Characterization of invasive Neisseria meningit idis strains isolated at the Children's Hospital of Tunis, Tunisia

Saguer, Awatef; Smaoui, H.; Taha, Muhamed‐Kheir; Kechrid, A.

doi:10.26719/2016.22.5.343

Cited by 11 publications

(23 citation statements)

References 20 publications

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“…Our data showed that the majority of the isolates were of serogroup B, in agreement with a previous report (13). Recent data from Tunisia also suggested that serogroup B predominated in the country between 1998 and 2013 (23). Serogroup B isolates were also reported in Algeria between 1992 and 2001 (24).…”

Section: Discussionsupporting

confidence: 92%

Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco

et al. 2018

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Meningococcal epidemiology may change unpredictably, and typing of isolates is crucial for the surveillance of invasive meningococcal disease (IMD). Few data are available regarding the meningococcal epidemiology in countries of North Africa. We aimed to explore invasive meningococcal isolates from the Casablanca region in Morocco. We used whole-genome sequencing (WGS) to characterize 105 isolates from this region during the period of 2011 to 2016. Our data showed that the majority ( = 100) of the isolates belonged to serogroup B. Genotyping indicated that most of the isolates ( = 62) belonged to sequence type 33 of clonal complex 32. The isolates also showed the same PorA and FetA markers and clustered together on the basis of WGS phylogenetic analysis; they seemed to correspond to an expansion of local isolates in the Casablanca region, as reported for similar isolates in several other countries. These data suggest that serogroup B isolates may predominate in Morocco, which may have an important impact in the design of vaccination strategies.

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Section: Discussionsupporting

confidence: 92%

Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco

et al. 2018

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“…Surveillance data indicated that the incidence and prevalence of Nm serogroups continually varies both geographically and temporally [23,24]. Currently, meningococcal serogroup B (MenB) is a major cause of IMD in North America, South America, Australia, North Africa, and Europe, although a decreasing incidence trend is being observed [25], which was supported by the data presented from other countries at the 2018 GMI meeting [10,11,[26][27][28][29][30]. The incidence and prevalence of MenB naturally fluctuates over time and is currently at an all-time low; the reasons for this were unknown, but it was hypothesized that the introduction of a smoking ban in public places in some countries may have played a role.…”

Section: Serogroup Distributionmentioning

confidence: 83%

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Acevedo

Bai

Borrow

et al. 2018

Expert Review of Vaccines

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2019) The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and highrisk populations, Expert Review of Vaccines, 18:1, 15-30, ABSTRACT Introduction: The 2018 Global Meningococcal Initiative (GMI) meeting focused on evolving invasive meningococcal disease (IMD) epidemiology, surveillance, and protection strategies worldwide, with emphasis on emerging antibiotic resistance and protection of high-risk populations. The GMI is comprised of a multidisciplinary group of scientists and clinicians representing institutions from several continents. Areas covered: Given that the incidence and prevalence of IMD continually varies both geographically and temporally, and surveillance systems differ worldwide, the true burden of IMD remains unknown. Genomic alterations may increase the epidemic potential of meningococcal strains. Vaccination and (to a lesser extent) antimicrobial prophylaxis are the mainstays of IMD prevention. Experiences from across the globe advocate the use of conjugate vaccines, with promising evidence growing for protein vaccines. Multivalent vaccines can broaden protection against IMD. Application of protection strategies to high-risk groups, including individuals with asplenia, complement deficiencies and human immunodeficiency virus, laboratory workers, persons receiving eculizumab, and men who have sex with men, as well as attendees at mass gatherings, may prevent outbreaks. There was, however, evidence that reduced susceptibility to antibiotics was increasing worldwide. Expert commentary: The current GMI global recommendations were reinforced, with several other global initiatives underway to support IMD protection and prevention. ARTICLE HISTORY

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“…Finally, we note the presence of three cases of serogroup Y with a first appearance in 2013 in the Casablanca region [17]. In the Maghreb region, Meningococcal serogroup B represents 80.4 % of cases in Tunisia [18], moreover, in Algeria it represents 46.7 % of cases between 2003 and 2013 [19]. Serogroup B predominates in Europe, North America and Australia [3].…”

Section: Discussionmentioning

confidence: 98%

“…Thus at the national level, 10 % of the isolates are of serogroup C [24]. This figure remains much lower than that of Tunisia where serogroup C represents 12.2 % [18], 8 % in Algeria [19], 26 % in France [21], 50 % in Portugal [22] and 61 % in Switzerland [31].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010–2019

Mouss

Razki

Hong

et al. 2020

Access Microbiology

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Surveillance of invasive meningococcal diseases (IMD) must be carried out regularly and continuously in order to detect the emergence of strains of reduced susceptibility to antibiotics for therapeutic and prophylactic use and the appearance of new invasive clones. Molecular-typing approaches allow reliable traceability and powerful epidemiological analysis. This is an epidemiological study of Neisseria meningitidis causing meningitis in Casablanca, Morocco. The grouping was confirmed by PCR mainly on the isolates from cerebrospinal fluid (CSF). A total of 245 confirmed isolates of N .meningitidis were obtained between 2010 and 2019 of which 93 % are of group B. Overall, 24 % of all the isolates have a reduced susceptibility to penicillin G, but no resistance to penicillin G has been reported. All the isolated strains are susceptible to third-generation cephalosporins (3GCs). Genotyping by multilocus sequence typing (MLST) of a selection of 18 strains showed that the majority of isolates belong to the invasive clonal complex CC 32(9/18) followed by the CC 41/44(3/18).

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Characterization of invasive Neisseria meningit idis strains isolated at the Children's Hospital of Tunis, Tunisia

Cited by 11 publications

References 20 publications

Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco

Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010–2019

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