Characterization of Highly Osteoblast/Cementoblast Cell Clones From a CD105‐Enriched Periodontal Ligament Progenitor Cell Population

Abstract

These results provide evidence that PDL-CD105(+) purified progenitor cells comprise a heterogeneous cell population that presents a cell subset with high O/C potential and, further, that surface antigen CD166 is modulated during the O/C maturation of this cell subset.

Tooth-derived stem cells: Update and perspectives

“…Additionally, it has been noted that, even in the same population of MSCs, there are heterogeneous cell subpopulations with distinct differentiation potentials [100] . This heterogeneity in relation to the ability to differentiate in vitro and to form dental tissues in vivo has also been reported in some TDSCs lineages, including DPSCs [44,46,67] , SHED [49] , DFPCs [72] , and PDLSCs [34,73,74,[101][102][103][104] . Therefore, it can be concluded that, although there are MSCrelated surface markers, such as STRO-1, CD146 and CD105, specific surface markers associated with the hierarchical commitment to differentiation pathways of TDSCs are not yet well established.…”

“…The periodontal ligament harbors a heterogeneous cell population, with subsets of cells in various stages of commitment to fibroblastic and osteoblastic/ cementoblastic lineages [34,73,74] . Within these subsets,…”

Stem cells derived from “inflamed” and healthy periodontal ligament tissues and their sheet functionalities: a patient‐matched comparison

“…) and/or CD105 (Saito et al. ) surface markers can increase the osteogenic differentiation potential of MSCs. However, it is unclear why I‐PDLSCs have reduced levels of MSC markers but display a greater number of CFUs compared with H‐PDLSCs (Fig.…”

Osteogenic potential of periodontal ligament stem cells are unaffected after exposure to lipopolysaccharides

“…18 However, this population was not isolated and highly CD105 + purified periodontal ligament progenitor cells were employed. Since it was already demonstrated that MSCs from PDL harbors a heterogeneous stem-cell-enriched population, 32,36,37 it is possible that PDLSCs composed by CD105 + cell subsets are less susceptible to P. gingivalis LPS challenge compared to heterogeneous PDLSC populations. However, further studies are required to elucidate the response of PDLSCs to other P. gingivalis virulence factors.…”