Characterization of inhibitory activity of camel urine on human platelet function

Alyahya, Asma Mohammed; Gader, Abdel Galil M. Abdel; Alhaider, Abdulqader A.

doi:10.1016/j.jtumed.2015.10.005

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…5 Anti-microbial properties of camel urine have been demonstrated in vitro showing antifungal activity on Candida albicans and Aspergillus nige and anti-bacterial activity against multi-drug resistant pathogenic bacteria [ 90 , 91 ]. Alyahya et al [ 92 ] showed in vitro anti-coagulant activity of camel urine, which significantly inhibits human platelet aggregation responses. In vitro studies have highlighted the potential of camel urine to inhibit the growth of tumours by limiting tumour angiogenesis and by their cytotoxicity against various human cancer cell lines.…”

Section: Resultsmentioning

confidence: 99%

Zootherapeutic uses of animals excreta: the case of elephant dung and urine use in Sayaboury province, Laos

Dubost

Kongchack

Deharo

et al. 2021

J Ethnobiology Ethnomedicine

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Background Despite a widespread aversion towards faeces and urine, animal excreta are used in traditional medicine in many countries since centuries, but records are scattered and few therapeutic uses have been accurately documented while in the current context of emerging zoonoses such records may be of major interest. Methodology In this study, we investigated the therapeutic uses that mahouts in Xayaboury province, Lao PDR make of elephant urine and faeces as well as of the brood chamber that beetles (Heliocopris dominus) fashion from elephant dung. Semi-structured interviews were conducted with mahouts on elephant diet, health problems and responses to disease, andwhether they use elephant products. Data were supplemented by interviews with traditional healers. Results Seven respondents reported the use of elephant urine in ethnoveterinary care for elephants and in human medicine in case of diabetes and otitis. 25 respondents reported therapeutic use of elephant faeces (EF) and elephant dung beetle brood chambers. The major indications are gastrointestinal and skin problems. Macerations or decoctions are drunk or used externally as a lotion. The mahouts attribute the therapeutic effectiveness of EFs to their content which includes the remains of many species from the elephant diet which they consider to be medicinal. Discussion The indications of these uses are consistent with pharmacological and clinical studies highlighting the properties of different animals’ urine and faeces and their curative potential tested in vivo. The acknowledgement by the mahouts of medicinal properties of elephant faecal bolus contrasts with the rare justifications of animal material use recorded in zootherapeutic studies, which falls within the symbolic domain. However, numerous studies highlight the preponderant role of the microbiota in physiological processes, raising the hypothesis of a curative action of EF, by rebalancing the user’s microbiota. Conclusion The therapeutic uses of EF preparations despite their possible curative properties are a potential source of zoonotic transmission from elephants to humans. In the current context of globalisation of trade which favours the emergence of zoonoses and in relation with the issue of One Health, it becomes crucial to further document the zootherapeutic practices to prevent emerging diseases. As elephants and local related ethnoethological knowledge are threatened, documenting them is urgent to contribute to their preservation.

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Section: Resultsmentioning

confidence: 99%

Zootherapeutic uses of animals excreta: the case of elephant dung and urine use in Sayaboury province, Laos

Dubost

Kongchack

Deharo

et al. 2021

J Ethnobiology Ethnomedicine

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“…Urotherapy is an alternative medicine, is a common practice in many countries, and is particularly significant in countries like India and China where alternative medicine is widely practiced (Alhaidar et al, 2011, Al-Abdalall, 2010. Currently, urine-therapy can be used as an unconventional medical practice on the basis of trial and error, and requires significant research to support its use in conventional medicine (Alyahya et al, 2016).…”

Section: Globalize Your Researchmentioning

confidence: 99%

Peculiar Therapeutic Property of Camel’s (Camelus dromedarius) Urine Against Multidrug Resistant Bacteria

Bhardwaj¹

2022

CRCT

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The remedial use of camel urine has been known for centuries, with evidence of its use for curative purposes found in early folklore. It has been used to cure different diseases; however, the significant therapeutic benefits of urine have yet to undergo rigorous scientific evaluation. The exploration of the use of camel urine is of great interest to determine their efficacy in pharmaceutical industry. This study investigated the effect of camel’s urine against five human pathogenic bacteria, to determine their efficacy against multidrug resistant microbes. The probe was done by agar well diffusion method. Multidrug resistant (MDR) strains of Bacillus subtilis (ATCC 6633), E. coli (ATCC 8739), Salmonella enterica (ATCC 14028), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 27853) were used in the study. Ciprofloxacin was used as standard. Maximum zone of inhibition was observed with Salmonella enterica which is 33 ± 0.2 mm. Additionally, Multidrug resistant (MDR) strains of E. coli, Pseudomonas aeruginosa and Staphylococcus aureus was strongly inhibited by camel’s urine. Moreover, MDR strains of Bacillus subtilis, also shows inhibition. The potency shown by camel’s urine for therapeutic action, recommends their use against multidrug resistant microorganisms. In this research work, scientific evidence has been presented that supports, therapeutic capabilities of camel’s urine which exhibited a potential antibacterial activity against the tested microorganisms and could be a potential source of new antimicrobial agents.

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“…Camel platelets show repressed platelet aggregation reactions to simple aggregation agents, and the platelet function analyser (PFA-100) closure times are drawn out. Both camel plasma and urine show repression reactions on human platelets; in particular, lactating camel urine exhibits a strong repression reaction on human platelet aggregation (Alyahya et al, 2016). It has been observed that the strong platelet blocking characteristics of camel urine are quite like the reactions of commonly used antiplatelet drugs, such as clopidogrel and aspirin (Alhaidar et al, 2011).…”

Section: Cardiovascular Activitymentioning

confidence: 99%

“…Cases of qualified physicians advising and co-prescribing urotherapy have been reported; however, no studies have established scientific evidence to support this type of therapy (Van Der Kroon, 1996). Currently, urine-therapy can only be used as an unconventional or complementary medical practice on the basis of trial and error, and requires significant research to support its use in conventional medicine (Alyahya et al, 2016). Many diseases, such as abdominal tumours, tuberculosis, haemorrhoids, leprosy, dropsy, abdominal enlargement, flatulence, colic and anaemia, have been treated with the urine of animals, including goats, sheep, buffalo, elephants, horses, camels and donkeys (Al-Abdalall, 2010).…”

Section: Introduction Urotherapy Conceptmentioning

confidence: 99%

A Review of the Therapeutic Characteristics of Camel Urine

Alkhamees¹,

Alsanad²

2017

Afr J Tradit Complement Altern Med

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Background: The therapeutic use of camel urine has been known for centuries, with evidence of its use for medicinal purposes found in early folklore. It has been used to cure different diseases; however, the significant therapeutic benefits of urine have yet to undergo rigorous scientific evaluation. In this review, a summary of the scientific evidence that supports these therapeutic actions has been presented. Materials and methods: A literature search of different electronic databases including PubMed, Medline, SCOPUS, Web of Knowledge, and Google Scholar were conducted to identify published studies exploring the therapeutic effects of camel urine. 'Camel' and 'Urine', 'Medicinal properties', 'Natural products' were entered into the databases as key words. Reference lists of published reviews retrieved by the search were also searched to identify relevant papers. Result: There have been several laboratory and limited clinical studies providing evidence of the therapeutic effects of camel urine in the treatment of cancer, viral hepatitis and other viral, bacterial and parasitic infections. Therapeutic uses in the cardiovascular system have also been discovered, with regard to platelet and fibrinolytic actions. Conclusion:The exploration of the use of camel urine is of great interest to determine the efficacy of this practice, as well as the safety of the patients being treated. This review presented the benefits of camel urine, which were commonly drawn from small laboratory studies. Therefore, many more preclinical and clinical studies are needed to examine the efficacy and safety of the use of camel urine in in the treatment of disease.

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Characterization of inhibitory activity of camel urine on human platelet function

Cited by 9 publications

References 21 publications

Zootherapeutic uses of animals excreta: the case of elephant dung and urine use in Sayaboury province, Laos

Zootherapeutic uses of animals excreta: the case of elephant dung and urine use in Sayaboury province, Laos

Peculiar Therapeutic Property of Camel’s (Camelus dromedarius) Urine Against Multidrug Resistant Bacteria

A Review of the Therapeutic Characteristics of Camel Urine

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