Characterization of Glycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis

Gaye, Maissa M.; Ward, Christina M.; Piasecki, Andrew; Stahl, Vanessa L.; Karagianni, Aikaterini; Costello, Catherine E.; Ravid, Katya

doi:10.1016/j.mcpro.2022.100213

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2022

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“…In a recent study, β1 and α2 integrins were isolated from megakaryocytes of Vav1-hJAK2 V617F mice and control mice. Glycosylation of both types of integrins affected Janus kinase-2 activity, which induced myelofibrosis in mice ( Gaye et al, 2022 ). In addition, glycosylation of type-IV collagen regulates binding of α2β1 and α3β1 integrin in melanocytes ( Stawikowski et al, 2014 ), and remodels the ECM ( Jürgensen et al, 2011 ) which, in turn, improves muscle tenderness.…”

Section: Resultsmentioning

confidence: 99%