Characterization of Lymphocytic Infiltrates inHelicobacter pylori-Associated Gastritis

Abstract

Selective expansion of CD4+, CD45RO+ memory-type T cells could reflect an antigen-specific and/or chemokine-mediated effect in HAG. Locally produced CC chemokines such as RANTES have been detected in HAG.

Chemokine Receptor 5 Expression in Gastric Mucosa ofHelicobacter pylori-Infected and Noninfected Children

“…A slight but nonsignificant increase in the CD4/CD8 ratio was observed in infected gastric mucosa. This finding is in line with the findings of Hatz et al (19) but contradicts those of other studies in which significant increases in the numbers of T cells (24) or CD8 ϩ cells (20) were found in H. pylori-infected mucosa. In contrast, the numbers of lamina propria CD4 ϩ and CD8 ϩ T cells increased significantly during H. pylori infection, with a consistent predominance of CD4 ϩ cells, corresponding to the findings of Hatz et al (19).…”

“…This finding is in line with the findings of Hatz et al (19) but contradicts those of other studies in which significant increases in the numbers of T cells (24) or CD8 ϩ cells (20) were found in H. pylori-infected mucosa. In contrast, the numbers of lamina propria CD4 ϩ and CD8 ϩ T cells increased significantly during H. pylori infection, with a consistent predominance of CD4 ϩ cells, corresponding to the findings of Hatz et al (19). The CD4/CD8 ratio was not significantly different among the groups, in contrast to studies that reported a selective enrichment of CD4 ϩ cells (40) or CD8 ϩ cells (20) in infected individuals.…”

Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation

“…Active chronic gastritis due to Helicobacter pylori infection is characterized by the infiltration of inflammatory cells such as neutrophils, lymphocytes, and eosinophils into the gastric mucosa [1][2][3]. Levels of infiltrating eosinophils decrease slowly and remain elevated even 1 year after H. pylori is eradicated [2].…”

Helicobacter pyloriStimulates Dendritic Cells To Induce Interleukin-17 Expression from CD4+T Lymphocytes

“…CD4 ϩ T cells were selected, as they represent the predominant component of the gastric infiltrates following H. pylori infection of humans and animal models (16,17,29,45). ICS showed that both IL-17 and IFN-␥ were detectable in CD4 ϩ T cells stimulated for 5 days with H. pylori-infected DCs (Fig.…”

“…H. pylori infection of gastric mucosa leads to active chronic inflammation characterized by both a lymphocytic and neutrophil infiltrate with the induction of proinflammatory cytokines, mainly interleukin-1␤ (IL-1␤), tumor necrosis factor alpha (TNF-␣), IL-8, and IL-6 (13,29).…”