Characterization of in situ synthesized hydroxyapatite/polyetheretherketone composite materials

Ma, Rui; Weng, Luqian; Bao, Xujin; Ni, Zhuo; Song, Shenhua; Cai, Weiquan

doi:10.1016/j.matlet.2011.12.007

Cited by 44 publications

(45 citation statements)

References 21 publications

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“…In the last twenty years, enormous attention has been given to the HA-based filler reinforcement for polymer matrices for plausible biomedical applications such as tissue engineering [9]. Hence, there is increasing interest in the development of novel hybrids and nano-powders to be incorporated into suitable polymers to confer better mechanical properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE) incorporated with nano-hydroxyapaptite nanorods (mPE-nHA) was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscopy (AFM) and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT) was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT) by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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“…Histological studies revealed the presence of fibrovascular tissue within the pores after 6 weeks and mature bone formation after 16 weeks, indicating that the HA/PEEK composite exhibited favorable osseointegration. Ma et al 21 successfully prepared a HA/PEEK composite via an in situ synthetic process and implanted it into femurs of Sprague Dawley rats. In this case, the new bone tissues surrounding the composite implants grew faster with a higher HA content.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Tang

et al. 2016

IJN

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“…15 Previous studies have reported that the addition of micron-sized HA into PEEK may improve the bioactivity of the resultant HA/PEEK composite, and that the bioactivity of the composite seems to increase with increasing HA content. [16][17][18] Li et al fabricated a nanohydroxyapatite (nHA)-incorporated PEEK composite by powder processing and sintering, and their results suggested that the composite possessed good bioactivity and biocompatibility. 19 To the best of our knowledge, no previous studies have reported the in vitro osteoblast responses (such as cell attachment, spreading, proliferation, and osteogenic differentiation of a pre-osteoblastic cell line [MC3T3-E1]) to the nHA/PEEK composite.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

Ma¹,

Tang²,

Tan³

et al. 2014

IJN

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A bioactive composite was prepared by incorporating 40 wt% nano-hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.

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Characterization of in situ synthesized hydroxyapatite/polyetheretherketone composite materials

Cited by 44 publications

References 21 publications

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

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