Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS

El‐Askary, Hesham I.; Handoussa, Heba; Badria, Farid A.; El‐Khatib, Ahmed H.; Alsayari, Abdulrhman; Linscheid, Michael; Motaal, Amira Abdel

doi:10.1016/j.bjp.2018.10.001

Cited by 25 publications

(19 citation statements)

References 32 publications

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“…Caffeoylquinic acids are known powerful antioxidants and plant sources of caffeoylquinic acids, such as A. dracunculus extracts, which may provide antioxidant protection. A high caffeoylquinic acids content was previously found in other Artemisia plants, such as A. annua L. ( El-Askarya et al, 2019 ) and A. herba-alba ( Bourgou et al, 2017 ). A. dracunculus herb infusion can also be a good source of caffeoylquinic acids in the everyday diet.…”

Section: Discussionmentioning

confidence: 64%

“…The main pseudomolecular ion obtained for compounds 1 (t r =11.7 min), 5 (tr =14 min), 7 (t r =20.9 min), and 8 (t r =22.8 min) was at m/z 353 [M–H] - . In addition, the presence of an intensive signal at m / z 191 in MS/MS spectra, which is indicative of quinic acid moiety, was established ( El-Askarya et al, 2019 ). The compounds were further assigned based on the fragmentation patterns and their elution order as mono- O -caffeoylquinic acids ( Eisenman et al, 2011 ; Miron et al, 2011 ; Gu et al, 2012 ; Lin and Harnly, 2012 ; Olennikov et al, 2018 ; Olennikov et al, 2019 ; Kiss et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion—Phytochemical Characterization

et al. 2020

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The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects on mediators of the inflammation in an in vitro model of human neutrophils, and antimicrobial activity on selected pathogens. Flavonoids and caffeoylquinic acids were the main phenolic components of the extract of tarragon's aerial parts. The infusion was able to inhibit reactive oxygen species (ROS), interleukin 8 (IL-8), and tumour necrosis factor a (TNF-a) production. The antimicrobial assay was performed with the use of nine strains of bacteria, both Gram-negative and Gram-positive. Three human pathogens, Staphylococcus aureus ATCC6538, Staphylococcus epidermidis ATCC14990, and Staphylococcus aureus MRSA (methicyllin-resistant Staphylococcus aureus) ATCC43300, proved to be the most sensitive to tarragon infusion. Our study demonstrated the antiinflammatory and antimicrobial properties of tarragon (Artemisia dracunculus L.), meaning the common spice may be a prospective source of health-promoting constituents.

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Section: Discussionmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion—Phytochemical Characterization

et al. 2020

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“…Thanks to this richness, Artemisia annua has a large number of other biological properties such as hepatoprotective, antifungal, antitumor, antioxidant, anti-inflammatory and anti-asthmatic activities [ 8 , 17 , 18 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Artemisia annua, a Traditional Plant Brought to Light

Septembre-Malaterre

Rakoto

Marodon³

et al. 2020

IJMS

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Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties. Artemisia annua is very rich in secondary metabolites such as monoterpenes, sesquiterpenes and phenolic compounds, of which the biological properties have been extensively studied. The purpose of this review is to gather and describe the data concerning the main chemical components produced by Artemisia annua and to describe the state of the art about the biological activities reported for this plant and its compounds beyond malaria.

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“…This could be supported by another study which showed that rosemary extract inhibited phosphorylation/activation of Akt in TNBC cells (Jaglanian and Tsiani, 2020). UA was purified from the rosemary EA fraction for closer investigation on TNBC hallmarks (El-Askary et al, 2019). UA treatment was able to reduce the cellular viability, clonogenicity as well as migration capacity of the TNBC cells.…”

Section: Discussionmentioning

confidence: 78%

Uncoupling tumor necrosis factor-α and interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

Soliman¹,

Youness²,

Manie³

et al. 2022

Biocell

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Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS

Cited by 25 publications

References 32 publications

Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion—Phytochemical Characterization

Inhibition of Neutrophil Functions and Antibacterial Effects of Tarragon (Artemisia dracunculus L.) Infusion—Phytochemical Characterization

Artemisia annua, a Traditional Plant Brought to Light

Uncoupling tumor necrosis factor-α and interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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