Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx

Lewin, Jan S.; Gillenwater, Ann M.; Garrett, J. V.; Bishop-Leone, Julie K.; Nguyen, Di; Callender, Marc; Ayers, Gregory D.; Myers, Jeffrey N.

doi:10.1002/cncr.11158

Cited by 72 publications

(47 citation statements)

References 11 publications

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“…This matches the common hypothesis of having proximal reflux events in patients with LPR occurring almost exclusively in the upright position [22,23,24,25]. In a recent study, Hoppo et al [22] proposed a mechanism to explain the theory of upright reflux in LPR patients.…”

Section: Discussionsupporting

confidence: 60%

Voice Problems among Laryngopharyngeal Reflux Patients Diagnosed with Oropharyngeal pH Monitoring

Mesallam

Malki²,

Farahat³

et al. 2013

Folia Phoniatr Logop

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Background and Objectives: There is a lack of consensus regarding the clinical presentation and diagnosis of laryngopharyngeal reflux (LPR). The aim of this study was to explore voice-related abnormalities in a group of LPR patients, diagnosed with a 24-hour oropharyngeal pH monitoring. Patients and Methods: Eighty-two patients with voice-related problems participated in the study. Diagnosis of LPR was made using a 24-hour oropharyngeal pH monitoring. Patients were divided accordingly into positive and negative pH groups. Comparisons between the two groups were done, including results of clinical presentation, Voice Handicap Index-10 (VHI-10), reflux symptom index (RSI), reflux finding score (RFS), and acoustic measurements. The correlation was conducted between Ryan scores and other variables including VHI-10, RSI, and RFS. Results: Significant differences were found between the two groups for RSI and VHI-10. No significant differences were found between the two groups regarding clinical presentation, RFS or acoustic measures. Significant positive correlations were found between the Ryan composite measurements and both severity ratings (VHI-10, RSI). Conclusion: LPR clinical presentation appears to be non-specific in terms of symptoms and laryngeal findings. LPR appears to have an effect on the patients' self-perception of voice problems. Further studies are needed to clarify the effect of LPR on acoustic measurements.

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Section: Discussionsupporting

confidence: 60%

Voice Problems among Laryngopharyngeal Reflux Patients Diagnosed with Oropharyngeal pH Monitoring

Mesallam

Malki²,

Farahat³

et al. 2013

Folia Phoniatr Logop

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“…These manifestations are known collectively as extraesophageal or atypical presentations of GERD. Such atypical symptoms include non-cardiac chest pain, asthma, chronic cough, bronchitis, aspiration pneumonia, idiopathic pulmonary fibrosis, globus, hoarseness, laryngitis, subglottic stenosis, vocal cord granuloma, and laryngeal cancer [7,8,9,10,11,12]. Since the prevalence of GERD in patients presenting with those atypical symptoms has not been high [13], it is of importance to document and clarify the relationship between GERD and atypical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Pepsin Detection in the Sputum/Saliva for the Diagnosis of Gastroesophageal Reflux Disease in Patients with Clinically Suspected Atypical Gastroesophageal Reflux Disease Symptoms

Kim¹,

Lee²,

Yeo³

et al. 2008

Digestion

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Background/Aims: Atypical manifestations of gastroesophageal reflux disease (GERD) are diverse. We aimed to determine whether pepsin detection in the sputum/saliva could be useful for diagnosing GERD in patients with clinically suspected atypical GERD symptoms. Methods: Patients with clinically suspected atypical GERD symptoms provided sputum/saliva collected before bedtime, at the time of those symptoms, and after awakening for pepsin measurement by Western blot analysis. All subjects received 24-hour esophageal pH monitoring, and then 40 mg of esomeprazole was given twice a day for 2 weeks. Results: The pepsin test was positive in 20 out of 40 patients, with pepsin detected mainly in the samples collected at the time of symptoms (45%). Samples collected from healthy volunteers (n = 8) were all negative for pepsin. 24-hour pH-metry was positive in 9 patients (23%). Based on 24-hour pH-metry data, the sensitivity and negative predictive value of the pepsin test were excellent in most of typical and atypical symptom groups, whereas its specificity and positive predictive value were relatively low, particularly in atypical symptom groups. Conclusions: Pepsin measurement in the sputum/saliva collected at the time of symptoms provides a sensitive, non-invasive method for diagnosing GERD in patients with clinically suspected atypical GERD symptoms.

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“…85% of the patients with malignant and premalignant lesions have positive results in the esophageal pH test, without being described a statistically significant association between the existence of LPR and the histological type 21 .…”

Section: Laryngeal Cancermentioning

confidence: 91%

The impact of gastroesophageal reflux in the ENT pathology

Melinte

Sarafoleanu

2016

Romanian Journal of Rhinology

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Frequently encountered in medical practice, the gastroesophageal reflux (GER) is a chronic condition characterized by the passage of gastric acid or gastric contents into the esophagus. In otorhinolaryngology, the diagnosis of pharyngo-laryngeal or rhinosinusal inflammatory conditions secondary to GER is one of exclusion and it is based on a detailed anamnesis in which we are interested in symptoms, behavioural and medical risk factors, on the ENT clinical examination, the laryngo-fibroscopical assessment, the phoniatric examination, the barite pharyngo-esogastric exam, the upper gastrointestinal endoscopy and the esophageal manometry. The authors are making a systematization of the contribution of the gastroesophageal reflux has in the ENT pathology, emphasising the sympytoms and the most frequent associated pathological entities.

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Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx

Cited by 72 publications

References 11 publications

Voice Problems among Laryngopharyngeal Reflux Patients Diagnosed with Oropharyngeal pH Monitoring

Voice Problems among Laryngopharyngeal Reflux Patients Diagnosed with Oropharyngeal pH Monitoring

Pepsin Detection in the Sputum/Saliva for the Diagnosis of Gastroesophageal Reflux Disease in Patients with Clinically Suspected Atypical Gastroesophageal Reflux Disease Symptoms

The impact of gastroesophageal reflux in the ENT pathology

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