Characterization of head and neck lesions with diffusion-weighted MR imaging and the apparent diffusion coefficient values

Shahat, Hazem Mohamed El; Fahmy, Hadeer Safwat; Gouhar, Ghada K.

doi:10.1016/j.ejrnm.2013.08.002

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cut off value of 1.15 ×10 -3 mm 2 /s of ADC could differentiate benign from malignant lymph nodes. [30] Our findings also correlate with study conducted by All these studies demonstrate that diffusion weighted imaging with ADC threshold value can differentiate the benign and malignant lymph nodes [3,4,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] . However our findings did not correlate with study conducted by Hun Kung Lim et al in which they concluded that mean ADC does not allow differentiating benign from metastatic cervical lymph nodes in patients with head and neck cancer and non-necrotic, small lymph nodes [46] .…”

Section: Diffusion Weighted Imaging and Adc Mapssupporting

confidence: 86%

Differentiation of benign and malignant cervical lymph nodes on MRI with special emphasis on DWI

Choure¹,

Khaladkar²,

Jain³

2019

Int. J. Radiol. Diagn. Imaging

View full text Add to dashboard Cite

Aim and objectives: Evaluation of cervical lymph nodes with MRI, utility of DWI in differentiation of benign and malignant cervical lymph nodes. Methods: Prospective study was carried out on 71 patients of cervical lymphadenopathy in Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune over a period of two years. Patients were evaluated with Siemens MAGNETOM Avanto 1.5 T MRI machine. Characteristics of cervical lymph nodes on T1WI, T2WI, STIR and Diffusion weighted images with ADC values were studied.Comparison was made with histopathological reports to study accuracy of MRI DWI in differentiating benign and malignant lymph nodes. Results: Out of the total 71 cases, 41 cases were of benign lymph nodes and 30 cases were of malignant lymph nodes. Characteristics of lymph nodes were studied on MRI. Malignant lymph nodes showed diffusion restriction with corresponding low ADC values. Mean ADC value of benign lymph nodes was 1.1×10 -3 mm 2 /s (±0.9 SD) and for malignant lymph nodes was 0.7×10 -3 mm 2 /s (±0.2 SD).The suggested ADC cut off value in our study for differentiating benign from malignant lymph nodes was to be 0.93×10 -3 mm 2 /s. Conclusion: Diffusion weighted imaging (DWI) is an important non-invasive diagnostic method for differentiation of benign and malignant cervical lymph nodes in case of head, neck cancers.

show abstract

Section: Diffusion Weighted Imaging and Adc Mapssupporting

confidence: 86%

Differentiation of benign and malignant cervical lymph nodes on MRI with special emphasis on DWI

Choure¹,

Khaladkar²,

Jain³

2019

Int. J. Radiol. Diagn. Imaging

View full text Add to dashboard Cite

show abstract

“…Many studies tried to evaluate the role of DW-MRI in head and neck masses with trials to put technical standardization, as results obtained depend on selection of b values. Image quality could be impeded due to different factors as magnetic field inhomogeneity and improper placement of receiver coils; this reflected on the interpretation of DWI in the head and neck masses [8].…”

Section: Introductionmentioning

confidence: 99%

Multiple b values of diffusion-weighted magnetic resonance imaging in evaluation of solid head and neck masses

Khadrah

Imam

2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: Differentiation between malignant and benign masses is essential for treatment planning and helps in improving the prognosis of malignant tumors; the aim of this work is to determine the role of diffusionweighted magnetic resonance imaging (DW-MRI) and the apparent diffusion coefficient (ADC) in the differentiation between benign and malignant solid head and neck masses by comparing diagnostic performance of low b values (0.50 and 400 s/mm 2) versus high b values (800 and 1000 s/mm 2) and comparing the result with histopathological finding. Results: The study included 60 patients (34 male and 26 female) with solid head and neck masses > 1 cm who referred to radiodiagnosis department for MRI evaluation. Multiple b values were used 50, 400, 800, and 1000 s/mm 2 (at least 2 b values). DWI and ADC value of all 60 patients were acquired. Mean ADC values of both malignant and benign masses were statistically measured and compared, and cut off value was determined. Solid head and neck masses in our study DWI with the use of high b value 800 and 1000 s/mm 2 were of higher significance (P value 0.001*). There was a significant difference in the mean ADC value between benign and malignant masses (P < 0.01); solid masses were divided into 2 categories: (a) malignant lesions 46.7% (n = 28) with mean ADC value (0.82 ± 0.19) × 10 −3 s/mm 2 and (b) benign lesions 53.3% (n = 32) with mean ADC value (2.05 ± 0.46) × 10 −3 s/mm 2) with ADC cutoff value of 1.0 × 10 −3 s/mm 2 and 94% sensitivity, 93% specificity, negative predictive value (NPV) = 94%, positive predictive value (PPV) 93%, and an accuracy of 93.5%. Conclusion: The DWI with ADC mapping were valuable as non-invasive tools in differentiating between benign and malignant solid head and neck masses. The use of high b value 800 and 1000 s/mm 2 was of higher significance (P value 0.001*) in differentiation between benign and malignant lesion than that with low b values 0, 50, and 400 s/mm 2 (0.01). The mean ADC values were significantly lower in malignant solid masses. Attention had to be paid to the choice of b values in MRI-DWI in the head and neck region.

show abstract

“…Multiple studies that were excluded from the present study for particular reasons also reported lower ADC values for head and neck lymphomas compared to head and neck cancers (25–34). Furthermore, a systematic review and meta-analysis on neck lymph nodes reported comprehensive results showing that neck lymph node lesions in lymphomas have lower ADC values compared to metastatic neck lymph node lesions (35).…”

Section: Discussionmentioning

confidence: 78%

Apparent diffusion coefficient for differentiation between extra-nodal lymphoma and squamous cell carcinoma in the head and neck: a systematic review and meta-analysis

Baba,

Kurokawa,

Kurokawa

et al. 2024

Acta Radiol

View full text Add to dashboard Cite

Background Radiological differentiation between extra-nodal lymphoma and squamous cell carcinoma in the head and neck is often difficult due to their similarities. Purpose To evaluate the diagnostic benefit of apparent diffusion coefficient (ADC) calculated from diffusion-weighted imaging (DWI) in differentiating the two. Material and Methods A systematic review was performed by searching the MEDLINE, Scopus, and Embase databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. Forest plots and the pooled mean difference of ADC values were calculated to describe the relationship between extra-nodal lymphoma and squamous cell carcinoma in the head and neck. Heterogeneity among studies was evaluated using the Cochrane Q test and I2 statistic. Results The review identified eight studies with 440 patients (441 lesions) eligible for meta-analysis. Among all studies, the mean ADC values of squamous cell carcinoma was 0.88 × 10–3mm2/s and that of lymphoma was 0.64 × 10–3mm2/s. In the meta-analysis, the ADC value of lymphoma was significantly lower than that of squamous cell carcinoma (pooled mean difference = 0.235, 95% confidence interval [CI] = 0.168–0.302, P <0.0001). The Cochrane Q test (chi-square = 55.7, P <0.0001) and I2 statistic (I2 = 87.4%, 95% CI = 77.4–93.0%) revealed significant heterogeneity. Conclusion This study highlights the value of quantitative assessment of ADC for objective and reliable differentiation between extra-nodal lymphoma and squamous cell carcinoma in the head and neck. Conclusions should be interpreted with caution due to heterogeneity in the study data.

show abstract

Characterization of head and neck lesions with diffusion-weighted MR imaging and the apparent diffusion coefficient values

Cited by 6 publications

References 25 publications

Differentiation of benign and malignant cervical lymph nodes on MRI with special emphasis on DWI

Differentiation of benign and malignant cervical lymph nodes on MRI with special emphasis on DWI

Multiple b values of diffusion-weighted magnetic resonance imaging in evaluation of solid head and neck masses

Apparent diffusion coefficient for differentiation between extra-nodal lymphoma and squamous cell carcinoma in the head and neck: a systematic review and meta-analysis

Contact Info

Product

Resources

About