Characterization of hap nanostructures doped with AgNp and the gamma radiation effects

Villaseñor-Cerón, Lesly Sabina; Rodríguez-Lugo, Ventura; Alatorre, Javier; Fernández-García, M. E.; Reyes-Valderrama, María Isabel; González-Martínez, P.R.; Anaya, Demetrio Mendoza

doi:10.1016/j.rinp.2019.102702

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…HAp can be synthesized by different routes, (i) dry methods: solid-state synthesis [8] and mechanochemical [9]; (ii) wet methods: conventional chemical precipitation, hydrolysis, sol-gel, hydrothermal, emulsion, and sonochemistry [10]; and (iii) high temperature processes: combustion and pyrolysis [11]. However, the remaining challenge consists in establishing an adequate synthesis method that allows obtaining a product with enhanced physicochemical characteristics and properties, i.e., with an exquisite crystallite and particle size control, and structure homogeneity, avoiding by-products and the appearance of new phases [12][13][14][15][16]. In this perspective, microwave synthesis is an alternative technique to provide autogenous thermal energy to the reaction.…”

Section: Introductionmentioning

confidence: 99%

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

et al. 2021

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Hydroxyapatite (HAp) is a natural hard tissue constituent widely used for bone and tooth replacement engineering. In the present work, synthetic HAp was obtained from calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) and ammonium phosphate dibasic (NH4)2HPO4 following an optimized microwave assisted hydrothermal method. The effect of pH was evaluated by the addition of ammonium hydroxide (NH4OH). Hence, different characterization techniques were used to determine its influence on the resulted HAp powders’ size, shape, and crystallinity. By Transmission Electron Microscopy (TEM), it was observed that the reaction pH environment modifies the morphology of HAp, and a shape evolution, from sub-hedral particles at pH = 7 to rod-like nanosized HAp at pH = 10, was confirmed. Using the X-ray Diffraction (XRD) technique, the characteristic diffraction peaks of the monoclinic phase were identified. Even if the performed Rietveld analysis indicated the presence of both phases (hexagonal and monoclinic), monoclinic HAp prevails in 95% with an average crystallite size of about 23 nm. The infrared spectra (FTIR) showed absorption bands at 3468 cm−1 and 630 cm−1 associated with OH− of hydroxyapatite, and bands at 584 cm−1, 960 cm−1, and 1090 cm−1 that correspond to the PO43− and CO32− characteristic groups. In summary, this work contributes to obtaining nanosized rod-like monoclinic HAp by a simple and soft method that has not been previously reported.

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Section: Introductionmentioning

confidence: 99%

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

et al. 2021

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“…This is because the pH is a supersaturation indicator since it influences the ions balance; by varying it, different OHconcentrations are generated, and as a consequence, the Ca 2+ , PO 4 3 , (HPO 4 ) 2ion concentrations are also modified. It should be mentioned that a high concentration of OHcan facilitate the precipitation during the synthesis of HAp [26,27].…”

Section: Introductionmentioning

confidence: 99%

“…As it will be shown, it was identified the presence of monoclinic HAp; that is very interesting because the synthesis was made at low temperature. For this reason, a reasonable explanation based on the pH effects on the final hydroxyapatite characteristics by hydrothermal method was included [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

The pH Effect on the Growth of Hexagonal and Monoclinic Hydroxyapatite Synthesized by the Hydrothermal Method

López-Ortiz

Mendoza-Anaya

Sánchez-Campos

et al. 2020

Journal of Nanomaterials

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Summary. In the present work, a study of H+ effects on the microstructure and morphology of hydroxyapatite synthesized by the hydrothermal method is reported. The synthesis was realized with pH values of 10, 9.6, 9, 8, and 7. To know the particle size distribution, growth habit, chemical composition, and crystalline phases present, SEM-EDS, XRD, AFM, and FTIR spectroscopy techniques were used and completed with Rietveld analysis. The obtained results showed an important effect of H+ on the morphological and crystallographic characteristics of the hydroxyapatite, demonstrating that the shape and nanoparticle size, as well as the number of crystalline phases, can change depending on the pH during the synthesis. It was observed that there is an increase in the formation of the monoclinic phase and a decrease of the hexagonal phase when the pH value diminishes from 9.6 to 7. The crystallite size also decreases from 46.69 to 19.56 nm. An explanation of the role of pH on the final characteristics of the hydroxyapatite was related to the amount of H+ and OH- ions, and it was included in this work.

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“…Esta metodología puede combinarse con la precipitación química o, ser asistida por microondas (Villaseñór-Cerón et al 2019;Sánchez-Campos et al 2020), llevando a cabo el tiempo de maduración a temperaturas superiores al punto de ebullición del agua y dentro de un autoclave o frasco a presión. A partir de las condiciones experimentales y uso de aditivos, la vía hidrotermal se utiliza para obtener morfologías tipo rodillo o varilla, promoviendo el crecimiento de la estructura en una dirección específica, y NMs híbridos con una amplia gama de aplicaciones (Ortiz et al 2017;Rodríguez-Lugo et al 2018;Mendoza-Anaya et al 2018;Villaseñor Cerón et al 2019 ilustra un protocolo experimental que emplea bromuro de cetiltrimetilamonio (CTAB) como plantilla, para la síntesis de nano-rodillos de Hap. La Hap obtenida por este método guarda su relación estequiométrica de 1.67 y presenta una alta cristalinidad.…”

Section: Liberación De Fármacosunclassified

Revisión de la Hidroxiapatita Nanoestructurada como Alternativa para Tratamiento de Cáncer

Rodríguez-Lugo

Salado-Leza

Ortiz

et al. 2020

ICBI

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La hidroxiapatita nanoestructurada (nano-Hap) surge como una potente herramienta biomimética para mejorar el desempeño de las terapias convencionales contra el cáncer. Su composición química, textura y capacidad de dopaje, así como su compatibilidad, estabilidad y actividad en sistemas biológicos la hacen una candidata excepcional para el desarrollo de vehículos para la entrega selectiva de fármacos antineoplásicos. La presente revisión va dirigida a estudiantes e investigadores del área de materiales avanzados, con la intensión de introducirlos en la importancia de explorar de manera interdisciplinaria las propiedades intrínsecas y adquiridas de los nanomateriales en beneficio de la sociedad, principalmente para ciencias de la salud. Con un propósito formativo, presentamos generalidades de la síntesis, caracterización y evaluación toxicológica in vitro de la nano-Hap para, finalmente discutir los avances más relevantes en el área del 2016 a la fecha. Concluimos incentivando a la comunidad al trabajo colaborativo interdisciplinar para innovar en Nanomedicina con materiales que permitan mejorar el desempeño de los protocolos oncológicos existentes.

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Characterization of hap nanostructures doped with AgNp and the gamma radiation effects

Cited by 10 publications

References 21 publications

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

The pH Effect on the Growth of Hexagonal and Monoclinic Hydroxyapatite Synthesized by the Hydrothermal Method

Revisión de la Hidroxiapatita Nanoestructurada como Alternativa para Tratamiento de Cáncer

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