Characterization of long COVID-19 manifestations and its associated factors: A prospective cohort study from Iran

Larijani, Mona Sadat; Ashrafian, Fatemeh; Amiri, Fatemeh; Banifazl, Mohammad; Bavand, Anahita; Karami, Afsaneh; Shokooh, Fatemeh Asgari; Ramezani, Amitis

doi:10.1016/j.micpath.2022.105618

Cited by 24 publications

(18 citation statements)

References 36 publications

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“…There has been a wide variety of SARS-CoV-2 studies conducted in the institute. More than 100 manuscripts are accessible in NCBI PubMed database (https://pubmed.ncbi.nlm.nih.gov/) in which Pasteur Institute has contributed to SARS-CoV-2 publications including basic, preclinical and clinical studies (22)(23)(24), COVID-19 mechanisms (25,26), diagnosis and therapeutic targets (27)(28)(29)(30)(31)(32), case reports (33,34), long COVID (35,36) reviews and metaanalysis (21,37), bioinformatics and In Silico studies (38-40).…”

Section: Resultsmentioning

confidence: 99%

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

Larijani

Biglari

Sorouri

et al. 2022

Preprint

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Background The present study aims to show the comprehensive effort of Pasteur Institute of Iran and its scientists regarding COVID-19 chaos management, related studies, achievements and vaccine production though there were many imposed challenges. Methods The relevant literature review was done through the associated data from national and international databases, published and under review research articles and also through reports obtained from official meetings with the heads of the related departments. Results The taken strategy adopted by Pasteur Institute of Iran was based on six arms including COVID-19 laboratory network establishment, vaccine research and production, monitoring of SARS-CoV-2 variants, diagnostic tests production, conduction of applied and basic research, and community management and support which eventually utilized appropriate technology for facilitating vaccination as well as the pandemic control at the right time. Conclusion The COVID-19 pandemic which was going to be a real crisis, led to a precise and great performance of Pasteur Institute of Iran owing to the unity of the scientists and the staff. COVID-19 pandemic has been managed by COVID-19 laboratory network set up, approved vaccines in collaboration with Cuba, evaluation and validation system of diagnostic and immunological COVID-19 kits, community Support and careful SARS-CoV-2 Variants Screening. COVID-19 is not over yet and the role of Pasteur Institute of Iran in dealing with this pandemic is still pivotal. There are some other challenges to overcome such as preparation for any COVID-19 probable trend, data management and update, long-term safety and efficacy of the vaccines and providing supplies.

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Section: Resultsmentioning

confidence: 99%

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

Larijani

Biglari

Sorouri

et al. 2022

Preprint

Self Cite

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“…There was a group of patients in this study, however, in whom it could not be determined whether residuals of the infection with SARS-CoV-2 caused the complaints or whether it aggravated an underlying disease. This group needs to be further investigated because, contrary to adult patients, there is no evidence as to which underlying diseases predispose children to develop LC [ 35 ]. In clinical practice, these patients do not fit into the standard health care system and therefore are in special need of a multi-professional team to rule out differential diagnoses, organize follow-up visits and supportive treatments such as physiotherapies [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Alternative Diagnoses in Children and Adolescents with Suspected Long COVID—A Single Center Cohort Study

Goretzki

Brasseler

Dogan

et al. 2023

Viruses

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Background: Long COVID (LC) is a diagnosis that requires exclusion of alternative somatic and mental diseases. The aim of this study was to examine the prevalence of differential diagnoses in suspected pediatric LC patients and assess whether adult LC symptom clusters are applicable to pediatric patients. Materials and Methods: Pediatric presentations at the Pediatric Infectious Diseases Department of the University Hospital Essen (Germany) were assessed retrospectively. The correlation of initial symptoms and final diagnoses (LC versus other diseases or unclarified) was assessed. The sensitivity, specificity, negative and positive predictive values of adult LC symptom clusters were calculated. Results: Of 110 patients, 32 (29%) suffered from LC, 52 (47%) were diagnosed with alternative somatic/mental diseases, and 26 (23%) remained unclarified. Combined neurological and respiratory clusters displayed a sensitivity of 0.97 (95% CI 0.91–1.00) and a negative predictive value of 0.97 (0.92–1.00) for LC. Discussion/Conclusions: The prevalence of alternative somatic and mental diseases in pediatric patients with suspected LC is high. The range of underlying diseases is wide, including chronic and potentially life-threatening conditions. Neurological and respiratory symptom clusters may help to identify patients that are unlikely to be suffering from LC.

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“…From another point of view, the quick procedure of vaccine development could possibly have lately unsolicited events beside the immunity protection. Many studies have shown SARS-CoV-2 manifestations through which the virus affect body in various presentations even in a late episode (7,8). As the number of vaccinated individuals grows up, the knowledge of possible and probable vaccine impact develops through case reports and long-term safety studies (9,10).…”

Section: Of 13mentioning

confidence: 99%

A Landscape on Disorders Following Different COVID-19 Vaccination: A Systematic Review of Iranian Case Reports

Larijani¹,

Doroud²,

Banifazl³

et al. 2023

Preprint

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Vaccination against SARS-CoV-2 has significantly contributed to the recent pandemic control. COVID-19 vaccines are available with different platforms and the primary clinical trials results presented acceptable safety profile of the approved vaccines. Nevertheless, the long-term assessment of the adverse events or rare conditions need to be investigated. The present systematic review, aimed at classification of Iranian case reports following COVID-19 immunization. To achieve this goal, the related published case reports were explored via PubMed, Web of Science and Google scholar according to PRISMA guideline and available up to 14th Dec, 2022. Out of 437 explored studies, the relevant data were fully investigated which totally led to 40 studies including 64 case reports with a new onset of a problem. The cases were then classified according to the various items such as the type of adverse event manifestations and COVID-19 vaccine. The reported COVID-19 vaccines in the studied cases included Sinopharm, AstraZeneca, and COVAXIN. The results showed that the adverse events presented in 8 different categories from which cutaneous problems accounted as the most prevalent manifestations (43.7%) in which rare diseases were also screened such as Steven-Johnson syndrome, Morphea and Toxic Epidermal Necrolysis. Notably, almost 60% of the cases had no comorbidities. Moreover, the obtained data revealed nearly half of the incidences occurred after the first dose of injection and the mean duration of improvement after the symptom onset was 18.72±24.69 days. 73% of all the cases were either significantly improved or fully recovered. Although the advantages of COVID-19 vaccination is undoubtedly significant, the high risk individuals including those with a history of serious disease or comorbidities immunodeficiency conditions should be vaccinated with the utmost caution.

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Characterization of long COVID-19 manifestations and its associated factors: A prospective cohort study from Iran

Cited by 24 publications

References 36 publications

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles

High Prevalence of Alternative Diagnoses in Children and Adolescents with Suspected Long COVID—A Single Center Cohort Study

A Landscape on Disorders Following Different COVID-19 Vaccination: A Systematic Review of Iranian Case Reports

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