Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Panraksa, Pattaraporn; Qi, Sheng; Udomsom, Suruk; Tipduangta, Pratchaya; Rachtanapun, Pornchai; Jantanasakulwong, Kittisak; Jantrawut, Pensak

doi:10.3390/polym13203454

Cited by 23 publications

(16 citation statements)

References 43 publications

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“…The films from experiment I. showed slightly faster disintegration times (Table 4). The values of disintegration time ranged from 2.6 ± 0,32 to 40.6 ± 1.37 s. In the second experiment, the values ranged from 2.7 ± 0.17 to 41.3 ± 1.66 s. This is comparable to a study employing a similar printing technique, only with a 6 h long post-print drying time, where the disintegration time found was between 2.02 and 49.85 s [35]. In both experiments, the thickest batches do not meet the specific limit for orodispersible tablets.…”

Section: Disintegrationsupporting

confidence: 76%

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Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films

et al. 2022

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Orodispersible films are an innovative dosage form. Their main advantages are the application comfort and the possibility of personalization. This work aimed to evaluate the influence of different drying times on the properties of orodispersible films of various thicknesses, prepared in two different semisolid extrusion 3D printing setups. In the first experiment, drying times were dependent on the overall print time of each batch. In the second setup, the drying time was set equal according to the longest one. The evaluated parameters were films’ weight uniformity, thickness, moisture content, surface pH, disintegration time, hardness, and tensile strength. Upon statistical comparison, significant differences in the moisture content were found, subsequently affecting the disintegration time. Moreover, statistically significant differences in films’ mechanical properties (hardness, tensile strength) were also described, proving that moisture content simultaneously affects film plasticity and related properties. In conclusion, a mutual comparison of the manufactured orodispersible films showed that the drying time affects their physical and mechanical properties. The in-process drying setup was proved to be sufficient while allowing quicker manufacturing.

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Section: Disintegrationsupporting

confidence: 76%

“…However, the elongations vary between experimental studies due to differences in the materials used. For example, only 2.10-3.76% of elongation was found in one of the studies [35].…”

Section: Tensile Testingmentioning

confidence: 91%

Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films

et al. 2022

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“…Their thickness was comparable to that of the SmartStrip (0.15 ± 0.02 mm). The mechanical properties of ODFs can play a critical role in the physical uniformity and stability of the dosage forms [ 44 ]. The puncture strength of 3D films is a critical parameter for product quality.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole

et al. 2022

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The objective of this study was to design and evaluate an orodispersible film (ODF) composed of aripiprazole (ARP), prepared using a conventional solvent casting technique, and to fuse a three-dimensional (3D) printing technique with a hot-melt extrusion (HME) filament. Klucel® LF (hydroxypropyl cellulose, HPC) and PE-05JPS® (polyvinyl alcohol, PVA) were used as backbone polymers for 3D printing and solvent casting. HPC-, PVA-, and ARP-loaded filaments were applied for 3D printing using HME. The physicochemical and mechanical properties of the 3D printing filaments and films were optimized based on the composition of the polymers and the processing parameters. The crystalline states of drug and drug-loaded formulations were investigated using differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). The dissolution and disintegration of the 3D-printed films were faster than those of solvent-cast films. HPC-3D printed film was fully disintegrated within 45 ± 3.5 s. The dissolution rate of HPC films reached 80% within 30 min at pH 1.2 and pH 4.0 USP buffer. There was a difference in the dissolution rate of about 5 to 10% compared to PVA films at the same sampling time. The root mean square of the roughness (Rq) values of each sample were evaluated using atomic force microscopy. The higher the Rq value, the rougher the surface, and the larger the surface area, the more salivary fluid penetrated the film, resulting in faster drug release and disintegration. Specifically, The HPC 3D-printed film showed the highest Rq value (102.868 nm) and average surface roughness (85.007 nm). The puncture strength of 3D-printed films had desirable strength with HPC (0.65 ± 0.27 N/mm2) and PVA (0.93 ± 0.15 N/mm2) to prevent deformation compared to those of marketed film products (over 0.34 N/mm2). In conclusion, combining polymer selection and 3D printing technology could innovatively design ODFs composed of ARP to solve the unmet medical needs of psychiatric patients.

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“…Additionally, drug crystallisation may be prevented in oral films by 3DP compared to solvent casting method [ 6 ]. FDFs were prepared by a gel 3DP with disintegration time of 3 s when sodium carboxymethylcellulose was included in the formulation at 5% w / w concentration [ 7 ]. In another approach, Elbadawi et al, 2021 employed dual-nozzle pressure-assisted microsyringe 3DP for fabrication of FDFs [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Micro-Ribbons and Micro-Fibres in the Formulation of 3D Printed Fast Dissolving Oral Films

et al. 2023

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Three-dimensional printing (3DP) allows production of novel fast dissolving oral films (FDFs). However, mechanical properties of the films may not be desirable when certain excipients are used. This work investigated whether adding chitosan micro-ribbons or cellulose microfibres will achieve desired FDFs by fused deposition modelling 3DP. Filaments containing polyvinyl alcohol (PVA) and paracetamol as model drug were manufactured at 170 °C. At 130 °C, filaments containing polyvinylpyrrolidone (PVP) and paracetamol were also created. FDFs were printed with plain or mesh patterns at temperatures of 200 °C (PVA) or 180 °C (PVP). Both chitosan micro-ribbons and cellulose micro-fibres improved filament mechanical properties at 1% w/w concentration in terms of flexibility and stiffness. The filaments were not suitable for printing at higher concentrations of chitosan micro-ribbons and cellulose micro-fibres. Furthermore, mesh FDFs containing only 1% chitosan micro-ribbons disintegrated in distilled water within 40.33 ± 4.64 s, while mesh FDFs containing only 7% croscarmellose disintegrated in 55.33 ± 2.86 s, and croscarmellose containing films showed signs of excipient scorching for PVA polymer. Cellulose micro-fibres delayed disintegration of PVA mesh films to 108.66 ± 3.68 s at 1% w/w. In conclusion, only chitosan micro-ribbons created a network of hydrophilic channels within the films, which allowed faster disintegration time at considerably lower concentrations.

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Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Cited by 23 publications

References 43 publications

Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films

Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films

Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole

The Use of Micro-Ribbons and Micro-Fibres in the Formulation of 3D Printed Fast Dissolving Oral Films

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