Characterization of implantable biosensor membrane biofouling

Wisniewski, Natalie A.; Moussy, Francis; Reichert, William M.

doi:10.1007/s002160051556

Cited by 324 publications

(251 citation statements)

References 0 publications

Supporting

Mentioning

248

Contrasting

Order By: Relevance

“…See figure 4 for an example showing the OneTouch blood glucose monitoring device and an implantable biosensor probe with a schematic of biofouling-induced failure points. Membrane biofouling and fibrous encapsulation prevents glucose from contacting the probe for accurate measurements [66,67].…”

Section: (C) Temporary Implantsmentioning

confidence: 99%

Biofouling: lessons from nature

Bixler

Bhushan

2012

Phil. Trans. R. Soc. A.

472

358

View full text Add to dashboard Cite

Biofouling is generally undesirable for many applications. An overview of the medical, marine and industrial fields susceptible to fouling is presented. Two types of fouling include biofouling from organism colonization and inorganic fouling from non-living particles. Nature offers many solutions to control fouling through various physical and chemical control mechanisms. Examples include low drag, low adhesion, wettability (water repellency and attraction), microtexture, grooming, sloughing, various miscellaneous behaviours and chemical secretions. A survey of nature's flora and fauna was taken in order to discover new antifouling methods that could be mimicked for engineering applications. Antifouling methods currently employed, ranging from coatings to cleaning techniques, are described. New antifouling methods will presumably incorporate a combination of physical and chemical controls.

show abstract

Section: (C) Temporary Implantsmentioning

confidence: 99%

Biofouling: lessons from nature

Bixler

Bhushan

2012

Phil. Trans. R. Soc. A.

472

358

View full text Add to dashboard Cite

show abstract

“…In general, these devices will be exposed continuously to the various elements within the body. Over time the biomolecules within the body will react with the materials of the device, possibly leading to the passivation and reduced functionality of the device [68,69]. For example, the accumulation of proteins in the pores of the material around the drug output port eventually obstructs it [70].…”

Section: Biocompatibilitymentioning

confidence: 99%

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Tng

Song

et al. 2012

Micromachines

View full text Add to dashboard Cite

Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

show abstract

“…Conductive electroactive polymers (CEPs) [1,2] and hydrogels [3][4][5] are two of the most promising class of materials for biomedical applications The former ones, because its electrically modulated properties, could be engineered for devices like biosensors [6][7][8][9], drug delivery systems [10][11][12] and substrates for neural prostheses [13][14][15][16]. The second ones, due its transport properties, high hydration levels and biocompatibility are extensively found in controlled delivery devices [17], biosensors, contact lenses, catheters, wound dresses and tourniquets [5].…”

Section: Introductionmentioning

confidence: 99%

Zero-Order Release Profiles from A Multistimuli Responsive Electro-Conductive Hydrogel

Takahashi¹,

Lira²,

Torresi³

2012

JBNB

View full text Add to dashboard Cite

Electroconductive hydrogels has been extensively studied in drug delivery systems because they combine the properties of hydogels with the conducting polymers in only one material. In this work, pyrrole was polymerized electrochemically into poly(acrylic acid) hydrogel. This material kept the swelling properties that are characteristic of hydrogels and the electroactivity of the conducting polymers. The hydrogel (with and without the conducting polymer) swelling degree depends on both the ionic strength and pH. As this material is responsive to changes in the electrical potential, pH and ionic strength, the safranin release presented different delivery profiles, in accordance to variations and combinations of these stimuli. The most interesting result was the achievement of the linear safranin release indicating a zero-order kinetics.

show abstract

Characterization of implantable biosensor membrane biofouling

Cited by 324 publications

References 0 publications

Biofouling: lessons from nature

Biofouling: lessons from nature

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Zero-Order Release Profiles from A Multistimuli Responsive Electro-Conductive Hydrogel

Contact Info

Product

Resources

About