Characterization of Lipid-Rich Aortic Plaques by Intravascular Photoacoustic Tomography

Abstract

In an animal model, IVPAT allowed characterization of spatial and quantitative features of lipid-rich plaques.

High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm

“…Using a laser with 10 Hz repetition rate, one cross-sectional image requires tens of seconds to finish, which limits the translation of the technology for in vivo application. 16,18,21,23,24 In this letter, we report on a two orders of magnitude faster integrated IVPA/IVUS hybrid imaging system with a 500 Hz nanosecond-pulsed optical parametric oscillator (OPO) laser at 1.7 lm. An IVPA catheter with 1.0 mm outer diameter (OD) was designed and tested by a lipid-mimicking phantom.…”

“…[13][14][15] Based on the optical absorption contrast of the tissues within the vessel wall, intravascular photoacoustic (IVPA) imaging for characterizing plaque compositions has been studied. [16][17][18][19][20][21][22][23][24][25][26][27] Recently, due to the high optical absorption by first overtone of C-H bonds around 1720 nm, IVPA imaging of lipid-rich atherosclerotic plaque at 1.7 lm spectral band has been attracting great attention. 21,28 However, current IVPA imaging speed is limited by the repetition rate of commercial nanosecond lasers at 1.7 lm.…”

High-Risk Stents Harboring Neoatherosclerosis

“…This lack of axial (depth) In summary, Madder et al 13 are to be congratulated for investigating the ability of NIRS-IVUS to shed light on the pathogenesis of neoatherosclerosis, an emerging indicator of high-risk stents at risk of stent thrombosis and restenosis. In addition to OCT, IVUS-virtual histology, angioscopy, and possibly NIRS-IVUS, novel imaging approaches such as intravascular photoacoustic tomography 14,15 and near-infrared fluorescence molecular imaging 16,17 might prove useful in detecting neoatherosclerosis. We have much to learn about this disease and how to prevent it-and intravascular imaging remains essential in this endeavor.…”

All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector

“…We can abstract the information of absorption and scattering to diagnose the pathology changes of the tissue. Typically, PA and OCT can simultaneously measure the size of lipid core and the thickness of thin fibrous cap in cardiovascular disease [8,27]. In addition, this alloptically noncontact dual-mode imaging system can be conveniently used to diagnose ophthalmology and dermatology disease due to its noncontact mode.…”