Characterization of Human Heterophile Antibodies
Apparently Induced by Alloimmunization

McDonald, B.L.; Hawkins, B.R.; Dawkins, R.L.; Davey, M.G.

doi:10.1159/000467503

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…On a number of grounds, we suggested previously that alloimmunization with an agent present in ABO compatible blood could stimulate the appearance of hetero phile antibody [2]. The present finding that the antibody occurs more frequently in in dividuals with a history of blood transfusion is consistent with this view.…”

Section: Resultssupporting

confidence: 90%

“…The possibility that heterophile antibody results from im munization by a ubiquitous agent or agents must also be considered, especially since an tibodies with similar characteristics to het erophile antibody have been reported in the serum of patients with a number of infections including malaria and tryanosomiasis [6][7][8]. The repeated finding that the antibody oc curs less frequently in those with blood group B suggests that the ubiquitous agent in question has some antigenic relationship to the ABO system [2]. This is not without pre cedent since E. coli 086, for example, is known to have a close serological relation ship to blood group B [9].…”

Section: Resultsmentioning

confidence: 99%

“…Prelimi nary studies showed that the antibody oc curred with a higher frequency in multipar ous women and blood donors immunized with Rh-incompatible red cells and that the antibody could appear after blood transfu sion [2,3], These findings led us to suspect that in many cases the antibody arises through alloimmunization with an agent pres ent in ABO-compatible blood. A popula tion study of autoantibodies in Busselton, Western Australia, provided an opportunity to investigate the population distribution of heterophile antibody in more detail, particu larly with respect to its occurrence in relation to the potential opportunities for immuniza tion provided by pregnancy and blood trans fusion.…”

mentioning

confidence: 99%

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Population Study of Heterophile Antibodies

Hawkins¹,

Saueracker²,

Dawkins³

et al. 1980

Vox Sanguinis

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Sera from 2,829 participants in a population health survey were tested for the presence of a heterophile antibody, detectable by immunofluorescence. The antibody was found in 9.8% of the sera from women and in 12.4% of the sera from men. The age-specific prevalence of the antibody was relatively constant in women but rose steeply in men. The antibody occurred more frequently in individuals with a history of blood transfusion and in multiparous females. It is suggested that the antibody may result from immunization by a ubiquitous agent which can be transmitted by blood transfusion.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Population Study of Heterophile Antibodies

Hawkins¹,

Saueracker²,

Dawkins³

et al. 1980

Vox Sanguinis

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“…The specific immunofluorescent patterns observed were unlike any seen, classified and reported previously by this laboratory [12][13][14][15] from testing 10 000 human sera per annum over 20 years. These samples are submitted to this Department from throughout Western Australia and beyond for autoantibody screening on rodent tissues, human neutrophils and HEp-2 cells.…”

Section: Tissue Binding Of Three Rabbit Antisera Induced By the Perb1contrasting

confidence: 74%

Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family

Leelayuwat

Hollingsworth

Pummer

et al. 1996

Clinical and Experimental Immunology

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SUMMARYPERB11 (MIC) is a gene family possessing multiple copies located within the MHC. Structurally, PERB11 is related to the MHC class I, neonatal IgG Fc receptor (FcRn) and Zn-® 2 -glycoprotein molecules. The MHC class I family is complex in terms of its genomic arrangement, expression and function, and available evidence suggests that the PERB11 family may be similarly complex. We have adopted an approach to study the expression of such complex gene families by immunizing with multiple peptides and by screening the resulting antibodies against a large range of tissues. The amino acid sequences of PERB11.1 and PERB11.2 as well as those of other related molecules were analysed and compared. Peptides were chosen for immunization based upon (i) loop formation within the equivalent known structure of the MHC class I molecules; (ii) immunogenicity by computer analysis; and (iii) evolutionary relationships. Antibodies in serum from immunized rabbits bound to three out of six peptides used for immunization. ELISA and immunoprecipitation demonstrated binding both to the peptides and to the PERB11.2 recombinant protein. By immunofluorescent staining of various tissues of several species, the three antisera generated overlapping profiles of activity. These included reactions with kidney, small and large intestine, oesophagus, testis, ovary and human neutrophils. This is the first description of antibodies induced by the PERB11 peptides. The extreme complexity of these profiles requires further investigation, but may be explained in terms of antibodies against diverse products of the PERB11 gene family and/or related molecules.

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“…Such heterophile antibodies have been found in 50% of patients with the post-cardiotomy syndrome, 41% of patients receiving blood trans fusions, about 10% of renal allograft recipients, and in 6% of normal blood donors [12,16,17]. The stimuli for heterophile antibody production are not known for certain, but they may result from alloimmuniza tion via ABO-compatible blood [17], allografting [18] or infection [19],…”

Section: Discussionmentioning

confidence: 99%

Anti-Heart Antibodies in Cardiac Allograft Recipients

Cave

et al. 1984

Int Arch Allergy Immunol

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Serum antibodies reactive with rat cardiac and skeletal muscle were found by indirect immunofluorescence in 11 of 16 heart transplant patients receiving heterologous antithymocyte globulin and 1 of 5 patients receiving cyclosporin A. These antibodies appeared de novo following transplantation and were present for variable lengths of time. Antibodies reactive with rat liver, stomach and kidney were also found in several patients. 9 out of 16 patients receiving equine globulin had antibodies directed against components of the microvasculature, including endothelial, smooth muscle and vessel wall connective tissue. Analysis of antibody kinetics and acute cardiac rejection did not reveal any well-defined associations, though anti-heart antibodies were present in 4 of 6 patients who died from acute rejection.

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Characterization of Human Heterophile Antibodies Apparently Induced by Alloimmunization

Cited by 4 publications

References 9 publications

Population Study of Heterophile Antibodies

Population Study of Heterophile Antibodies

Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family

Anti-Heart Antibodies in Cardiac Allograft Recipients

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