Characterization of High and Low IFNG-Expressing Subgroups in Atopic Dermatitis
Sophia Wasserer,
Manja Jargosch,
Kristine E. Mayer
et al.
Abstract:Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, with an increasing number of targeted therapies available. While biologics to treat AD exclusively target the key cytokines of type 2 immunity, Janus kinase inhibitors target a broad variety of cytokines, including IFN-γ. To better stratify patients for optimal treatment outcomes, the identification and characterization of subgroups, especially with regard to their IFNG expression, is of great relevance, as the role of IFNG in… Show more
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