Characterization of fully functional spray-on antibody thin films

Figueroa, Jhon; Magaña, Sonia; Lim, Daniel V.; Schlaf, R.

doi:10.1016/j.apsusc.2013.12.040

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…This allows for depositing oxide layers and is thus especially useful in OPV. Further variants of spray-based coating, such as rapid expansion of supercritical solutions (RESS) [113][114][115][116], jet nebulizer technique [117,118], thermal spraying [119,120], or flame and plasma spraying [121][122][123] as well as applications in biotechnology [124][125][126][127][128][129][130] will not be discussed in this review, and the reader is referred to the corresponding references.…”

Section: Introductionmentioning

confidence: 99%

A deep look into the spray coating process in real-time—the crucial role of x-rays

Roth

2016

J. Phys.: Condens. Matter

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Tailoring functional thin films and coating by rapid solvent-based processes is the basis for the fabrication of large scale high-end applications in nanotechnology. Due to solvent loss of the solution or dispersion inherent in the installation of functional thin films and multilayers the spraying and drying processes are strongly governed by non-equilibrium kinetics, often passing through transient states, until the final structure is installed. Therefore, the challenge is to observe the structural build-up during these coating processes in a spatially and time-resolved manner on multiple time and length scales, from the nanostructure to macroscopic length scales. During installation, the interaction of solid-fluid interfaces and between the different layers, the flow and evaporation themselves determine the structure of the coating. Advanced x-ray scattering methods open a powerful pathway for observing the involved processes in situ, from the spray to the coating, and allow for gaining deep insight in the nanostructuring processes. This review first provides an overview over these rapidly evolving methods, with main focus on functional coatings, organic photovoltaics and organic electronics. Secondly the role and decisive advantage of x-rays is outlined. Thirdly, focusing on spray deposition as a rapidly emerging method, recent advances in investigations of spray deposition of functional materials and devices via advanced x-ray scattering methods are presented.

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Section: Introductionmentioning

confidence: 99%

A deep look into the spray coating process in real-time—the crucial role of x-rays

Roth

2016

J. Phys.: Condens. Matter

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“…Methods were primarily initially developed to simply measure the amount of protein adsorbed to a surface, their competitive nature, and Vroman effects leading to the displacement of one adsorbed protein with another using techniques such as radiolabeling [16,17], surface plasmon resonance spectroscopy (SPR) [18], quartz crystal microbalance [17], and Fourier transform infrared (FTIR) spectroscopy [19,20]. Subsequently, more sophisticated experimental methods have been developed to obtain structural information regarding a protein's adsorbed orientation and conformation.…”

Section: Introductionmentioning

confidence: 99%

Perspectives on the simulation of protein–surface interactions using empirical force field methods

Latour

2014

Colloids and Surfaces B: Biointerfaces

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Protein–surface interactions are of fundamental importance for a broad range of applications in the fields of biomaterials and biotechnology. Present experimental methods are limited in their ability to provide a comprehensive depiction of these interactions at the atomistic level. In contrast, empirical force field based simulation methods inherently provide the ability to predict and visualize protein–surface interactions with full atomistic detail. These methods, however, must be carefully developed, validated, and properly applied before confidence can be placed in results from the simulations. In this perspectives paper, I provide an overview of the critical aspects that I consider being of greatest importance for the development of these methods, with a focus on the research that my combined experimental and molecular simulation groups have conducted over the past decade to address these issues. These critical issues include the tuning of interfacial force field parameters to accurately represent the thermodynamics of interfacial behavior, adequate sampling of these types of complex molecular systems to generate results that can be comparable with experimental data, and the generation of experimental data that can be used for simulation results evaluation and validation.

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Ellipsometric biosensors

Çağlayan¹

2023

Fundamentals of Sensor Technology

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Characterization of fully functional spray-on antibody thin films

Cited by 3 publications

References 61 publications

A deep look into the spray coating process in real-time—the crucial role of x-rays

A deep look into the spray coating process in real-time—the crucial role of x-rays

Perspectives on the simulation of protein–surface interactions using empirical force field methods

Ellipsometric biosensors

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