Characterization of human erythrocyte choline transport in chronic renal failure

Riley, Sean P.; Talbot, NP; Ahmed, Mashal; Jouhal, K; Hendry, Bruce M.

doi:10.1093/ndt/12.9.1921

Cited by 10 publications

(5 citation statements)

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“…(1). Impaired choline transport has been implicated in the pathogenesis of multiple clinical manifestations, particularly in neurological, muscular, and immunological disorders [37] and certain cancers such as breast and ovarian cancer [38,39]. Several distinct choline transport systems are required in the same organ to transport choline, depending on the intended fate of choline once it has entered the cell.…”

Section: Types Of Choline Transport Systemsmentioning

confidence: 99%

The Ubiquitous Choline Transporter SLC44A1

Michel

Bakovic²

2012

CNSAMC

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Choline is a zwitter ion that is positively charged at certain pH, which necessitates transport systems to allow this amine to cross the phospholipid bilayer of cellular membranes. The solute carrier 44A1 (SLC44A1), also referred to as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter with an intermediate affinity for choline; this transport is Na(+)-independent and sensitive to inhibition by the drug hemicholinium-3. We highlight in this review the discovery and characterization of SLC44A1, describe its expression patterns and subcellular localization, and summarize evidence for the role of this choline transporter in the central nervous system.

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Section: Types Of Choline Transport Systemsmentioning

confidence: 99%

The Ubiquitous Choline Transporter SLC44A1

Michel

Bakovic²

2012

CNSAMC

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“…Separately from choline metabolism, disturbed choline transport has been proposed to play an important role in multiple clinical manifestations, particularly in neurological, muscular, and immunological disorders (53,54) and in various cancers, including breast and ovarian cancer (55,56). However, choline transport has been studied predominantly in neurodegenerative disorders, particularly in Alzheimer's disease.…”

Section: Importance Of Choline Transportmentioning

confidence: 99%

“…Membrane transport of choline is elevated in renal failure in erythrocytes and cerebral tissue, but the origins and clinical importance of that are unknown. (53). Ocrl, for example, is localized in the basolateral membrane of renal proximal tubules, in intestinal enterocytes, and in the sinusoidal membrane of hepatocytes, where it probably mediates the efflux of many organic cations, including choline.…”

Section: Systems For Choline Transportmentioning

confidence: 99%

Choline Transport for Phospholipid Synthesis

Michel

Yuan

Ramsubir

et al. 2006

Exp Biol Med (Maywood)

277

267

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Choline is an essential nutrient for all cells because it plays a role in the synthesis of the membrane phospholipid components of the cell membranes, as a methyl-group donor in methionine metabolism as well as in the synthesis of the neurotransmitter acetylcholine. Choline deficiency affects the expression of genes involved in cell proliferation, differentiation, and apoptosis, and it has been associated with liver dysfunction and cancer. Abnormal choline transport and metabolism have been implicated in a number of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Therefore, the study of choline transport and the characteristics of choline transporters are of central importance to understanding the mechanisms that underlie membrane integrity and cell signaling in such disorders. Kinetic studies with radiolabeled choline and inhibitors distinguish three systems for choline transport: (i) low-affinity facilitated diffusion, (ii) high-affinity, Na+-dependent transport, and (iii) intermediate-affinity, Na+-independent transport. It is only recently, however, that the proteins having transport characteristics of at least one of these systems have been identified. They include (i) polyspecific organic cation transporters (OCTs) with low affinity for choline, (ii) high-affinity choline transporters (CHT1s), and (iii) intermediate-affinity choline transporter-like (CTL1) proteins. CHT1 and CTL1 but not OCT transporters are selectively inhibited with hemicholinium-3 and essentially display characteristics of specialized transporters for targeted choline metabolism. CHT1 is abundant in neurons and almost exclusively supplies choline for acetyl-choline synthesis. The focus here is more on newly-discovered CTL1 choline transporters. They are expressed in different organisms and cell types, apparently not for the biosynthesis of acetylcholine but for the production of the most abundant metabolite of choline, the membrane lipid phosphatidylcholine.

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“…In addition to diseases with plaque instability (ACS, stroke and cerebral ischemia), elevated levels of choline are found in end-stage renal disease (ESRD) [43], chronic myelogenous leukemia, pregnancy, neonates and specific treatments as shown in Box 3. ESRD is also associated with an increased surface expression of the erythrocyte choline transporter [44]. Hemodialysis (and renal transplantation) results in a decline of choline concentrations in ESRD patients and PCho returns to predialysis levels within 6 h [45,46].…”

Section: Choline Values In Health Acs and Other Diseasesmentioning

confidence: 99%