Characterization of Intor:Swiss Albino Mice Adopted in the Institute of Virology, Vaccines and Sera – Torlak, Belgrade in the Early Twentieth Century

Živković, Irena; Rajnpreht, Irena; Minić, Rajna; Mitić, Katarina; Aleksić, Iva; Kadrić, Jasminka; Petrušić, Vladimir

doi:10.1515/acve-2016-0025

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Primary hippocampal cell cultures were isolated from newborn (P0) Intor:Swiss mice pups [ 120 ]. Once the whole brain was isolated, cerebral hemispheres were peeled back and the meninges surrounding the hippocampi were removed.…”

Section: Methodsmentioning

confidence: 99%

Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Kapadia

Bijelić

Zhao

et al. 2017

acta neuropathol commun

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Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is often accompanied by brain atrophy and diverse neuropsychiatric manifestations of unknown origin. More recently, it was observed that cerebrospinal fluid (CSF) from patients and lupus-prone mice can be neurotoxic and that acute administration of specific brain-reactive autoantibodies (BRAs) can induce deficits in isolated behavioral tasks. Given the chronic and complex nature of CNS SLE, the current study examines broad behavioral performance and neuronal Ca2+ signaling in mice receiving a sustained infusion of cerebrospinal fluid (CSF) from CNS SLE patients and putative BRAs (anti-NR2A, anti-ribosomal P, and anti-α-tubulin). A 2-week intracerebroventricular (i.c.v.) infusion of CSF altered home-cage behavior and induced olfactory dysfunction, excessive immobility in the forced swim test, and perseveration in a learning task. Conversely, sustained administration of purified BRAs produced relatively mild, both inhibitory and stimulatory effects on olfaction, spatial learning/memory, and home-cage behavior. In vitro studies revealed that administration of some CSF samples induces a rapid influx of extracellular Ca2+ into murine neurons, an effect that could be partially mimicked with the commercial anti-NR2A antibody and blocked with selective N-methyl-D-aspartate (NMDA) receptor antagonists. The current findings confirm that the CSF from CNS SLE patients can be neuroactive and support the hypothesis that intrathecal BRAs induce synergistically diverse effects on all domains of behavior. In addition, anti-NMDA receptor antibodies may alter Ca2+ homeostasis of central neurons, thus accounting for excitotoxicity and contributing to the heterogeneity of psychiatric manifestations in CNS SLE and other autoantibody-related brain disorders.Electronic supplementary materialThe online version of this article (10.1186/s40478-017-0473-1) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Kapadia

Bijelić

Zhao

et al. 2017

acta neuropathol commun

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“…For potency test, we used outbred Intor:Swiss albino mice of both sexes [19]. Animals were kept in the vivarium, housed in polycarbonate cages, fi ve mice per cage, at a constant room temperature of 22±1 °C with a 12-h light/dark cycle (light on from 7:00 AM till 7:00 PM).…”

Section: Micementioning

confidence: 99%

Application of the 3R Concept in the Production of European Antiviperinum on Horses – Multisite, Low Volumes Immunization Protocol and Elisa

et al. 2018

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During time, both professionals and general public became aware of the importance of animal welfare. This term not only covers endangered wild animal species, animals used in food industry, pets and experimental animals, but also animals used in production of biologics. The implementation of the 3R concept (Replacement, Reduction and Refinement) is especially important in this type of production. In this article, we describe for the first time the low dose, low volume and multi-site immunization protocol, as well as appropriate ELISA we developed for production of European anti-viper (V. ammodytes, long horned) antivenom in horses, which can help to significantly improve the welfare of the used animals.

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“…The house mouse, identified as Mus musculus Linnaeus, 1758, has been a member of humanity's close circle throughout the centuries. Swiss Albino and BALB/c mice are a series of common subspecies formed by breeding and rearing house mice in the laboratory environment, and they are also small albino mammal species from the order Rodentia that are widely used in scientific studies (Van Loo et al, 2000;Živković et al, 2016;Ayırtır Başdinç, 2023).…”

Section: Introductionmentioning

confidence: 99%

Comparative Investigation of Tongue and Esophagus Morphometry in Swiss Albino and Balb-c Mice

Yılmaz,

Ayırtır Başdinç,

Karadağ

2024

Turkish JAF Sci.Tech.

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This study was carried out to obtain morphometric measurement values of tongue and esophagus in Swiss Albino and Balb-c mice, to examine the biometric differences of these measurements between sexes and groups. Thirty-two mice, 16 Swiss Albino (8 males, 8 females) and 16 Balb-c (8 males, 8 females), were used for this study. Mice anesthetized with the ketamine-xylazine combination were fixed by the technique. The tongue and esophagus of the mice were carefully dissected and removed. Then, morphometric measurements of the dissected organs were taken, and statistical analysis was performed. When the morphometric measurement values were examined, it was seen that all of the measurement values obtained from both Swiss Albino and Balb-c mice were higher in males than in females. Statistically significant differences were observed between the groups in all morphometric measurement values of tongue and esophagus in both mouse races (p<0.05). Additionally, positive and significant correlations were found between morphometric measurement values of tongue and esophagus in both groups according to gender. Differences in morphometric measurement values of the tongue and esophagus were determined between genders and groups in Swiss Albino and Balb-c mice. Furthermore, this study provided basic morphometric data that will benefit various scientific fields related to the tongue and esophagus in these animals, especially anatomical studies.

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Characterization of Intor:Swiss Albino Mice Adopted in the Institute of Virology, Vaccines and Sera – Torlak, Belgrade in the Early Twentieth Century

Cited by 3 publications

References 14 publications

Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Application of the 3R Concept in the Production of European Antiviperinum on Horses – Multisite, Low Volumes Immunization Protocol and Elisa

Comparative Investigation of Tongue and Esophagus Morphometry in Swiss Albino and Balb-c Mice

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