Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil

Santos, Alcione Oliveira Dos; Alvarado-Mora, Mónica Viviana; Botelho, Livia; Vieira, Deusilene Souza; Pinho, João Pedro; Carrilho, Flair José; Honda, Eduardo Resende; Salcedo, Juan M.

doi:10.1186/1743-422x-7-315

Cited by 45 publications

(55 citation statements)

References 66 publications

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“…Although no comparable data have been published, the proportion of occult HBV infection identifi ed was similar to that reported in a community of African origin (1.7%), which utilized similar methods for the detection of HBV DNA 29 . The HBV genotypes/ subtypes A/A1, D/D3 and F/F2 were identifi ed in the three HBV DNA-positive serum samples, consistent with those circulating in the central-western region and other regions in Brazil 19,30,31 . Furthermore, it is noteworthy that the identifi ed genotype F/subtype F2 may indicate movement of the population from the Amazon region, where the frequency of this genotype/subtype is considerable 30,32 .…”

Section: Discussionmentioning

confidence: 74%

Epidemiology of hepatitis B virus infection among recyclable waste collectors in central Brazil

Marinho

Lopes

Teles

et al. 2014

Rev. Soc. Bras. Med. Trop.

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introduction:The collection of recyclable waste materials is a widespread activity among the urban poor. Today, this occupation attracts an increasingly large number of individuals. Despite its economic and environmental importance, this activity is associated with unsafe and unhealthy working conditions. The aim of this study was to investigate the seroepidemiological profi le of hepatitis B virus (HBV) infection in a population of recyclable waste collectors in central Brazil. Methods: Recyclable waste collectors from all 15 recycling cooperatives in Goiânia City were invited to participate in the study. The participants (n = 431) were interviewed and screened for hepatitis B surface antigen (HBsAg) and antibodies against HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc) by enzyme-linked immunosorbent assay (ELISA). HBsAg-and anti-HBc-positive samples were tested for HBV DNA and genotyped. Results: The overall prevalence of HBV infection (HBsAg-and/or anti-HBc-positive) was 12.8%. An age over 40 years and illicit drug use were associated with HBV infection. HBV DNA was detected in 2/3 HBsAg-positive samples and in 1/52 anti-HBc-positive/HBsAg-negative samples (an occult HBV infection rate of 1.9%), in which the genotypes/subgenotypes A/A1, D/D3 and F/F2 were identifi ed. Only 12.3% of the recyclable waste collectors had serological evidence of previous HBV vaccination. Conclusions: These fi ndings highlight the vulnerability of recyclable waste collectors to HBV infection and reinforce the importance of public health policies that address the health and safety of this socially vulnerable population.

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Section: Discussionmentioning

confidence: 74%

Epidemiology of hepatitis B virus infection among recyclable waste collectors in central Brazil

Marinho

Lopes

Teles

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…More partial HBV/D4 sequences have also been described (Andernach et al, 2009, Norder et al, 2004, Osiowy et al, 2011, Santos et al, 2010 mainly in the S gene. Phylogenetic analyses with all published D4 partial sequences confirmed that Martinican strains clearly belong to the HBV/D4 subgenotype but do not form a separate cluster (data not shown).…”

mentioning

confidence: 96%

African, Amerindian and European hepatitis B virus strains circulate on the Caribbean Island of Martinique

Brichler

Lagathu

Chekaraou

et al. 2013

Journal of General Virology

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Ten Hepatitis B virus (HBV) genotypes, as well as numerous subgenotypes, have been described in well-characterized ethnogeographical populations. Martinique has been at a crossroads between Africa, Europe, India and the Americas because of the slave trade (17th-19th centuries), followed by an important immigration of Indian and West African workers. In this work, we aimed to study the molecular epidemiology of HBV infection in Martinique according to this unique settlement pattern. To that end, blood samples from 86 consecutive HBV-infected patients from the main hospitals of the island, were retrospectively analysed. Direct sequencing of the pre-S1 or pre-C-C region or complete genome sequencing, followed by phylogenetic analyses were performed. HBV genotypes were: HBV/A1 (68.6 %), HBV/A2 (10.5 %), HBV/D, mainly HBV/D3 and HBV/D4 (8.1 %), HBV/F (3.5 %), and also HBV/E (2.3 %), two strains isolated from two West-African patients. Moreover, 74 % of the HBeAg-negative strains harboured classical pre-C-C mutations, and most HBV/A1 strains also containing specific mutations. Finally, various patterns of deletion mutants in pre-S and pre-C-C regions were found. In conclusion, our findings point to historical and migration-related issues in HBV-genotype distribution suggesting that HBV/A1, but not HBV/E, was imported from Africa during the slave trade, and further supporting the hypothesis that HBV/E has emerged recently in West Africa (,150 years). Potential origins of 'European' HBV/A2 and HBV/D3, 'Amerindian' HBV/F, and HBV/D4 strains are also discussed. Such HBV genetic diversity, beyond its epidemiological interest, may have a clinical impact on the natural history of HBV infection in Martinique.

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“…45,46 Genotype F has frequently been described in the Amazon, 17,26,[47][48][49] particularly among native populations. 4 Genotype D was found in an isolate from an individual who was not native to the community studied and is similar to genotypes found in the Mediterranean and East Africa.…”

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confidence: 99%

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAgpositive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil

Cited by 45 publications

References 66 publications

Epidemiology of hepatitis B virus infection among recyclable waste collectors in central Brazil

Epidemiology of hepatitis B virus infection among recyclable waste collectors in central Brazil

African, Amerindian and European hepatitis B virus strains circulate on the Caribbean Island of Martinique

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

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