Characterization of low-density lipoprotein subclasses in children

Arisaka, Osamu; Fujiwara, Sachi; Yabuta, Keijiro; Mikami, Hiroshi; Mitugi, Yasushi; Miyake, Noriko

doi:10.1016/s0026-0495(97)90292-4

Cited by 27 publications

(29 citation statements)

References 16 publications

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“…The prevalence of a pattern B phenotype is low in both young males and pre-menopausal females 12,13) . This is consistent with data showing the prevalence of pattern B in samples of children to be 9.3%, 7.5%, 8.2%, 11%, 7.8 [14][15][16][17][18] . In these studies there was a propensity of those with pattern B to be more overweight than those categorised to pattern A.…”

Section: Introductionsupporting

confidence: 92%

Low-Density Lipoprotein Sub-Fraction Profiles in Obese Children Before and After Attending a Residential Weight Loss Intervention

King

Hobkirk

Cooke

et al. 2008

JAT

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Section: Introductionsupporting

confidence: 92%

Low-Density Lipoprotein Sub-Fraction Profiles in Obese Children Before and After Attending a Residential Weight Loss Intervention

King

Hobkirk

Cooke

et al. 2008

JAT

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“…In the present study, we found that the prevalence of sdLDL in obese children was higher than that reported in the Japanese general pediatric population (Arisaka et al, 1997;Shimabukuro et al, 2004), and also found a relationship of peak LDL diameter with abdominal fat accumulation and TG. These results suggest that children with sdLDL already exhibit some features that are usually associated with the metabolic syndrome.…”

Section: Discussionsupporting

confidence: 48%

“…The formation of sdLDL may be affected not only by genetic factors but also by environmental factors (Austin, 1994;Arisaka et al, 1997). In the Framingham Study, 15% of the population showed a change in LDL subclass over 3 years (44% from pattern B to A, 56% from pattern A to B), which supported the existence of a strong environmental component (McNamara et al, 1992).…”

Section: Discussionmentioning

confidence: 90%

“…Therefore, high fat intake was suspected to have played a role in the formation of sdLDL in our study. Body fat accumulation also affects LDL particle size, even in children (Arisaka et al, 1997;Kuromori et al, 2002;Shimabukuro et al, 2004). Especially abdominal adiposity is reported to be associated with sdLDL in healthy men (Lemieux et al, 2000), men with glucose intolerance (Suehiro et al, 1995) and obese children (Kang et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, FCHL patients may have a genetic predisposition to the formation of sdLDL. However, information about sdLDL and its relationship with obesity or FCHL in children is limited (Arisaka et al, 1997;Freedman et al, 2000;Shimabukuro et al, 2004). The aim of the present study was (i) to determine the prevalence of sdLDL in obese children, and (ii) to investigate its relationship with anthropometric and metabolic variables.…”

Section: Introductionmentioning

confidence: 95%

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LDL particle size, fat distribution and insulin resistance in obese children

et al. 2005

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Background: The importance of small dense low-density lipoprotein (sdLDL) cholesterol in coronary heart disease has been demonstrated in many studies. Body fat accumulation, especially abdominal adiposity, is one of the important factors modifying the expression of sdLDL in adults. Objective: To determine the prevalence of sdLDL in obese children, and to investigate its relationship with anthropometric and metabolic variables. Subjects: A total of 30 obese children (22 males, 8 females) aged 12.670.6 years (mean7s.e.), who presented to our outpatient clinic with obesity. Methods: LDL peak particle diameter was determined using gel electrophoresis. LDL subclasses were classified into sdLDL (pattern B; diametero25.5 nm) and non-sdLDL (pattern A; diameterX25.5 nm). Anthropometric and metabolic variables were also determined to identify factors modifying LDL particle size. Results: sdLDL was detected in 11 children (40.0%). In children with sdLDL, waist/height ratio was significantly higher (P ¼ 0.0466), and they had significantly higher triglyceride (TG) (P ¼ 0.0035) and lower high-density lipoprotein cholesterol (HDLC) levels (P ¼ 0.036). Peak LDL diameter as a continuous variable was significantly correlated with HDLC and TG levels. In multiple regression analysis, body mass index and waist/height ratio were significant determinants of the peak LDL diameter variability. Conclusions: We found a high prevalence of sdLDL in obese children, and a relationship of peak LDL diameter with abdominal fat accumulation, HDLC and TG levels. The presence of sdLDL might be an important risk factor for the metabolic syndrome.

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Liprotein(a) Phenotypes in Japanese Children: A Cohort Study

Arisaka,

Fujiwara,

Miyake

et al. 1997

J. pediatr. gastroenterol. nutr.

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Background:Elevated serum lipoprotein(a) [Lp(a)] concentrations have been demonstrated to be associated with cardiovascular diseases due to premature atherosclerosis. However, the association of Lp(a) phenotypes with the development of these diseases remains largely unexplored.Methods:We analyzed the population‐based frequencies of serum Lp(a) phenotypes in 269 Japanese children aged 8‐13 years in one community. According to the different apolipoprotein(a) [apo(a)] electrophoretic mobilities, Lp(a) was classified into seven single‐band and respective double‐band phenotypes. Each individual expressed a single (homozygotic) or a double band (heterozygotic).Results:The serum Lp(a) concentration frequency distribution was skewed toward lower levels with a mean ± SD of 15.5 ± 18.0 mg/dl and a median of 11.0 mg/dl. The Lp(a) phenotype frequencies revealed that the frequency of double‐band phenotype expression (55%) was higher than that of single bands (44%) and that the frequency of phenotypes representative of low molecular weight apo(a) was very low (2%). The mean serum Lp(a) concentration of the double‐band‐expressing subjects was higher than that of subjects with the single‐band phenotype (20.1 ± 19.9 vs. 10.5 ± 15.9 mg/dl, p < 0.01).Conclusions:These findings of Lp(a) phenotypes in children seemed to differ from those in Japanese adults in another study; contrary to expectation, the predominant Lp(a) phenotypes found in children were those frequently associated with cardiovascular diseases in adults. Thus, it is speculated that children whose Lp(a) phenotypes remain unchanged during the transition to adulthood may show an increased susceptibility to cardiovascular disease, although the nutritional effects on the Lp(a) phenotypes cannot be neglected.

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Characterization of low-density lipoprotein subclasses in children

Cited by 27 publications

References 16 publications

Low-Density Lipoprotein Sub-Fraction Profiles in Obese Children Before and After Attending a Residential Weight Loss Intervention

Low-Density Lipoprotein Sub-Fraction Profiles in Obese Children Before and After Attending a Residential Weight Loss Intervention

LDL particle size, fat distribution and insulin resistance in obese children

Liprotein(a) Phenotypes in Japanese Children: A Cohort Study

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