Characterization of folate-chitosan-DNA nanoparticles for gene therapy

Mansouri, Sania; Yan, Cheng; Winnik, Françoise M.; Shi, Qin; Lavigne, Patrick; Benderdour, Mohamed; Beaumont, Éric; Fernandes, Julio C.

doi:10.1016/j.biomaterials.2005.09.020

Cited by 368 publications

(218 citation statements)

References 24 publications

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“…Preparation of chitosan-DNA nanoparticles (CS/pDNA) [28] Described the method of CS/DNA formation as follow: Two types of CS, each of a different molecular weight, were dissolved separately in 25 mM acetic acid, which was then adjusted to pH 5.5 at a final concentration of 1% (stock solution). The stock solution was then diluted with distilled water to form different concentrations of CS solution (0.01, 0.02, 0.04 and 0.08%).…”

Section: 62mentioning

confidence: 99%

Transformation of Thionin Genes Using Chitosan Nanoparticle into Potato Plant to Be Resistant to Fungal Infection

Abdel-Razik¹,

Hammad²,

Tawfik³

2017

IOSR JBB

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Section: 62mentioning

confidence: 99%

Transformation of Thionin Genes Using Chitosan Nanoparticle into Potato Plant to Be Resistant to Fungal Infection

Abdel-Razik¹,

Hammad²,

Tawfik³

2017

IOSR JBB

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“…Folic acid could be easily absorbed by cells, promoting the targeting and internalization of drug. Mansouri et al 58 used folic acid to modify chitosan for improving gene transfection efficiency. They studied systematically the characteristics of folic acid for gene treatment, finding that folic acid-modified chitosan nanoparticles had low cell toxicity and could condense DNA effectively with ideal size and zeta potential.…”

mentioning

confidence: 99%

Recent advances of chitosan nanoparticles as drug carriers

Zeng¹

2011

IJN

253

124

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Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.

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“…Many research studies have been conducted for enhancement of transfection efficiency, such as pHsensitive modification , Jones, et al, 2003, Kim, et al, 2003, Wong, et al, 2006, temperature-sensitive modification , Dang, et al, 2006, Sun, et al, 2005, specific target ligand modification (Hashimoto, et al, 2006, Mansouri, et al, 2006, Wu & Wu, 1998 and so on. Among the chemical modifications of chitosan, PEI grafted chitosan showed some benefit due to high transfection efficiency.…”

Section: Cyclodextrinmentioning

confidence: 99%