Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study

Buscemi, Silvio; Chiarello, Pierfilippo; Buscemi, Carola; Corleo, Davide; Massenti, Maria Fatima; Barile, Anna Maria; Rosafio, Giuseppe; Maniaci, Vincenza; Settipani, Valentina; Cosentino, Loretta; Giordano, Carla

doi:10.1155/2017/9294038

Cited by 44 publications

(50 citation statements)

References 51 publications

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“…The MONW prevalence around the world varies greatly [4,6,13,14,17]. Previous studies have indicated that the global MONW prevalence ranges from as low as 5% to as high as 45%.…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, the prevention and control of obesity is key to controlling the epidemics of common chronic diseases. Previous studies have indicated that obesity is a heterogeneous disease in terms of body shapes ("apple" and "pear" shapes), pathologic types of lipocytes (hyperplasia and hypertrophy) and metabolic status (metabolically normal obesity and metabolically abnormal obesity) [4]. Obese individuals with an "apple shape," hypertrophy, or metabolic abnormality have higher risk for adverse outcomes [4,5].…”

mentioning

confidence: 99%

“…On the other hand, not all individuals with normalweight are metabolically normal. Some normal-weight individuals also have multiple cardio-metabolic disorders such as insulin resistance, and high levels of inflammation, triglycerides (TG), blood pressure (BP), fasting plasma glucose (FPG), and decreased high-density lipoprotein cholesterol (HDL-C) [4], These individuals are typically referred to as metabolically obese but normalweight (MONW) [6,7]. Kramer, et al [8] reported that MONW was associated with an increased risk of cardiovascular disease and all-cause mortality.…”

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confidence: 99%

“…Previous studies revealed that the global prevalence of MONW varied from 5 to 45% [4,13]. This variation may be due to individuals' age, gender, ethnicity, and geographic location, and variation in MONW definitions (i.e., different criteria on obesity and metabolic abnormality).…”

mentioning

confidence: 99%

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Prevalence and epidemiological determinants of metabolically obese but normal-weight in Chinese population

Zheng¹,

Lin²,

Liu³

et al. 2020

BMC Public Health

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Background: There is metabolic heterogeneity in normal-weight individuals, however, there has been limited research in the Chinese population. This study aimed to investigate the prevalence, distribution and epidemiological determinants of metabolically obese but normal-weight (MONW) in a Chinese population. Methods: A total of 17,876 normal-weight individuals were recruited from 37,815 individuals in Zhejiang province in southeastern China. Normal-weight was defined as a body mass index (BMI) of 18.5-23.9 kg/m 2 . Metabolically abnormal traits were assessed by metabolic syndrome criteria from the International Diabetes Federation (IDF) in 2015. MONW was defined as individuals who had at least two metabolically abnormal trait but normal weight. Multiple logistic regression was used to investigate MONW risk factors, adjusting for potential confounders. Results: The prevalence of metabolic abnormality was 34.1% in normal-weight individuals, and the overall prevalence of MONW was 16.1% in the general population. Different MONW distributions were found between men and women depending on age. Compared with women, men had a significantly higher MONW prevalence among those aged < 45 years old, and there was a lower prevalence for those aged ≥50 years old. Higher BMI or waist circumference (WC), central obesity, menopause, and family histories of hypertension, diabetes, and cardiovascular diseases, increased MONW risk. Higher education levels, regular alcohol drinking, and balanced or vegetarian food preferences reduced MONW risk.Conclusions: Normal-weight individuals have metabolic heterogeneity in China. The MONW distribution between men and women depends on age. BMI, WC, dietary factors, and family history of chronic diseases, are associated with metabolic status.

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“…The MONW prevalence around the world varies greatly [4,6,13,14,17]. Previous studies have indicated that the global MONW prevalence ranges from as low as 5% to as high as 45%.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Prevalence and epidemiological determinants of metabolically obese but normal-weight in Chinese population

Zheng¹,

Lin²,

Liu³

et al. 2020

BMC Public Health

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“…6 Interestingly, not all obese subjects develop the metabolic abnormalities associated with obesity. 7 This protection has been associated with an increased adipose tissue expandability in some subjects. 8 Nevertheless, adipose tissue of those metabolically healthy obese subjects becomes dysfunctional over time and the metabolic alterations appear, 9 however the precise mechanisms leading to adipose dysfunction during obesity are not completely elucidated.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin synthesis and secretion by subcutaneous adipose tissue is impaired during obesity by endoplasmic reticulum stress

Torre‐Villalvazo

Bunt²,

Alemán³

et al. 2018

J of Cellular Biochemistry

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Subcutaneous (SAT) and visceral (VAT) adipose tissues stores excess energy as triglycerides and synthesize adiponectin to prevent ectopic lipid accumulation and lipotoxicity. During obesity, an impairment in the capacity of SAT to store triglycerides and synthesize adiponectin is associated with increased free fatty acids (FFA) release, leading to VAT hypertrophy and hepatic and skeletal muscle lipotoxicity. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may be involved in SAT dysfunction during obesity. The objectives of this study were to assess UPR activation and adiponectin synthesis in: 1) SAT and VAT from mice exposed to acute pharmacologic or chronic obesity-induced ER stress and in 2) cultured mice primary mature adipocytes or adipocytes differentiated in vitro from SAT and VAT exposed to tunicamycin or thapsigargin. Mice fed a high-fat diet developed obesity, increased FFA and lower circulating adiponectin in association with lower adiponectin synthesis and increased UPR markers in SAT. Mice subjected to acute ER stress by pioglitazone administration and a low-dose tunicamycin injection presented a maladaptive UPR activation in SAT along with reduced adiponectin synthesis and secretion and increased lipolysis with respect to VAT, associated with lipid accumulation in skeletal muscle and liver. Primary adipocytes and adipocytes differentiated from SAT exposed to pharmacologic ER stress also developed maladaptive UPR, along with reduced adiponectin synthesis and increased lipolysis with respect to those from VAT. Our results indicate that compared to VAT, SAT is more susceptible to ER stress, leading to increased lipolysis and reduced adiponectin synthesis and secretion.

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Not So Normal Unhealthy Lean

Wijayatunga

Fernández-del-Valle

2023

The Active Female

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Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study

Cited by 44 publications

References 51 publications

Prevalence and epidemiological determinants of metabolically obese but normal-weight in Chinese population

Prevalence and epidemiological determinants of metabolically obese but normal-weight in Chinese population

Adiponectin synthesis and secretion by subcutaneous adipose tissue is impaired during obesity by endoplasmic reticulum stress

Not So Normal Unhealthy Lean

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