Characterization of Ginsenosides from the Root of Panax ginseng by Integrating Untargeted Metabolites Using UPLC-Triple TOF-MS

Sun, Yizheng; Fu, Xiaojie; Qu, Ying; Chen, Lihua; Liu, Xiaoyan; He, Zichao; Xu, Jing; Jiao, Yang; Ma, Wen; Li, Jun; Guo, Qingmei; Zhang, You-Bo

doi:10.3390/molecules28052068

Cited by 4 publications

(1 citation statement)

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“…When it comes to the overall composition of ginsenosides, maximum diversity was observed at a 40 • C extraction temperature, and higher contents were detected when extracted for higher temperature conditions. This highlights the influence of cultivation methods on ginsenoside composition, especially for elicitation [41]. Among PPT-type ginsenoside (Figure 1C,F), both aerial and media supplementation treatment showed higher content of ginsenoside Re in the control treatment, in which there was no significant impact of the sodium silicate treatment on PPT-type ginsenosides, suggesting that sodium silicate affects mostly pathways linked to PPD type ginsenoside bioconversion.…”

Section: Impact Of Ir Treatment On Ginsenosides Content and Extractio...mentioning

confidence: 88%

Impact of Sodium Silicate Supplemented, IR-Treated Panax Ginseng on Extraction Optimization for Enhanced Anti-Tyrosinase and Antioxidant Activity: A Response Surface Methodology (RSM) Approach

Kabadayı,

Sadiq,

Hamayun

et al. 2023

Antioxidants

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Ginseng has long been widely used for its therapeutic potential. In our current study, we investigated the impact of abiotic stress induced by infrared (IR) radiations and sodium silicate on the upregulation of antioxidant and anti-tyrosinase levels, as well as the total phenolic and total flavonoid contents of the Korean ginseng (Panax ginseng C.A. Meyer) variety Yeonpoong. The RSM-based design was used to optimize ultrasonic-assisted extraction time (1–3 h) and temperature (40–60 °C) for better anti-tyrosinase activity and improved antioxidant potential. The optimal extraction results were obtained with a one-hour extraction time, at a temperature of 40 °C, and with a 1.0 mM sodium silicate treatment. We recorded maximum anti-tyrosinase (53.69%) and antioxidant (40.39%) activities when RSM conditions were kept at 875.2 mg GAE/100 g TPC, and 3219.58 mg catechin/100 g. When 1.0 mM sodium silicate was added to the media and extracted at 40 °C for 1 h, the highest total ginsenoside content (368.09 mg/g) was recorded, with variations in individual ginsenosides. Ginsenosides Rb1, Rd, and F2 were significantly affected by extraction temperature, while Rb2 and Rc were influenced by the sodium silicate concentration. Moreover, ginsenoside F2 increased with the sodium silicate treatment, while the Rg3-S content decreased. Interestingly, higher temperatures favored greater ginsenoside diversity while sodium silicate impacted PPD-type ginsenosides. It was observed that the actual experimental values closely matched the predicted values, and this agreement was statistically significant at a 95% confidence level. Our findings suggest that the application of IR irradiation in hydroponic systems can help to improve the quality of ginseng sprouts when supplemented with sodium silicate in hydroponic media. Optimized extraction conditions using ultrasonication can be helpful in improving antioxidant and anti-tyrosinase activity.

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Section: Impact Of Ir Treatment On Ginsenosides Content and Extractio...mentioning

confidence: 88%