Characterization of mediastinal lymphadenopathy with diffusion-weighted imaging

Does steatosis affect the performance of diffusion-weighted MRI values for fibrosis evaluation in patients with chronic hepatitis C genotype 4?

“…In addition, METAVIR is not a continuous scale, and the increased accumulation of fibrous tissue upon different stages of fibrosis is not linear (34). Third, this study performed DW-MRI of the liver; however, future studies using diffusion tensor MRI and MR spectroscopy will achieve better results (35)(36)(37).…”

Diffusion-weighted MR imaging of mediastinal lymphadenopathy in children

“…Malignant nodes commonly appear hypointense whereas benign nodes appear hyperintense on ADC maps; however, mixed signal intensities may be obtained for malignant and benign nodes [19]. The mean ADC value for malignant mediastinal lymphadenopathy (1.06 ± 0.3 × 10 −3 mm 2 /s) is significantly (P = 0.001) lower than that for benign lymphadenopathy (2.39 ± 0.7 × 10 −3 mm 2 /s) in images obtained from adult patients and use of b values of 0 and 600 s/mm 2 [20]. These ADC values are significant for detection of malignant lymph nodes, both enlarged mediastinal lymph nodes (P < 0.001) and normal lymph nodes (P < 0.001) [27].…”

“…There have been a few limited studies on diffusionweighted MR imaging of mediastinal masses [17,18] and lymph nodes in adults [19,20]. Mean ADC values for adult malignant mediastinal tumors are significantly lower than for benign tumors.…”

“…In another study of adult patients with mediastinal lymphadenopathy [20], an ADC value of 1.85 × 10 −3 mm 2 /s was used as a threshold to differentiate malignant from benign lymphadenopathy. The promising result in our study is different from other literature results [20].…”

“…[17,18]. Diffusion-weighted MR imaging has also been used for characterization of mediastinal [19,20], abdominal [21], neck [22], and axillary [23] lymph nodes. Diffusion-weighted MR imaging has been used for evaluation of mediastinal [24], abdominal [25], and neck masses [26] in children.…”