Characterization of Human Invasive Isolates of<i>Listeria monocytogenes</i>in Sweden 1986–2007

Parihar, Vishal Singh; Lopez-Valladares, Gloria; Danielsson-Tham, Marie-Louise; Peiris, Inoka; Helmersson, Seved; Unemo, Magnus; Andersson, Birgitta; Arneborn, Malin; Bannerman, Elizabeth; Barbuddhe, Sukhadeo B.; Billé, Jacques; Hajdu, Lajos; Jacquet, Christine; Johansson, C.; Löfdahl, Margareta; Möllerberg, Gunnel; Ringberg, Håkan; Rocourt, J.; Tjernberg, Ingela; Ursing, Jan; Henriques‐Normark, Birgitta; Tham, Wilhelm

doi:10.1089/fpd.2008.0123

Cited by 39 publications

(38 citation statements)

References 35 publications

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“…In this study, it was found that the isolates of L. monocytogenes serotypes 4b, 1/2a and 1/2b were strongly correlated within the same serotypes and, in some cases, between the different serotypes, indicating a common origin. The same results were observed by other authors (PARIHAR, et al, 2008).…”

Section: Resultssupporting

confidence: 92%

“…There is a discussion about the relationship of the origin of two lineages found in L. monocytogenes, the lineage I represented by serovars 1/2b and 4b, and the lineage II represented by serovars 1/2a and 1/2c (PARIHAR et al, 2008). According to NIGHTINGALE et al (2005), lineage I comprises the strains which have adapted to the human host, while lineage II comprises the strains which have been environmentally adapted.…”

Section: Resultsmentioning

confidence: 99%

“…Listeriosis is fatal in about 30% of cases and mainly affects immunocompromised people, pregnant women, newborn babies and the elderly (PARIHAR et al, 2008;FILIOUSIS et al, 2009). This ubiquitous pathogen is particularly important because of its ability to multiply at low temperatures and under high salt concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Molecular characterization of Listeria monocytogenes isolated from animal products in a city of Northern Brazil

et al. 2013

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

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Molecular characterization of Listeria monocytogenes isolated from animal products in a city of Northern Brazil

et al. 2013

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“…While a few studies (Hong et al, 2007;Jeffers et al, 2001;Kiss et al, 2006) have shown that lineage I isolates are also overrepresented among sporadic cases of human listeriosis (e.g., as compared to their prevalence among food isolates), this trend does not seem to be consistent and the association between lineages and human listeriosis cases may vary by region. In particular lineage II serotype 1/2a strains appear to be more common among human listeriosis cases in Northern Europe [e.g., in Finland (Lukinmaa et al, 2003) and Sweden (Parihar et al, 2008)], Fig. 2.…”

Section: Distribution Of L Monocytogenes Lineages Among Human Isolatesmentioning

confidence: 99%

Listeria monocytogenes lineages: Genomics, evolution, ecology, and phenotypic characteristics

Orsi

Bakker

Wiedmann

2011

International Journal of Medical Microbiology

614

545

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“…Studies in a number of countries indicate that lineage I strains are overrepresented among human cases compared to lineage II strains, even though lineage II strains still frequently cause disease in humans (9,11). Nevertheless, overrepresentation of lineage I strains among human cases has not been observed in some countries, such as Finland (12) and Sweden (13). In many studies, lineage II seems to be the most common lineage among isolates from foods and food-related environments, such as food processing plants (14), posing the question of why these lineage II isolates are not more frequently found among human clinical cases.…”

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confidence: 99%

Prevalence and Distribution of Listeria monocytogenes inlA Alleles Prone to Phase Variation and inlA Alleles with Premature Stop Codon Mutations among Human, Food, Animal, and Environmental Isolates

Manuel

Stelten

Wiedmann

et al. 2015

Appl Environ Microbiol

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cIn Listeria monocytogenes, 18 mutations leading to premature stop codons (PMSCs) in the virulence gene inlA have been identified to date. While most of these mutations represent nucleotide substitutions, a frameshift deletion in a 5= seven-adenine homopolymeric tract (HT) in inlA has also been reported. This HT may play a role in phase variation and was first identified among L. monocytogenes lineage II ribotype DUP-1039C isolates. In order to better understand the distribution of different inlA mutations in this ribotype, a newly developed multiplex real-time PCR assay was used to screen 368 DUP-1039C isolates from human, animal, and food-associated sources for three known 5= inlA HT alleles: (i) wild-type (WT) (A 7 ), (ii) frameshift (FS) (A 6 ), and (iii) guanine interruption (A 2 GA 4 ) alleles. Additionally, 228 DUP-1039C isolates were screened for all inlA PMSCs; data on the presence of all inlA PMSCs for the other 140 isolates were obtained from previous studies. The statistical analysis based on 191 epidemiologically unrelated strains showed that strains with inlA PMSC mutations (n ‫؍‬ 41) were overrepresented among food-associated isolates, while strains encoding full-length InlA (n ‫؍‬ 150) were overrepresented among isolates from farm animals and their environments. Furthermore, the A 6 allele was overrepresented and the A 7 allele was underrepresented among food isolates, while the A 6 allele was underrepresented among farm and animal isolates. Our results indicate that genetic variation in inlA contributes to niche adaptation within the lineage II subtype DUP-1039C. Listeria monocytogenes is a food-borne pathogen and the etiological agent of listeriosis, a severe invasive disease that can affect both humans and animals (1). More than 99% of human listeriosis cases are estimated to be transmitted through food (2). Despite its presence in a wide range of environments and foods, the majority of human listeriosis infections appear to be linked to consumption of contaminated ready-to-eat (RTE) foods (3) that support L. monocytogenes growth. Numerous studies have indicated that not all L. monocytogenes strains are equally associated with invasive disease. For example, McLauchlin reported that three (1/2a, 1/2b, and 4b) of the 13 serotypes of L. monocytogenes were responsible for 90% of 1,363 listeriosis cases from the United Kingdom (4). Additionally, multiple studies using both DNA band-based and sequence-based subtyping methods have shown that L. monocytogenes forms a structured population composed of at least four divergent lineages (I, II, III, and IV), which in a number of studies have been suggested to differ in their associations with different sources and in their pathogenic potentials (5-9). The majority of L. monocytogenes isolates belong to lineages I and II, which contain the serotypes most commonly associated with human clinical cases; serotypes 1/2b and 4b group into lineage I, while serotypes1/2a and 1/2c group into lineage II. Lineage III and IV strains are rare and usually isolated from ...

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Characterization of Human Invasive Isolates ofListeria monocytogenesin Sweden 1986–2007

Cited by 39 publications

References 35 publications

Molecular characterization of Listeria monocytogenes isolated from animal products in a city of Northern Brazil

Molecular characterization of Listeria monocytogenes isolated from animal products in a city of Northern Brazil

Listeria monocytogenes lineages: Genomics, evolution, ecology, and phenotypic characteristics

Prevalence and Distribution of Listeria monocytogenes inlA Alleles Prone to Phase Variation and inlA Alleles with Premature Stop Codon Mutations among Human, Food, Animal, and Environmental Isolates

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