Characterization of Large Granular Lymphocyte (Lgl) Tumors in the Rat

Reynolds, Craig W.; Ward, Jerrold M.; Denn, Alfred C.; Bere, Earl W.

doi:10.1016/b978-0-12-722380-3.50009-x

B and T Cell Tumors 1982

DOI: 10.1016/b978-0-12-722380-3.50009-x

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Characterization of Large Granular Lymphocyte (Lgl) Tumors in the Rat

Craig W. Reynolds

Jerrold M. Ward

Alfred C. Denn

et al.

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1983

1985

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Cited by 3 publications

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“…Similarly, the spontaneous lymphomas of aged Fischer rats have recently been shown to represent tumors of LGLs. with a considerable propor tion of them having high levels of NK activ ity [53]. Such tumors are already proving quite useful for isolation of the characteristic cytoplasmic granules of NK cells.…”

mentioning

confidence: 99%

Current Status and Perspective of Natural Killer Cell Research

Herberman¹

1983

Pathol Immunopathol Res

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mentioning

confidence: 99%

Current Status and Perspective of Natural Killer Cell Research

Herberman¹

1983

Pathol Immunopathol Res

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Large granular lymphocyte (LGL) lymphoproliferative diseases: Naturally cytotoxic tumors in man and experimental animals

Reynolds¹

1985

Critical Reviews in Oncology/Hematology

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T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics

Reynolds

Foon

1984

Blood

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T gamma lymphocytes are those lymphocytes that express receptors for both the Fc portion of IgG and sheep erythrocytes. A very high proportion of normal T gamma lymphocytes are large granular lymphocytes (LGL), the cell responsible for most, if not all, natural killer (NK) and antibody-dependent cell-mediated cytotoxicity (ADCC) in humans, rats, and mice. In general, these cells are large lymphocytes with prominent azurophilic granules in the cytoplasm. Recently, a group of lymphoproliferative disorders made up predominantly of T gamma lymphocytes has been described. The most common and best studied of these disorders we refer to as “chronic T gamma-lymphoproliferative disease” (T gamma-LPD). In most cases, this disease represents the abnormal expansion of LGL, which is reflected by an increase in functionally active NK or ADCC effector cells. The chronic T gamma-LPD lymphocytes are generally characterized as E- and EA-rosette positive, acid-phosphatase, and beta-glucuronidase positive and express the pan-T antigens OKT3/Leu-4, OKT11/Leu-5, the suppressor-associated antigens OKT5,8/Leu-2, and the NK-associated antigens Leu-7/HNK-1. Typically, the patients are older, predominantly males and characteristically have a lymphocytosis of predominantly T gamma lymphocytes with lymphocyte infiltration of the bone marrow and often the spleen. While chronic T gamma-LPD is not usually an aggressive disease, the patients are often neutropenic and have recurrent bacterial infections requiring antibiotic therapy. Some patients have benefited from cytotoxic chemotherapy., but most patients have not required chemotherapy. An experimental LGL leukemia in F344 rats appears morphologically, functionally, and clinically similar to the human chronic T gamma-LPD and serves as an experimental model for further examining the ontogeny and function of LGL and may be applicable for exploring new and more effective means for the treatment of patients with chronic T gamma-LPD.

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Characterization of Large Granular Lymphocyte (Lgl) Tumors in the Rat

Cited by 3 publications

References 8 publications

Current Status and Perspective of Natural Killer Cell Research

Current Status and Perspective of Natural Killer Cell Research

Large granular lymphocyte (LGL) lymphoproliferative diseases: Naturally cytotoxic tumors in man and experimental animals

T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics

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