Characterization of fowl adenoviruses isolated between 2007 and 2014 in China

Changjing, Li; Li, Haiying; Wang, Dongdong; Wang, Jingjing; Wang, Youming; Wang, Shouchun; Li, Jida; Liu, Ping; Wang, Jianlin; Xu, Sihong; Cui, Shangjin; Zhang, Yi; Yin, Ye

doi:10.1016/j.vetmic.2016.11.005

Cited by 62 publications

(60 citation statements)

References 20 publications

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“…From this group, AdVs have been reported only from ostriches albeit not from their native distribution area but from commercial farms in Europe and China. Therefore, these results should be handled with precaution all the more so since the isolation was performed on primary chicken cells, and the recovered AdVs were identical with earlier described fowl AdV (FAdV) types . No direct PCR detection of AdVs has been reported ever from rhea or cassowary, thus we still cannot be sure if any such ancient avian AdVs exist at all, or how much they would differ from the known members of the genus Aviadenovirus .…”

Section: Advs In Birds (Aviadenovirus Atadenovirus Siadenovirus)mentioning

confidence: 80%

Adenoviruses across the animal kingdom: a walk in the zoo

2019

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Adenoviruses (AdVs) infect representatives of numerous species from almost every major vertebrate class, albeit their incidence shows great variability. AdVs infecting birds, reptiles, and bats are the most common and diverse, whereas only one AdV has been so far isolated both from fish and amphibians. The family Adenoviridae is divided into five genera, each corresponding to an independent evolutionary lineage that supposedly coevolved with its respective vertebrate hosts. Members of genera Mastadenovirus and Aviadenovirus seem to infect exclusively mammals and birds, respectively. The genus Ichtadenovirus includes the single known AdV from fish. The majority of AdVs in the genus Atadenovirus originated from squamate reptiles (lizards and snakes), but also certain mammalian and avian AdVs are classified within this genus. The genus Siadenovirus contains the only AdV isolated from frog, along with numerous avian AdVs. In turtles, members of a sixth AdV lineage have been discovered, pending official recognition as an independent genus. The most likely scenario for AdV evolution includes long‐term cospeciation with the hosts, as well as occasional switches between closely or, rarely, more distantly related hosts.

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Section: Advs In Birds (Aviadenovirus Atadenovirus Siadenovirus)mentioning

confidence: 80%

Adenoviruses across the animal kingdom: a walk in the zoo

2019

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“…In a similar way to the majority of more recent FAdV screenings studies (Changjing et al., ; De la Torre et al., ; Zhang et al., ), we have applied molecular typing based on the hexon loop‐1 for classification of the detected FAdV strains, replacing the traditional methods of serological cross‐neutralization assays and restriction fragment length polymorphism (Hess, ). Although these tests have served as the basis for typing of isolates, these methods of characterization are costly, require reference sera and are sometimes unable to differentiate between serotypes (Changjing et al., ; Hess, ). Using pairwise comparison, the percentage relatedness between the reference strains and the strains detected in this study showed strong support for the serotypes inferred.…”

Section: Discussionmentioning

confidence: 99%

Identification of four serotypes of fowl adenovirus in clinically affected commercial poultry co‐infected with chicken infectious anaemia virus in Trinidad and Tobago

Jordan

Blake

Bisnath³

et al. 2019

Transbound Emerg Dis

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Summary Fowl adenovirus (FAdV), which causes the high‐impact diseases such as inclusion body hepatitis and hepatitis‐hydropericardium syndrome, is of major concern to the poultry industry internationally. This study was carried out in direct response to mortality rates of up to 75% in commercial broiler flocks in Trinidad, West Indies. Symptoms in 3‐ to 8‐week‐old broilers and 13‐ to 18‐week‐old pullets pointed to infection with an immunosuppressive viral pathogen. The objectives of the study were to determine whether the infectious agent FAdV, along with other viral pathogens, was responsible for the clinical disease, and to obtain information on the serotypes of FAdV that were infecting the birds. Tissue samples from clinically affected birds from eight different farms were tested for chicken infectious anaemia virus (CIAV) and infectious bursal disease virus (IBDV) by real‐time reverse transcription polymerase chain reaction (PCR) and for FAdV by conventional PCR. The birds tested positive for FAdV and CIAV, but negative for IBDV. The gene corresponding to the L1 loop of the hexon protein for FAdV was amplified and sequenced. Phylogenetic analysis of seven FAdV strains inferred that four serotypes were likely to be circulating in the chickens. Well supported genetic relatedness was observed for serotype 8a (97.8%), 8b (97.8%), 9 (95.8%) and 11 (98.8%–99.5%). This is the first published report from Trinidad and Tobago on the presence and circulation of pathogenic FAdV strains, in combination with CIAV, in poultry. The data demonstrate a possible need for the introduction of serotype‐specific vaccines against FAdV, as well as vaccines against CIAV, in broilers in the region and emphasize the importance of maintaining high levels of biosecurity on farms to prevent the spread of these potentially devastating viruses between farms.

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“…The FAdV-4 strain was isolated and characterized as a novel genotype [ 24 , 26 ]. Although many studies have been conducted on inactivated or recombinant subunit vaccines consisting of several serotypes of FAdVs against the conventional FAdV-4 strains [ 32 , 33 , 34 , 35 , 36 , 37 ], no vaccine has been developed and evaluated for the HPS associated with the novel hypervirulent FAdV-4 [ 26 , 38 ]. In this study, an inactivated novel genotype FAdV-4 vaccine formulated with oil-emulsion was developed, and the immune responses and protective efficacy were evaluated by challenging SPF chickens with a lethal dose of the novel hypervirulent FAdV-4.…”

Section: Discussionmentioning

confidence: 99%

An Inactivated Novel Genotype Fowl Adenovirus 4 Protects Chickens against the Hydropericardium Syndrome That Recently Emerged in China

Pan

Yang

Gao

et al. 2017

Viruses

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Since 2015, China has experienced outbreaks of severe hydropericardium syndrome (HPS), associated with a novel genotype and hypervirulent fowl adenovirus serotype 4 (FAdV-4) infection, with a prevalence in various provinces of the country. This has resulted in huge economic losses in the poultry industry. The novel FAdV-4 showed new genome characters, such as the natural deletion of open reading frame (ORF) 19 and ORF 27 (1966 bp), and high pathogenicity toward chickens. These are coupled with severe hydropericardium, inclusion body hepatitis, and mortality rates ranging from 30% to 90%. Although several inactivated and subunit vaccines against the traditional FAdV-4 have been developed, no commercial vaccine against the emerged disease caused by the novel strain has been available until now. The potential risks of infection with this novel hypervirulent FAdV-4 urgently require an effective vaccine. Thus, an inactivated oil-emulsion FAdV-4 vaccine formulated with the novel genotype virus was developed in this study. The vaccine provided a high level of antibody, preferential T helper 2 (Th2) (interleukin-4 secretion) not Th1 (interferon-γ secretion) response, and full protection against a lethal dose of the novel hypervirulent FAdV-4. Therefore, the novel genotype FAdV-4 vaccine is proposed as an attractive candidate to prevent and reduce the spread of HPS in the poultry industry of China.

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Characterization of fowl adenoviruses isolated between 2007 and 2014 in China

Cited by 62 publications

References 20 publications

Adenoviruses across the animal kingdom: a walk in the zoo

Adenoviruses across the animal kingdom: a walk in the zoo

Identification of four serotypes of fowl adenovirus in clinically affected commercial poultry co‐infected with chicken infectious anaemia virus in Trinidad and Tobago

An Inactivated Novel Genotype Fowl Adenovirus 4 Protects Chickens against the Hydropericardium Syndrome That Recently Emerged in China

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