Characterization of hantaviruses circulating in Central Brazil

Melo‐Silva, Carolina R.; Maranhão, Andréa Queiroz; Nagasse-Sugahara, Teresa Keico; Bisordi, Ivani; Suzuki, Akemi; Brigido, Marcelo M.

doi:10.1016/j.meegid.2008.11.008

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…However, in the DF, only the Andes clade, which includes the Araraquara and Paranoa genotypes, has been found so far (12) (13) . There are different clinical and epidemiological patterns related with the diversity of the etiological agent (14) .…”

Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus diseases are emerging human diseases caused by Hantavirus spp. of the Bunnyaviridae family. Hantavirus pulmonary syndrome (HPS) has been detected in the Federal District (DF) of Brazil since 2004. Among the 27 Brazilian Federal Units, DF has the highest fatality rate. More than 10 years have already passed since then, with confi rmation of cases caused by the Araraquara and Paranoa species. The reservoir is Necromys lasiurus. Methods: Local surveillance data of the confi rmed cases were analyzed, including age, sex, month and year of occurrence, clinical symptoms, syndromes and outcomes, and probable transmission place (PTP). The cases were mainly confi rmed by IgM detection with a capture enzyme immunoassay. The cases were classifi ed as autochthonous if PTPs were in the DF area. Results: From 2004 to 2013, in the DF, 126 cases of hantavirus were confi rmed, and the cumulative incidence was 5.0 per 100,000 inhabitants. The occurrence of cases was predominantly from April to August. At least 75% of the cases were autochthonous. Acute respiratory failure was reported in 47.5% of cases, and the fatality rate was 40%. Conclusions: In the DF, the cumulative incidence of HPS was one of the highest worldwide. A seasonal pattern of hantavirus disease in the dry season is clear. There was a high frequency of severe clinical signals and symptoms as well as a high fatality rate. For the near future, visitors and inhabitants of DF rural areas, particularly male adults, should receive continuous education about hantavirus transmission and prevention.

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Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…(3) The Araraquara clade includes all sequences named Araraquara Preferential host switching in Hantavirus and Paranoa. The former genotype was detected in HPS patients and in Necromys lasiurus specimens from southern and central Brazil (Johnson et al, 1999;Ramsden et al, 2009), whereas the latter was detected only in HPS cases from one locality in central Brazil (Melo-Silva et al, 2009). In our phylogenetic reconstruction, the Paranoa and Araraquara sequences from this locality (Federal District, Brazil) cluster together, suggesting that Paranoa is a synonym of Araraquara.…”

Section: Discussion Hantavirus Diversity In South Americamentioning

confidence: 99%

Preferential host switching and its relation with Hantavirus diversification in South America

Rivera

González‐Ittig

Gardenal

2015

Journal of General Virology

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In recent years, the notion of co-speciation between Hantavirus species and their hosts was discarded in favour of a more likely explanation: preferential host switching. However, the relative importance of this last process in shaping the evolutionary history of hantaviruses remains uncertain, given the present limited knowledge not only of virus-host relationships but also of the pathogen and reservoir phylogenies. In South America, more than 25 hantavirus genotypes were detected; several of them act as aetiological agents of hantavirus pulmonary syndrome (HPS). An understanding of the diversity of hantaviruses and of the processes underlying host switching is critical since human cases of HPS are almost exclusively the result of human-host interactions. In this study, we tested if preferential host switching is the main process driving hantavirus diversification in South America, by performing a co-phylogenetic analysis of the viruses and their primary hosts. We also suggest a new level of amino acid divergence to define virus species in the group. Our results indicate that preferential host switching would not be the main process driving virus diversification. The historical geographical proximity among rodent hosts emerges as an alternative hypothesis to be tested.

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“…This phenomenon may be due to differences of severity between infections caused by Brazilian lineages of hantavirus [1]. Phylogenetic data indicate that in the Central Plateau the main groups of hantavirus are very similar to ARAV [23]. Although ARAV strains are more frequently associated with higher virulence and severe manifestations, many infections caused by this virus are benign [1].…”

Section: Discussionmentioning

confidence: 99%

Hantavirus pulmonary syndrome in Brasilia periphery: a diagnostic challenge

Santos

Sá

Turra

et al. 2009

J Infect Dev Ctries

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Background: Hantavirus pulmonary syndrome (HPS) is an emerging rodent-borne disease in the American continent, characterized by acute respiratory distress and a high case-fatality ratio. The present work describes a case of HPS, with favorable outcome, whose initial features were mistaken for leptospirosis or other less severe acute infections. Methodology: The case of a 32-year-old male with an uneventful course of HPS is reported. He was inadvertently infected at work by exposure to a rodent-contaminated environment in Brasília, Federal District vicinity, during May 2008. Results and Conclusions: Fever, headache and myalgia after exposure to a rodent-contaminated environment raised clinical suspicion. Noncardiac pulmonary edema, hydrothorax, neutrophilia with band forms 26%, high hematocrit, thrombocytopenia, and elevated liver enzymes were observed. Leptospirosis and dengue were the main differential diagnoses because both pathogens are endemic in the area. Hantavirus IgM antibody-capture ELISA was positive, while tests for dengue, leptospirosis and yellow fever were negative. The prognosis for HPS is ominous and misdiagnoses may increase mortality. Better chances of survival depend on prompt intensive care support. Reports of moderate or less typical cases can raise the suspicion index among primary care and hospital-based physicians about this uncommon but severe condition that often affects previously healthy young individuals from developing countries, and subjects who interact with rodent-infested environments in North America. High awareness of HPS allowed successful management of the patient, even before establishing the diagnosis, by serological tests at the reference laboratory of the Ministry of Health. Clinical suspicion favored warning local health authorities about a new case of HPS.

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Characterization of hantaviruses circulating in Central Brazil

Cited by 7 publications

References 24 publications

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Preferential host switching and its relation with Hantavirus diversification in South America

Hantavirus pulmonary syndrome in Brasilia periphery: a diagnostic challenge

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