Characterization of IL-17/IL-17R gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Edwardsiella piscicida infections

Zhang, Xiaoyan; Cao, Min; Xue, Ting; Yu, Haohui; Yang, Tianzhen; Xu, Yan; Li, Chao

doi:10.1016/j.aquaculture.2022.737901

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Sebastes schlegelii , known as black rockfish, is an important mariculture fish in East Asian countries due to its high economic and ecological values. With the increase of farming scale, various diseases caused great economic losses to the region's aquaculture [ 28 ]. Therefore, studies on the immunity of this species can expand our understanding of its immune response and regulatory mechanisms, and are also helpful to guide the prevention and control of diseases.…”

Section: Introductionmentioning

confidence: 99%

Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine ofSebastes schlegelii

et al. 2023

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The intestine is a site of immune cell priming at birth. Therefore, spatial transcriptomes were performed to define how the transcriptomic landscape was spatially organized in the posterior intestine of Sebastes schlegelii following Edwardsiella piscicida infection. In the healthy condition, we identified a previously unappreciated molecular regionalization of the posterior intestine. Following bacterial infection, most immune-related genes were identified in mucosa layer. Moreover, investigation of immune-related genes and genes in immune-related KEGG pathways based on spatial transcriptomes shed light on which sections of these genes are in the posterior intestine. Meanwhile, the high expression of genes related to regeneration also indicated that the posterior intestine was responding to the invasion of pathogens by constantly proliferating new cells. In addition, the increasing microbiota communities indicated that these bacteria maintained posterior intestine integrity and shaped the mucosal immune system. Taken together, spatial transcriptomes and microbiota compositions have significant implications for understanding the immune mechanism that responds to E. piscicida infection in the posterior intestine of S. schlegelii , which also provides a theoretical basis for the spatial distribution of immune genes and changes in bacterial flora in other teleosts in the process of resisting pathogens.

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Section: Introductionmentioning

confidence: 99%

Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine ofSebastes schlegelii

et al. 2023

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“…On the other hand, the immune functions of IL-17 ligands and receptors have also been reported in different fish species. For instance, the expressions of all identified IL-17 ligands and receptors were significantly changed in various fish species after bacterial infection or PAMP stimulation [35,[39][40][41]46,48,49]. After infection with Aeromonas hydrophila, large yellow croaker IL-17RA, IL-17RC, IL-17RD and IL-17RE were significantly upregulated in mucosal tissue (gills) and systemic immune tissue (head kidney and spleen), however large yellow croaker IL-17RB expression was detected in gills, indicating that IL-17 receptors may be involved in host defense against bacterial infection [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of LPS, Poly (I:C) and Edwardsiella tarda on the Expression Patterns of IL-17 Family Members and Their Receptors in Spotted Sea Bass (Lateolabrax maculatus)

Wan

Sun

Zhang

et al. 2023

Fishes

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In fish, the immune system plays a crucial role in defending against pathogen-induced infections. The interleukin 17 (IL-17) family, which is a well-studied class of cytokines, serves as a key component of the immune response against external pathogens. In this research, four IL-17 ligands (IL-17A/F1, IL-17B, IL-17C and IL-17D) and one receptor (IL-17RB) genes were identified from spotted sea bass (Lateolabrax maculatus). Alignment analysis showed that the C-terminal region of IL-17 ligands in spotted sea bass was highly conserved. The expression of the IL-17 ligand and receptor genes differed in unstimulated tissues. To investigate the impact of various factors on the immune response of spotted sea bass, we assessed the effect of lipopolysaccharide (LPS), polyinosinic–polycytidylic acid [poly (I:C)] and Edwardsiella tarda treatment on the IL-17 ligands and receptor responses. Our results reveal that the expression of the IL-17 ligand and receptor transcripts is modulated by LPS, poly (I:C) and E. tarda, indicating their significant role in the immune system.

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Characterization of caspase gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Vibrio anguillarum infection

Yu,

Yan,

Wang

et al. 2024

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Characterization of IL-17/IL-17R gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Edwardsiella piscicida infections

Cited by 6 publications

References 30 publications

Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine ofSebastes schlegelii

Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine ofSebastes schlegelii

Effects of LPS, Poly (I:C) and Edwardsiella tarda on the Expression Patterns of IL-17 Family Members and Their Receptors in Spotted Sea Bass (Lateolabrax maculatus)

Characterization of caspase gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Vibrio anguillarum infection

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