Characterization of iron compounds in tumour tissue from temporal lobe epilepsy patients using low temperature magnetic methods

Brem, Franziska; Hirt, Ann M.; Simon, Christian; Wieser, Heinz‐Gregor; Dobson, Jon

doi:10.1007/s10534-004-6253-y

Cited by 15 publications

(21 citation statements)

References 30 publications

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“…This data does not correspond to the presence of O 2 , Cu(II), Cr(III), Fe(III)/Fe(II), ferritin or other paramagnetic species. Moreover, FCM/ZFCM measurements do not match the presence of ferritin because of absence the fingerprint feature (a maximum at the ZFCM curve) at ca 10 K [30]. In addition, FCM/ZFCM measurements show features at around 50 K that are characteristic for the presence of magnetite [31].…”

Section: Discussionmentioning

confidence: 94%

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Kopáni¹,

Hlinkova²,

Ehrlich³

et al. 2017

J Bioanal Biomed

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Postmortem brain tissue sections from Globus pallidus externus were routinely obtained during the autopsy to prepare tissue sections for the pathology diagnosis at Department of pathology, Comenius University, Bratislava. Tissues were taken from individuals without clinical findings of any motor abnormalities, iron metabolism, movements involving limbs, face, and tongues (Table 1). All procedures were conducted in accordance with the Declaration of Helsinki. AbstractSeveral types of iron oxides can be found in the various parts of the human brain. These can be highlighted in the light microscopy and using scanning or transmission mode of the electron microscopy. Some of them are non-magnetic, some, on the contrary, display magnetic response. It is not clear which kind of magnetic particles are accumulated in the human brain as inorganic deposits. Light microscopy, electron microscopy and sensitive Superconducting Quantum Interference Device (SQUID magnetometer) were used in order to detect iron deposits and their magnetic response in the samples extracted from the Globus pallidus of the human brain. Electron microscopy reveals a presence of the single crystals of hematite (α-Fe 2 O 3 ) of the size up to 1000 nm in the samples extracted from G. pallidus because of the diffractograms characteristic for the hexagonal unit cell; this mineral offers basically a diamagnetic response. The temperature dependence of the magnetic susceptibility allows a classification of the samples into three groups: mostly diamagnetic I, prevailing paramagnetic III, and an intermediate class II. The bulk samples exhibit a long-range magnetic ordering with magnetic hysteresis evidenced not only at low temperature but also at the room temperature. The recorded magnetic functions refer either to the presence of magnetite (Fe 3 O 4 ), or maghemite (γ-Fe 2 O 3 ). Iron oxides and oxidohydroxides found as inorganic deposits in the human brain can result from interaction between iron and microenvironment in the form of polysaccharides of glycoconjugates. They display magnetoactivity characteristic for magnetite and/or maghemite.

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Section: Discussionmentioning

confidence: 94%

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Kopáni¹,

Hlinkova²,

Ehrlich³

et al. 2017

J Bioanal Biomed

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“…For example, ferritin-derived ferrihydrite in humans, with varying degrees of structural order, has been related to different neurodegenerative diseases (26). In this regard, biogenic ferrimagnetic crystals, identified as magnetite, that have been found in human brain tissues (27)(28)(29) may originate from biodegradation of a ferrihydrite precursor.…”

mentioning

confidence: 99%

Ordered ferrimagnetic form of ferrihydrite reveals links among structure, composition, and magnetism

Michel

Barrón

Torrent

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

340

393

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The natural nanomineral ferrihydrite is an important component of many environmental and soil systems and has been implicated as the inorganic core of ferritin in biological systems. Knowledge of its basic structure, composition, and extent of structural disorder is essential for understanding its reactivity, stability, and magnetic behavior, as well as changes in these properties during aging. Here we investigate compositional, structural, and magnetic changes that occur upon aging of "2-line" ferrihydrite in the presence of adsorbed citrate at elevated temperature. Whereas aging under these conditions ultimately results in the formation of hematite, analysis of the atomic pair distribution function and complementary physicochemical and magnetic data indicate formation of an intermediate ferrihydrite phase of larger particle size with few defects, more structural relaxation and electron spin ordering, and pronounced ferrimagnetism relative to its disordered ferrihydrite precursor. Our results represent an important conceptual advance in understanding the nature of structural disorder in ferrihydrite and its relation to the magnetic structure and also serve to validate a controversial, recently proposed structural model for this phase. In addition, the pathway we identify for forming ferrimagnetic ferrihydrite potentially explains the magnetic enhancement that typically precedes formation of hematite in aerobic soil and weathering environments. Such magnetic enhancement has been attributed to the formation of poorly understood, nano-sized ferrimagnets from a ferrihydrite precursor. Whereas elevated temperatures drive the transformation on timescales feasible for laboratory studies, our results also suggest that ferrimagnetic ferrihydrite could form naturally at ambient temperature given sufficient time.crystal structure | disorder | nano-sized ferrimagnets | soil formation | strain T he structural and physical properties of ferrihydrite, an exclusively nano-sized ferric oxyhydroxide, are of importance in explaining its chemical reactivity and wide variety of occurrences. In both pristine and contaminated soils and sediments, ferrihydrite acts as a natural filter of inorganic contaminants through sorption reactions, thus affecting their transport and fate in the environment. Biomineralization of ferrihydrite as the inorganic iron core in ferritin-the protein mainly involved in iron storage and homeostasis in the human body-also occurs in a vast number of organisms (1). Bloom-forming marine diatoms, for example, use ferritin for enhanced iron storage (2), which suggests that ferrihydrite may also have underlying importance in primary productivity in the world's oceans.A well-known example of a nanomineral (3), ferrihydrite has no known crystalline counterpart formed in the laboratory or found in nature. As such, the basic crystal structure (4-7) and physical properties of ferrihydrite [e.g., density, composition (7, 8), and magnetic properties (9-14)] have remained controversial. A variety of structural models ha...

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“…That is why historically the idea of magnetotaxis was transformed into an 59 dolphins, whales, 60 and humans. 8,16,17,22,[61][62][63][64][65][66][67] Table 1 provides general information on BMNPs in different organisms.…”

Section: Physicochemical Properties Of Bmnps Bmnps In Mtb Magnetosomesmentioning

confidence: 99%

“…The problem of the physiological origin of BMNPs gains in importance in light of the discovery of BMNPs in a number of human organs and tissues 61,91 and their observed relation to neurodegenerative disorders, 16,17,19,67 cancer (Figure 3), 20,21 and atherosclerosis ( Figure 4). 92 Concentrations of BMNPs in inflammation zones in neurodegenerative diseases [93][94][95][96][97] and cancer 8,20 are higher than those observed in normal tissues.…”

Section: Bmnps In Human Diseasementioning

confidence: 99%

“…The problem is very important, since elevated BMNP levels are associated with a number of human diseases, including neurodegenerative disorders and cancer. [16][17][18][19][20][21] Until recently, there had been only one hypothesis: that ferrihydrite present in the ferritin core might be a precursor of biogenic magnetite. Indeed, ferrihydrite has been proved experimentally to be a transient mineral in the formation of magnetite in cells of MTB 22 and in chiton teeth.…”

Section: Introductionmentioning

confidence: 99%

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Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

Gorobets¹,

Gorobets²,

Koralewski³

2017

IJN

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The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels in health and disease (cancer, neurodegenerative disorders, and atherosclerosis), and discuss the existing hypotheses on the biological functions of BMNPs, with special attention paid to the role of the ferritin core and apoferritin.

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Characterization of iron compounds in tumour tissue from temporal lobe epilepsy patients using low temperature magnetic methods

Cited by 15 publications

References 30 publications

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Ordered ferrimagnetic form of ferrihydrite reveals links among structure, composition, and magnetism

Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

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