Characterization of Mapuera virus: structure, proteins and nucleotide sequence of the gene encoding the nucleocapsid protein

Henderson, Gordon W.; Laird, Charles D.; Dermott, Evelyn; Rima, Bertus K.

doi:10.1099/0022-1317-76-10-2509

Cited by 26 publications

(19 citation statements)

References 35 publications

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“…1970) and Kyasanur Forest (Pavri and Singh 1968), and with two unidentified paramyxoviruses (Pavri et al . 1971; Henderson et al . 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Of the two paramyxoviruses, one was isolated from a Rousette fruit bat ( Rousettus leschenaulti ) in India (Pavri et al. 1971) and was later identified as a new animal subtype of parainfluenza virus (PIV) type 2, and the other, Mapuera virus, a member of the genus Rubulavirus, was isolated from a Yellow‐shouldered bat ( Sturnira lilium ) captured in the tropical rain forest of Brazil in 1979 (Henderson et al . 1995).…”

Section: Introductionmentioning

confidence: 99%

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Managing emerging diseases borne by fruit bats (flying foxes), with particular reference to henipaviruses and Australian bat lyssavirus

Mackenzie

Field

Guyatt

2003

Journal of Applied Microbiology

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Since 1994, a number of novel viruses have been described from bats in Australia and Malaysia, particularly from fruit bats belonging to the genus Pteropus (flying foxes), and it is probable that related viruses will be found in other countries across the geographical range of other members of the genus. These viruses include Hendra and Nipah viruses, members of a new genus, Henipaviruses, within the family Paramyxoviridae; Menangle and Tioman viruses, new members of the Rubulavirus genus within the Paramyxoviridae; and Australian bat lyssavirus (ABLV), a member of the Lyssavirus genus in the family Rhabdoviridae. All but Tioman virus are known to be associated with human and/or livestock diseases. The isolation, disease associations and biological properties of the viruses are described, and are used as the basis for developing management strategies for disease prevention or control. These strategies are directed largely at disease minimization through good farm management practices, reducing the potential for exposure to flying foxes, and better disease recognition and diagnosis, and for ABLV specifically, the use of rabies vaccine for pre- and post-exposure prophylaxis. Finally, an intriguing and long-term strategy is that of wildlife immunization through plant-derived vaccination.

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“…1970) and Kyasanur Forest (Pavri and Singh 1968), and with two unidentified paramyxoviruses (Pavri et al . 1971; Henderson et al . 1995).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Managing emerging diseases borne by fruit bats (flying foxes), with particular reference to henipaviruses and Australian bat lyssavirus

Mackenzie

Field

Guyatt

2003

Journal of Applied Microbiology

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“…The MaV N gene sequence has already been published (Henderson et al, 1995). Since bats are believed to be a natural host of HeV, we were interested to see if MaV and HeV share any unique features that may be related to host specificity.…”

Section: Morbillivirus Paramyxovirus Rubulavirusmentioning

confidence: 99%

Sequence analysis of the Hendra virus nucleoprotein gene: comparison with other members of the subfamily Paramyxovirinae.

Hansson

Shiell

et al. 1998

Journal of General Virology

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The nucleoprotein (N) gene of Hendra virus (HeV), an unclassified member of subfamily Paramyxovirinae in the family Paramyxoviridae previously known as equine morbillivirus, was cloned and sequenced. The majority of the deduced amino acid sequence was further confirmed by direct sequencing of peptide fragments of the N protein derived from purified virions. The 3h untranslated sequence of the HeV N gene mRNA was 568 nt and was much longer than that observed in other Paramyxovirinae. The N protein was 532 amino acids in length with a molecular mass of 58n5 kDa. Although the HeV N protein had a slightly higher amino acid sequence identity to those of the genus Morbillivirus than to those of other Paramyxovirinae genera, the level of identity was much lower than that observed within the morbilliviruses. Our results indicated that HeV could not confidently be classified as a member of the genus Morbillivirus, Paramyxovirus or Rubulavirus and suggest that the virus be classified in a new genus within the Paramyxovirinae.

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“…PIV5 strain W3A (Choppin, 1964), rPIV5VΔC (He et al , 2002) and MPRV strain BeAnn 370284 (Henderson et al , 1995) were grown and titrated in Vero cells. For virus infections, cell monolayers were incubated for 90 min with an appropriate dilution of virus stock in serum-free Dulbecco's modified Eagle's medium.…”

Section: Methodsmentioning

confidence: 99%

Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs

Hagmaier

Stock

Precious

et al. 2007

Journal of General Virology

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Mapuera virus (MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genus Rubulavirus on the basis of structural and genetic features. Like other rubulaviruses it encodes a V protein (MPRV/V) that functions as an interferon (IFN) antagonist. Here we show that MPRV/V differs from the IFN antagonists of other rubulaviruses in that it does not induce the proteasomal degradation of STAT proteins, key factors in the IFN signalling cascade. Rather, MPRV/V prevents the nuclear translocation of STATs in response to IFN stimulation and inhibits the formation of the transcription factor complex ISGF3. We also show that MPRV/V blocks IFN signalling in cells from diverse mammalian species and discuss the IFN response as a barrier to cross-species infections.

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Characterization of Mapuera virus: structure, proteins and nucleotide sequence of the gene encoding the nucleocapsid protein

Cited by 26 publications

References 35 publications

Managing emerging diseases borne by fruit bats (flying foxes), with particular reference to henipaviruses and Australian bat lyssavirus

Managing emerging diseases borne by fruit bats (flying foxes), with particular reference to henipaviruses and Australian bat lyssavirus

Sequence analysis of the Hendra virus nucleoprotein gene: comparison with other members of the subfamily Paramyxovirinae.

Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs

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