Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Heiland, Dieter Henrik; Ohle, Robin; Cipriani, Debora; Franco, Pamela; Delev, Daniel; Behriger, Simon P.; Kellner, Elias; Petrova, Gergana; Neidert, Nicolas; Mader, Irina; Nuñez, Mateo Fariña; Urbach, Horst; Sankowski, Roman; Beck, Jürgen; Schnell, Oliver

doi:10.1186/s12885-020-07290-6

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Diagnosis of GBM was based on the 2016 WHO Classification of Tumors of the Central Nervous System (17). Specimens were analyzed using the standard protocol at the Institute of Neuropathology, Medical Center-University of Freiburg as described in previous publications (17)(18)(19). IDH mutations were detected by immunohistochemistry (IHC).…”

Section: Histopathological and Molecular Analysismentioning

confidence: 99%

Hydrocephalus Shunting in Supratentorial Glioblastoma: Functional Outcomes and Management

et al. 2022

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BackgroundGlioblastoma is the most common and the most challenging to treat adult primary central nervous system tumor. Although modern management strategies modestly improved the overall survival, the prognosis remains dismal associated with poor life quality and the clinical course often dotted by treatment side effects and cognitive decline. Functional deterioration might be caused by obstructive or communicating hydrocephalus but due to poor overall prognosis surgical treatment options are often limited and its optimal management strategies remain elusive. We aimed to investigate risk factors, treatment options and outcomes for tumor-associated hydrocephalus in a contemporary 10 years cohort of glioblastoma patients.MethodsWe reviewed electronic health records of 1800 glioblastoma patients operated at the Department of Neurosurgery, Medical Center – University of Freiburg from 2009 to 2019. Demographics, clinical characteristics and radiological features were analyzed. Univariate analysis for nominal variables was performed either by Fisher’s exact test or Chi-square test, as appropriate.ResultsWe identified 39 glioblastoma patients with symptomatic communicating hydrocephalus treated by ventricular shunting (incidence 2.1%). Opening of the ventricular system during a previous tumor resection was associated with symptomatic hydrocephalus (p<0.05). There was also a trend toward location (frontal and temporal) and larger tumor volume. Number of craniotomies before shunting was not considered as a risk factor. Shunting improved hydrocephalus symptoms in 95% of the patients and Karnofsky Performance Score (KPS) could be restored after shunting. Of note, 75% of the patients had a post-shunting oncological treatment such as radiotherapy or chemotherapy, most prevalently chemotherapy. Infection (7.7%) and over- or under drainage (17.9%) were the most common complications requiring shunt revision in ten patients (25.6%), No peritoneal metastasis was found. The median overall survival (OS) was 385 days and the median post shunting survival was 135 days.ConclusionVentricular system opening was identified as a risk factor for communicating hydrocephalus in glioblastoma patients. Although glioblastoma treatment remains challenging, shunting improved hydrocephalus-related functional status and may be considered even in a palliative setting for symptom relief.

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Section: Histopathological and Molecular Analysismentioning

confidence: 99%

Hydrocephalus Shunting in Supratentorial Glioblastoma: Functional Outcomes and Management

et al. 2022

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“…Specimens were fixed in 4% phosphate-buffered formaldehyde and paraffin-embedded according to standard procedures in the Institute of Neuropathology, Medical Center-University of Freiburg, as detailed described in our previous works [ 16 , 17 ]. In order to determine the IDH mutation status, we performed IHC (R132H).…”

Section: Methodsmentioning

confidence: 98%

Surgery for IDH1/2 wild-type glioma invading the corpus callosum

et al. 2020

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Background Glioblastoma of the corpus callosum (ccGBM) are rare tumors, with a dismal prognosis marked by a rapid clinical deterioration. For a long time, surgical treatment was not considered beneficial for most patients with such tumors. Recent studies claimed an improved survival for patients undergoing extensive resection, albeit without integration of the molecular profile of the lesions. The purpose of this study was to investigate the effect of biopsy and surgical resection on oncological and functional outcomes in patients with IDH wild-type ccGBM. Methods We performed a retrospective analysis of our institution’s database of patients having been treated for high-grade glioma between 2005 and 2017. Inclusion criteria were defined as follows: patients older than 18 years, histopathological, and molecularly defined IDH wild-type glioma, major tumor mass (at least 2/3) invading the corpus callosum in the sagittal plane with a uni- or bilateral infiltration of the adjacent lobules. Surgical therapy (resection vs. biopsy), extent of resection according to the remaining tumor volume and adjuvant treatment as well as overall survival and functional outcome using the Karnofsky Performance Score (KPS) were analyzed. Results Fifty-five patients were included in the study, from which the mean age was 64 years and men (n = 34, 61.8%) were more often affected than women (n = 21, 38.2%). Thirty (54.5%) patients were treated with stereotactic biopsy alone, while 25 patients received tumor resection resulting in 14.5% (n = 8) gross-total resections and 30.9% (n = 17) partial resections. The 2-year survival rate after resection was 30% compared to 7% after biopsy (p = 0.047). The major benefit was achieved in the group with gross-total resection, while partial resection failed to improve survival. Neurological outcome measured by KPS did not differ between both groups either pre- or postoperatively. Conclusions Our study suggests that in patients with corpus callosum glioblastoma, gross-total resection prolongs survival without negatively impacting neurological outcome as compared to biopsy.

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Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Cited by 2 publications

References 18 publications

Hydrocephalus Shunting in Supratentorial Glioblastoma: Functional Outcomes and Management

Hydrocephalus Shunting in Supratentorial Glioblastoma: Functional Outcomes and Management

Surgery for IDH1/2 wild-type glioma invading the corpus callosum

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