Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis

Ishii, Hidetoki; Tanaka, Hironori; Katoh, K.; Nakamura, Hitomi; Nagashima, Masakazu; Yoshino, S

doi:10.1053/joca.2001.0509

Cited by 121 publications

(117 citation statements)

References 12 publications

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“…However, we found insignificant difference in IL-6, INF-gamma in LLLT group compared to Lev group. Supporting our results, a previous study reported the involvement IFN-γ in the course of inflammation and cartilage damage in OA [21]. Another study by Nasonova et al showed that anti-INF gamma was superior to anti-TNF-alpha in treatment of rheumatoid arthritis [22], [23].…”

Section: Effects Of Ultrasound Versus Low Level Laser Therapy In Levosupporting

confidence: 90%

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Mahmoud¹,

Elbedewey²,

Abdelkader³

et al. 2017

IOSR JDMS

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Abstract:Objectives. Osteoarthritis (OA) Methods. Eighteen male rats divided into three groups; (Lev) group treated with levofloxacin (Lev), (US) group treated with Lev plus US and (LLLT) group treated with Lev plus low level laser therapy. All animals received total of 200 mg injection of Lev. Total of ten sessions of US and laser applied. Results. We found significant decrease of serum IL-1beta, Mankin's score and increase in knee extension angle in both US and LLLT groups compared to Lev group. US significantly lower IL-6, INF-gamma, CRP and significantly elevate IL-10 in US group compared to Lev and LLLT groups.Conclusion. Based on our finding, US may provide better therapeutic effect compared to LLLT in knee osteoarthritis as indicated by reduction of inflammatory cytokines, elevation of anti-inflammatory cytokines and better histopathological score.

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Section: Effects Of Ultrasound Versus Low Level Laser Therapy In Levosupporting

confidence: 90%

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Mahmoud¹,

Elbedewey²,

Abdelkader³

et al. 2017

IOSR JDMS

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“…Here we present the evidence, that only classically activated or M 1 macrophages are able to produce YKL-39 and that in response to IFN-γ and LPS stimulation undifferentiated monocytes were able to produce YKL-39. It has been shown that Th1 cells predominate in the synovium of patients with OA [38]. Consequently, IFN-γ which is one of the prevailing cytokine in OA tissues is able to induce the production of YKL-39 by monocyte-derived macrophages.…”

Section: Discussionmentioning

confidence: 99%

Comparison of YKL-39 and CHIT-1 expression during macrophages differentiation and polarization

Rosa¹,

Tibullo²,

Malaguarnera³

et al. 2013

MRI

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The chitinase-like proteins YKL-39 (chitinase 3-like-2) and Chitortriosidase (CHIT-1) are members of the chitinases family. YKL-39 expression has been associated with osteoarthritis, whereas CHIT-1 activity is regarded as a biochemical marker of macrophage activation. So far, the physiological or pathological role of YKL-39 in the inflammation is still poorly understood. We compared YKL-39 and CHIT-1 modulation during monocyte to macrophage transition and polarization. Gene expression analysis was investigated by real-time PCR from mRNA of human monocytes obtained from buffy coat of healthy volunteers, from mRNA of polarized macrophages to classically activated macrophages (or M 1 ), obtained by interferon-γ and lipopolysaccharide exposure, and from mRNA of alternatively activated macrophages (or M 2 ) obtained by interleukin-4 exposure. We demonstrated different variations of YKL-39 and CHIT-1 production during macrophages polarization. CHIT-1 levels gradually increase in the course of the time with a peak of expression between the fifth and the seventh day of culture. In contrast, YKL-39 expression was unaltered in the diverse stage of HMMs differentiation, but increased significantly in M 1 polarized macrophages and reverted to base levels in M 2 polarized macrophages. These findings indicated that the function of YKL-39 is much more restricted and selective than that exerted by CHIT-1.

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“…IFN-g was detected by means of immunohistochemistry (IHC) 26,57,63 . The cellular origin of IFN-g remains unclear.…”

Section: Cytokines Detected In Oa Stmentioning

confidence: 99%

“…Neutrophils were almost never found 21,34,35,44,48,62 . Overall OA ST contained fewer number of inflammatory cells than RA ST 25,30,36,37,44,45,56,57,63,65,68,69,71,75,78 , but more than normal control ST 25,34,44,45,50,51,55,57,59,61e63,65,67,70,71,75,78 .…”

mentioning

confidence: 92%

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

Lange-Brokaar

Ioan‐Facsinay

Osch

et al. 2012

Osteoarthritis and Cartilage

557

490

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Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis

Abstract: These observations suggest that Th1 cells predominate in the synovium of patients with OA, which clearly indicates that immune regulation occurs and may play critical roles in inflammation and cartilage destruction in patients with OA.

Cited by 121 publications

References 12 publications

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis

Comparison of YKL-39 and CHIT-1 expression during macrophages differentiation and polarization

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

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