Characterization of indomethacin release from polyethylene glycol tablet fabricated with mold technique

Abstract

The purpose of this study was to use polyethylene glycol as a carrier to improve the solubility of an aqueous insoluble drug by melting and molding method. The release of dissolved drug was designed to be subsequently sustained with an addition of xanthan gum. The release of indomethacin from the developed system into phosphate buffer pH 6.2 was conducted using the dissolution apparatus. This carrier system could effectively enhance the solubility of indomethacin and an addition of xanthan gum could sustain the drug release. Eudragit L100 film coating could protect the carrier not to be disturbed with HCl buffer pH 1.2 and could dissolve in phosphate buffer pH 6.2, therefore, the drug release from coated tablet was initially very low but subsequently gradually released and prolonged in phosphate buffer pH 6.2. Differential scanning calorimetry study indicated the amorphous state of drug in polyethylene glycol carrier. Scanning electron microscopy photomicrograph indicated the drug diffusion outward through the porous network of matrix tablets into the dissolution fluid and curve fitting signified that the drug release kinetic was Fickian diffusion.

Coprocessing of Pharmaceutical Cocrystals for High Quality and Enhanced Physicochemical Stability

“…The chemical instability witnessed with IND/SAC/PEG 6000 cocrystals may be due to the PEG 6000 being soluble with one of the bulk components. Phaechamud et al noted solubilization of IND when using a 7:3 PEG 4000/PEG 400 mixture as an inert drug carrier, and El-Badry and colleagues found that pure PEG 4000 also had a solubilizing effect when interacting with IND. , Given these findings, it is reasonable for one to assume that when left for a period of time, the IND began to solubilize within the PEG 6000 matrix causing the chemical instability noted in the XRPD analysis, which in turn led to an amount of recrystallized SAC being found in the sample after the 4-week period (All data for Rietveld fittings displayed in Supporting Information Figures S8 and S9).…”

“…Phaechamud et al noted solubilization of IND when using a 7:3 PEG 4000/PEG 400 mixture as an inert drug carrier, and El-Badry and colleagues found that pure PEG 4000 also had a solubilizing effect when interacting with IND. 44,45 Given these findings, it is reasonable for one to assume that when left for a period of time, the IND began to solubilize within the PEG 6000 matrix causing the chemical instability noted in the XRPD analysis, which in turn led to an amount of recrystallized SAC being found in the sample after the 4-week period (All data for Rietveld fittings displayed in Supporting Information Figures S8 and S9). 5 and 6) show the bulk IND to be in the form of long irregularly shaped crystals, while the extruded IND/SAC cocrystals are shown to be equant shaped and in the form of agglomerates.…”

An Insight into the Impact of Thermal Process on Dissolution Profile and Physical Characteristics of Theophylline Tablets Made through 3D Printing Compared to Conventional Methods

“…Then, tablets were weighed and kept for drying in an oven at 50 ℃ for 24 h. The weight of dried tablets was also recorded. Since part of tablets can dissolve during the dissolution test, water uptake% was calculated using the following equation: Water uptake% = (W1 − W2)/W2 × 100 where W1 is the weight of tablets at the end of the dissolution test and W2 is the weight of dried tablets [ 17 ]. Calculations were done in triplicate for more accuracy.…”