Abstract:The L-site binding of ferricytochrome c to cardiolipin (CL) -containing liposomes at slightly acidic pH has attracted interest owing to its potential role in converting this classical electron transfer protein into a peroxidase. Various lines of evidence presented by Nantes and coworkers suggest that this mode of binding is electrostatic, active below pH 7, and involves residues K22, K25, and K27 as well as H26 and H33. We combined several spectroscopic techniques to characterize L-site binding thermodynamical… Show more
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