Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. I. Chemistry

Riggin, R.M.; Kinzer, G.W.

doi:10.1016/0278-6915(83)90261-2

Cited by 12 publications

(1 citation statement)

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“…-thin layer chromatography (Auricchio, 1987(Auricchio, , 1989Guven et al, 1984) and paper chromatography (Ichibagasse, Kojima, 1962;Mitchell, 1955) were described for qualitative analysis mainly in food, beverages, artificial sweeteners and pharmaceutical preparations; high performance liquid chromatography (Hann, Gilkison, 1987;Leunberger, Gauch, Baumgartner, 1979;Szokolay, 1980) and gas chromatography (Kacprzak, 1978;Riggin, Kinzer, 1983) show application in beverages, pharmaceutical preparations and food; -visible spectrophotometry of saccharin involving the formation of colored compounds at 651 nm (Betalgy, 1974), 630 nm; (Hernandez-Cordoba, Lopez-Garcia, Sanches-Pedreno, 1985), 544 nm (Guven et al, 1984) and 685 nm (Ramappa, Nayak, 1983) are described. Zero order ultraviolet spectrophotometry was applied for saccharin determination at 244 nm (Hussein, Jacin, Rodriguez, 1976) in chewing gums.…”

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confidence: 99%

Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry

Vianna-Soares¹,

Martins

2002

Rev. Bras. Cienc. Farm.

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Saccharin, a synthetic sweetener constituent of several pharmaceutical and cosmetic preparations, is analyzed qualitatively and quantitatively in the presence of interferences like active ingredients and excipients. A derivative ultraviolet spectrophotometric method employing the second and the fourth orders was used. The calibration data obtained were satisfactory, with a relative precision range of 0.53%-0.72%, and linearity between 0.9998-0.9999. The recovery test results for the toothgel sample ranged between 97.80% and 104.95% in the second order of derivative and between 98.04% and 101.32% in the fourth derivative, respectively, using zero-peak (ZP) and peak-peak (PP) methods. The suspension sample showed values between 97.35% and 104.72% in the second derivative and between 95.94% to 104.41% in the fourth derivative, respectively, employing the zeropeak (ZP) and peak-peak (PP) methods. The proposed method showed precision, accuracy and simplicity.

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