Characterization of ion channels on subesophageal ganglion neurons from Chinese tarantula Ornithoctonus huwena: Exploring the myth of the spider insensitive to its venom

Deng, Mei; Hu, Zhaotun; Cai, Tianfu; Li, Kai; Wu, Wei; Luo, Xuan; Jiang, Liping; Wang, Meichi; Yang, Jing; Xiao, Yucheng; Liang, Songping

doi:10.1016/j.toxicon.2016.07.011

Cited by 3 publications

(3 citation statements)

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“…Nevertheless, given that a number of toxic animal species are known to feed cannibalistically at least part of the time (Burchfield, 1977;Polis and Myers, 1985;Pizzatto and Shine, 2008), autoresistance can also be linked to predation or defence directly in some cases. Indeed, in species where cannibalism is common it is plausible that the maintenance of autoresistance could be partly driven by such interactions, as suggested for the insensitivity of tarantula ion-channels towards tarantula toxins (Deng et al, 2016).…”

Section: Toxin Resistance Is Widespread Across the Animal Tree Of Lifementioning

confidence: 99%

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

Arbuckle

Vega

Casewell

2017

Toxicon

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Understanding how biotic interactions shape the genomes of the interacting species is a long-sought goal of evolutionary biology that has been hampered by the scarcity of tractable systems in which specific genomic features can be linked to complex phenotypes involved in interspecific interactions. In this review we present the compelling case of evolved resistance to the toxic challenge of venomous or poisonous animals as one such system. Animal venoms and poisons can be comprised of few or of many individual toxins. Here we show that resistance to animal toxins has evolved multiple times across metazoans, although it has been documented more often in phyla that feed on chemically-armed animals than in prey of venomous predators. We review three types of gene-product based resistance: 1) toxin scavenging, where molecules produced by the envenomed organism bind and inactivate the toxins; 2) target-site insensitivity, including landmark cases of convergent changes that make the molecules normally targeted by animal toxins refractory, and; 3) off-target repurposing, where envenomed organisms overcome toxicity by exploiting the function of toxins to alter their physiological effect. We finish by discussing the evolutionary processes that likely played a role in the origin and maintenance of toxin resistance. We conclude that antagonistic interactions involving poisonous or venomous animals are unparalleled models for investigating microevolutionary processes involved in coevolution and linking them to macroevolutionary patterns.

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Section: Toxin Resistance Is Widespread Across the Animal Tree Of Lifementioning

confidence: 99%

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

Arbuckle

Vega

Casewell

2017

Toxicon

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“…ABH12275; Figure 3 ). This indicates that the substitutions of the acidic amino acids in the critical region with neutral amino acids may cause the self-resistance to their own toxin [ 216 , 217 ]. Jingzhaotoxin-I is a 33 amino acid residue inhibitor cysteine knot motif peptide that has been separated from tarantula, Chilobrachys jingzhao , venom.…”

Section: Toxins From Terrestrial Animalsmentioning

confidence: 99%

Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms

Ogawara

2018

Molecules

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Drug resistance, especially antibiotic resistance, is a growing threat to human health. To overcome this problem, it is significant to know precisely the mechanisms of drug resistance and/or self-resistance in various kingdoms, from bacteria through plants to animals, once more. This review compares the molecular mechanisms of the resistance against phycotoxins, toxins from marine and terrestrial animals, plants and fungi, and antibiotics. The results reveal that each kingdom possesses the characteristic features. The main mechanisms in each kingdom are transporters/efflux pumps in phycotoxins, mutation and modification of targets and sequestration in marine and terrestrial animal toxins, ABC transporters and sequestration in plant toxins, transporters in fungal toxins, and various or mixed mechanisms in antibiotics. Antibiotic producers in particular make tremendous efforts for avoiding suicide, and are more flexible and adaptable to the changes of environments. With these features in mind, potential alternative strategies to overcome these resistance problems are discussed. This paper will provide clues for solving the issues of drug resistance.

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“…Spiders are one of the oldest and most abundant venomous animals, with a fossil history spanning more than 300 million years and over 40,000 species (Deng et al, 2016). Every year, approximately 10,000 spider bites are reported in Brazil and nearly 3,000 bites in America (Braitberg & Segal, 2009).…”

Section: Introductionmentioning

confidence: 99%

Haplopelma hainanum venom induces inflammatory skin lesions

Deng

Wang

Shi

et al. 2020

PeerJ

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The Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The pathological consequences of envenomation by H. hainanum remain unclear. In this study, we investigated the effects and mechanisms of H. hainanum envenomation in mice. We showed that the venom induced slight swelling, intense inflammatory response, and increased the microvascular density in mice skin. Moreover, we found that 50 µg/ml of the spider’s venom induced IL-1β expression in both HaCaT cells and fibroblast cells, but repressed CXCL10 expression in fibroblasts. The venom significantly induced cell senescence and repressed cell proliferation and migration in both HaCaT cells and fibroblast cells. Finally, we examined the expression of Nav channel in HaCaT and fibroblast cells and found that H. hainanum venom effectively inhibited Na+ currents in HaCaT cells. Our study calls for further investigation of the pathological consequences and potential mechanisms of H. hainanum envenomation. This information might assist in the development of suitable therapy.

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Characterization of ion channels on subesophageal ganglion neurons from Chinese tarantula Ornithoctonus huwena: Exploring the myth of the spider insensitive to its venom

Cited by 3 publications

References 28 publications

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals

Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms

Haplopelma hainanum venom induces inflammatory skin lesions

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