Characterization ofNeisseria gonorrhoeaecolonization of macrophages under distinct polarization states and nutrients environment
María Dolores Juárez Rodríguez,
Madison Marquette,
Reneau Youngblood
et al.
Abstract:Neisseria gonorrhoeae (Ng) is a uniquely adapted human pathogen and the etiological agent of gonorrhea, a sexually transmitted disease. Ng has developed numerous mechanisms to avoid and actively suppress innate and adaptive immune responses. Ng successfully colonizes and establishes topologically distinct colonies in human macrophages and avoids phagocytic killing. During colonization, Ng manipulates the actin cytoskeleton to invade and create an intracellular niche supportive of bacterial replication. The cel… Show more
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