Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

Urano, Makoto; Nagao, Toshitaka; Miyabe, Satoru; Ishibashi, Kenichiro; Higuchi, Kayoko; Kuroda, Makoto

doi:10.1016/j.humpath.2014.09.012

Cited by 94 publications

(91 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Parenthetically, before this paper, only 10 lowgrade salivary duct carcinomas, to our knowledge, have been tested for the ETV6 rearrangement; all have been negative. 1,[3][4][5][6]37 Low-grade salivary duct carcinoma 9,10 is a rare neoplasm resembling low-grade cribriform ductal carcinoma in situ of the breast. It is characterized by intraductal proliferation of low-grade ductal cells 9 No recurrences have been reported to date.…”

Section: Discussionmentioning

confidence: 99%

Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study

et al. 2015

View full text Add to dashboard Cite

Mammary analog secretory carcinoma (MASC) is a recently recognized low-grade salivary carcinoma characterized by a specific ETV6 rearrangement. We describe 14 new MASCs and examine their immunophenotypic and genetic profiles in the context of look-alikes, namely, low-and high-grade salivary duct carcinoma and acinic cell carcinoma. ETV6 rearrangement, and robust expression of mammaglobin and S100, were demonstrated in 11/11, 14/14, and 12/14 MASCs, respectively. All low-grade salivary duct carcinomas coexpressed S100/mammaglobin (6/6); none harbored ETV6 rearrangements (0/5). Given that S100/mammaglobin coexpression and absence of zymogen granules are features of both MASC and low-grade salivary duct carcinoma, these two are best distinguished histologically. The former is predominantly an extraductal neoplasm with bubbly pink cytoplasm, whereas the latter is a distinct intraductal micropapillary and cribriform process. Querying ETV6 gene status may be necessary for difficult cases. No acinic cell carcinoma expressed mammaglobin (0/13) or harbored an ETV6 rearrangement (0/7); only 1/13 acinic cell carcinomas weakly expressed S100. DOG1 expression was limited or absent among all tumor types, except acinic cell carcinoma which expressed DOG1 diffusely in a canalicular pattern. Therefore, histology and immunohistochemistry (mammaglobin, S100, DOG1) suffices in distinguishing acinic cell carcinoma from both MASC and low-grade salivary duct carcinoma. HER2 (ERBB2) amplification was detected in only 1/10 acinic cell carcinomas, but none of the MASCs or low-grade salivary duct carcinomas tested. High-grade salivary duct carcinomas frequently expressed mammaglobin (11/18) and harbored HER2 amplifications (13/15); none harbored ETV6 rearrangements (0/12). High-grade salivary duct carcinomas can easily be distinguished from these other entities by histology and HER2 amplification.

show abstract

Section: Discussionmentioning

confidence: 99%

Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…There have been 11 reported cases in patients under 18 years of age [6,13,26,[29][30][31][32][33][34][35][36]. One of our cases with rearranged ETV6 involved a 12-year-old female making this the youngest reported MASC in literature.…”

mentioning

confidence: 81%

“…It was first described as a calcium-activated chloride channel in 2008 and is routinely used in the diagnosis of gastrointestinal stromal tumours (GIST) [10][11][12][13][14][15][16]. Its expression pattern in salivary gland neoplasms is not well established although a recent study showed expression in acinar lumens in both normal glands and ACC [13].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands

Khurram¹,

Sultan-Khan²,

Atkey

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

“…Serous acinar cells containing zymogen granules are only found in ACC and thus characterize this tumor. However, the zymogen granules can be infrequent and difficult to detect (zymogen granule-poor ACC) even when PAS staining after diastase digestion is used for granule identification [3]. This type of ACC, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…The ETV6 translocation detected by fluorescence in situ hybridization (FISH) is the criterion standard for the definitive diagnosis of MASC. As this method is not available in many laboratories, immunohistochemical markers have been used to distinguish MASC from ACC in an attempt to reduce the dependence on molecular genetic tests [2][3][4][7][8][9][10][11][12][13][14][15]. Expression of mammaglobin and S-100 along with absence of reactivity for DOG1 (a molecular component of Ca2?…”

Section: Introductionmentioning

confidence: 99%

Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands

Mariano

Gómez

Nascimento

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

Lysozyme is an enzymatic marker of acinar and intercalated duct cells of normal salivary glands. The aim of this study was to verify whether lysozyme expression could be useful to distinguish acinic cell carcinoma (ACC) from its main mimic, mammary analog secretory carcinoma (MASC). For comparison, DOG1 expression was analyzed as well. Seventeen cases of ACC, 15 MASC, and 125 other salivary tumors were studied. Lysozyme expression was found in tumor cells as well as in secreted material of MASC (86.6 % of cases) and in ductal cells of epithelial-myoepithelial carcinoma (EMC-53.8 %), pleomorphic adenoma (PA-29.1 %) and polymorphous lowgrade adenocarcinoma (PLGA-23.8 %). However, in ACC, lysozyme was not expressed. Three patterns of DOG1 staining were seen: apical-luminal, cytoplasmic, and mixed cytoplasmic/membranous. The apical-luminal pattern was detected in ductal cells of ACC (58.8 % of cases), EMC (38.4 %), adenoid-cystic carcinoma (AdCC-35.3 %), PA (8.3 %), and PLGA (4.8 %). These tumors also showed mixed membranous/cytoplasmic staining for DOG1. MASC, mucoepidermoid, and salivary duct carcinomas exhibited only DOG1 cytoplasmic staining. In conclusion, lysozyme cannot be used as a marker of acinar differentiation in salivary tumors. However, lysozyme expression can be helpful to distinguish MASC from ACC due to its high frequency in the former and absence in ACC. It is likely that in MASC, lysozyme expression may reflect a lactational-like secretory differentiation since lysozyme belongs to breast milk proteins. Regarding DOG1 expression, the apical-luminal pattern is related to acinar and intercalated duct differentiation whereas the cytoplasmic staining does not seem to be associated with a specific cellular phenotype.

show abstract

Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

Cited by 94 publications

References 31 publications

Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study

Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study

Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands

Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands

Contact Info

Product

Resources

About