Characterization of Gut Microbiota Compositions along the Intestinal Tract in
            <i>CD163/pAPN</i>
            Double Knockout Piglets and Their Potential Roles in Iron Absorption

Zhang, Xiuling; Zhou, Yanrong; Xu, Song-Song; Xu, Si; Xiong, Yujian; Xu, Kui; Xu, Changjiang; Che, Jingjing; Huang, Lei; Liu, Zhiguo; Wang, Bingyuan; Mu, Yulian; Xiao, Shaobo; Li, Kui

doi:10.1128/spectrum.01906-22

Cited by 2 publications

(1 citation statement)

References 60 publications

(73 reference statements)

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“…Here we also saw that the relative abundance of Ruminococcaceae_UCG-014 increased in the CMH, suggesting that there was a close relationship between the intake of IONPs and Ruminococcaceae_UCG-014. Zhang et al [67] found that the abundance of Ruminococcaceae_UCG-014 in pigs was negatively 10 correlated with tissue iron levels, which is inconsistent with the present study; this may be due to the different study animals. Bilophila is a genus of lipopolysaccharide (LPS)-producing and mucosadamaging bacteria [68], Marvinbryantia is a characteristic bacteria in the colonic mucosal microbiota [69], and Bifidobacterium can competitively occupy the surface of the intestinal mucosa, preventing the invasion of pathogenic bacteria and reducing the absorption of LPS [70].…”

Section: Discussioncontrasting

confidence: 95%

Effects of food-grade iron(III) oxide nanoparticles on cecal digesta- and mucosa-associated microbiota and short-chain fatty acids in rats

SHI,

XIE,

et al. 2024

Bioscience of Microbiota, Food and Health

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Although iron(Ⅲ) oxide nanoparticles (IONPs) are widely used in diverse applications ranging from food to biomedicine, the effects of IONPs on different locations of gut microbiota and short-chain fatty acids (SCFAs) are unclear. So, a subacute repeated oral toxicity study on Sprague Dawley (SD) rats was performed, administering low (50 mg/kg•bw), medium (100 mg/kg•bw), and high (200 mg/kg•bw) doses of IONPs. In this study, we found that a high dose of IONPs increased animal weight, and 16S rRNA sequencing revealed that IONPs caused intestinal flora disorders in both the cecal digesta-and mucosa-associated microbiota. However, only high-dose IONP exposure changed the abundance and composition of the mucosa-associated microbiota. IONPs increased the relative abundances of Firmicutes, Ruminococcaceae_UCG-014, Ruminiclostridium_9, Romboutsia, and Bilophila and decreased the relative abundance of Bifidobacterium, and many of these microorganisms are associated with weight gain, obesity, inflammation, diabetes, and mucosal damage. Functional analysis showed that changes in the gut microbiota induced by a high dose of IONPs were mainly related to metabolism, infection, immune, and endocrine disease functions. IONPs significantly elevated the levels of valeric, isobutyric, and isovaleric acid, promoting the absorption of iron. This is the first description of intestinal microbiota dysbiosis in SD rats caused by IONPs, and the effects and mechanisms of action of IONPs on intestinal and host health need to be further studied and confirmed.

show abstract

Section: Discussioncontrasting

confidence: 95%

Effects of food-grade iron(III) oxide nanoparticles on cecal digesta- and mucosa-associated microbiota and short-chain fatty acids in rats

SHI,

XIE,

et al. 2024

Bioscience of Microbiota, Food and Health

View full text Add to dashboard Cite

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Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential

Liu,

Li,

et al. 2023

Biomedicine & Pharmacotherapy

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Characterization of Gut Microbiota Compositions along the Intestinal Tract in CD163/pAPN Double Knockout Piglets and Their Potential Roles in Iron Absorption

Abstract: Iron deficiency is a major risk factor for iron deficiency anemia, which is among the most common nutritional disorders in piglets. However, it remains unclear how the gut microbiota interacts with host iron absorption.

Cited by 2 publications

References 60 publications

Effects of food-grade iron(III) oxide nanoparticles on cecal digesta- and mucosa-associated microbiota and short-chain fatty acids in rats

Effects of food-grade iron(III) oxide nanoparticles on cecal digesta- and mucosa-associated microbiota and short-chain fatty acids in rats

Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential

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