the ligands on infected cell surfaces that bind NK cell activating or inhibitory receptors. This paper summarizes the most extensively studied NK cell receptor/ligand pairs and then describes the methods of NK cell evasion used by all eight herpesviruses through these receptors and ligands. Although great strides have been made in elucidating their mechanisms, there is still a disparity between viruses in the amount of knowledge regarding innate immune evasion. Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.

show abstract

Characterization of MICA gene polymorphism of HLA complex in the Slovak population

Abstract: A comparison of these results with those reported in the literature revealed similarity in MICA polymorphism to that found in other Western Eurasian populations. The data will be useful for further association studies on MICA polymorphism and its function.

Cited by 10 publications

References 45 publications

Genetics, genomics, and evolutionary biology of NKG2D ligands

Genetics, genomics, and evolutionary biology of NKG2D ligands

Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis

Human Herpesviridae Methods of Natural Killer Cell Evasion

Contact Info

Product

Resources

About