Characterization of gut microbiome and metabolome in<i>Helicobacter pylori</i>patients in an underprivileged community in the United States

White, Brian; Sterrett, John D.; Grigoryan, Zoya; Lally, Lauren T.; Heinze, Jared D.; Alikhan, Hyder; Lowry, Christopher A.; Perez, Lark J.; DeSipio, Joshua; Phadtare, Sangita

doi:10.3748/wjg.v27.i33.5575

Cited by 16 publications

(12 citation statements)

References 82 publications

(63 reference statements)

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“…In contrast, H. pylori eradication treatment is effective in improving symptoms in patients with H. pylori -associated dyspepsia ( Tanaka et al, 2021 ). H. pylori infection has the ability to affect not only the microbiota in the gastrointestinal tract but also the microbial metabolism, which affects the occurrence and progression of FD through these pathways ( White et al, 2021 ).…”

Section: H Pylori Gastrointestinal Microbiota and Fdmentioning

confidence: 99%

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

Zhou¹,

Zeng

Zhang

et al. 2022

Front. Physiol.

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Functional dyspepsia is a clinically common functional gastrointestinal disorder with a high prevalence, high impact and high consumption of medical resources. The microbiota in the gastrointestinal tract is a large number of families and is one of the most complex microbial reservoirs in the human body. An increasing number of studies have confirmed the close association between dysbiosis of the gastrointestinal microbiota and the occurrence and progression of functional dyspepsia. Therefore, we reviewed the role of dysbiosis of the gastrointestinal microbiota, H. pylori infection and gastrointestinal microbiota metabolites in functional dyspepsia, focusing on the possible mechanisms by which dysbiosis of the gastrointestinal microbiota contributes to the pathogenesis of functional dyspepsia. Several studies have confirmed that dysbiosis of the gastrointestinal microbiota may cause the occurrence and progression of functional dyspepsia by disrupting the biological barrier of the intestinal mucosa, by disturbing the immune function of the intestinal mucosa, or by causing dysregulation of the microbial-gut-brain axis. Probiotics and antibiotics have also been chosen to treat functional dyspepsia in clinical studies and have shown some improvement in the clinical symptoms. However, more studies are needed to explore and confirm the relationship between dysbiosis of the gastrointestinal microbiota and the occurrence and progression of functional dyspepsia, and more clinical studies are needed to confirm the therapeutic efficacy of microbiota modulation for functional dyspepsia.

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Section: H Pylori Gastrointestinal Microbiota and Fdmentioning

confidence: 99%

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

Zhou¹,

Zeng

Zhang

et al. 2022

Front. Physiol.

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“…While cumulative antibiotic use-in particular fluoroquinolones-may alter the prevalence of antibiotic-resistant H. pylori, this relationship may also be mediated by mechanisms that are not yet fully elucidated. We observed that H. pylori infection is associated with significantly decreased fecal microbial diversity relative to controls over the age of 40 years [46]. Our results suggest that H. pylori may cause an alteration of the fecal microbiome that progresses with age.…”

Section: Agementioning

confidence: 54%

“…Overall, the relationship between antibiotic resistant H. pylori and PPIs remains to be fully elucidated. Given emerging concerns about PPI over-prescription and adverse effects of long-term use, including decreased distal gut microbial diversity observed in our recent analysis of H. pylori patients taking PPI prior to eradication therapy, this topic warrants further study [46,73].…”

Section: Proton Pump Inhibitors (Ppis) Gene Polymorphism and H Pylori...mentioning

confidence: 96%

Clinical Factors Implicated in Antibiotic Resistance in Helicobacter pylori Patients

et al. 2022

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Helicobacter pylori is a common gastric pathogen associated with multiple clinical syndromes, including cancer. Eradication rates of H. pylori remain suboptimal despite the progress made in the past few decades in improving treatment strategies. The low eradication rates are mainly driven by antibiotic resistance of H. pylori. Non-invasive molecular testing to identify patients with antibiotic-resistant H. pylori represents a promising therapeutic avenue, however this technology currently remains limited by availability, costs, and lack of robust validation. Moreover, there is insufficient evidence to demonstrate that resistance-testing-based treatment approaches are superior to appropriately designed empiric strategies. Consensus guidelines recommend use of proven locally effective regimens; however, eradication data are inconsistently generated in several regions of the world. In this review, we describe several clinical factors associated with increased rates of antibiotic resistant H. pylori, including history of previous antibiotic exposure, increasing age, female gender, ethnicity/race, extent of alcohol use, and non-ulcer dyspepsia. Assessment of these factors may aid the clinician in choosing the most appropriate empiric treatment strategy for each patient. Future study should aim to identify locally effective therapies and further explore the clinical factors associated with antibiotic resistance.

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“…HP-associated dysbiosis of the gastric flora is of particular importance in research because studies have shown increased relative abundance of specific taxa in patients who develop premalignant lesions and GC (Aviles-Jimenez et al, 2014). More recently, an exploratory study showed a significant relationship between the gut microbiome and metabolome datasets by comparing HP+ and HP− patients (White et al, 2021). The results of a study on the intragastric microenvironment of gastric cancer patients showed that the frequency and abundance of HP were significantly lower in the cancer group than in the noncancer group.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic and Metabolomic Profiling in Helicobacter pylori–Induced Gastric Cancer Identified Prognosis- and Immunotherapy-Relevant Gene Signatures

Liu

Zhu

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Background: Chronic Helicobacter pylori (HP) infection is considered the major cause of non-cardia gastric cancer (GC). However, how HP infection influences the metabolism and further regulates the progression of GC remains unknown.Methods: We comprehensively evaluated the metabolic pattern of HP-positive (HP+) GC samples using transcriptomic data and correlated these patterns with tumor microenvironment (TME)–infiltrating characteristics. The metabolic score was constructed to quantify metabolic patterns of individual tumors using principal component analysis (PCA) algorithms. The expression alterations of key metabolism-related genes (MRGs) and downstream metabolites were validated by PCR and untargeted metabolomics analysis.Results: Two distinct metabolic patterns and differential metabolic scores were identified in HP+ GC, which had various biological pathways in common and were associated with clinical outcomes. TME-infiltrating profiles under both patterns were highly consistent with the immunophenotype. Furthermore, the analysis indicated that a low metabolic score was correlated with an increased EMT subtype, immunosuppression status, and worse survival. Importantly, we identified that the expression of five MRGs, GSS, GMPPA, OGDH, SGPP2, and PIK3CA, was remarkably correlated with HP infection, patient survival, and therapy response. Furthermore, the carbohydrate metabolism and citric acid may be downstream regulators of the function of metabolic genes in HP-induced GC.Conclusion: Our findings suggest that there is cross talk between metabolism and immune promotion during HP infection. MRG-specific transcriptional alterations may serve as predictive biomarkers of survival outcomes and potential targets for treatment of patients with HP-induced GC.

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Characterization of gut microbiome and metabolome inHelicobacter pyloripatients in an underprivileged community in the United States

Cited by 16 publications

References 82 publications

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

Clinical Factors Implicated in Antibiotic Resistance in Helicobacter pylori Patients

Transcriptomic and Metabolomic Profiling in Helicobacter pylori–Induced Gastric Cancer Identified Prognosis- and Immunotherapy-Relevant Gene Signatures

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