Characterization of Male OF1cenp Mice with Age-Induced Cognitive Decline

Abstract

Age is the greatest risk factor for memory loss and other disorders. The aim of this paper was to investigate whether the OF1 cenp mouse was suitable for use as a model of age-induced cognitive decline. To achieve this, it was compared male OF1 cenp middle aged and aged with young mice for learning abilities and biochemical markers. It was obtained that based on the different mechanisms of memory that was evaluated in the Y-maze test, in the Morris Water Maze and in the Novel Object Task, it can be affirmed that aged male OF1 cenp mice from 7-8 months show true cognitive deficits based in the reduction of learning and memory. It was found an increase in glucose, triglycerides and cholesterol concentration in the aged mice. At the age of 7-8 and 15-16 months, a significant decrease in the size of the brain was obtained, on the contrary the liver weight does not show differences. An increase in oxidative damage and a decrease in the antioxidant total capacity in the brains of aged animals was also found in relation to young animals. The correlation of results obtained in relation to behavioral task, hematological and biochemical analyses indicate that OF1 cenp mice with 15-16 months of age are a useful model cognitive decline. It can be used to characterize this disorder during aging and evaluate nutritional supplements for its prevention.