Characterization of Focal Liver Lesions with Contrast-specific US Modes and a Sulfur Hexafluoride–filled Microbubble Contrast Agent: Diagnostic Performance and Confidence

Quaia, Emilio; Calliada, Fabrizio; Bertolotto, Michele; Rossi, Sandro; Garioni, Lorena; Rosa, Laura; Mucelli, Roberto Pozzi

doi:10.1148/radiol.2322031401

Cited by 444 publications

(466 citation statements)

References 31 publications

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“…Ricci et al [19] emphasized homogeneous and centripetal enhancement during artery phase was showed in almost all. In accordance with previous studies [19][20][21] , HCA lesions had some typical features, including early, homogeneous, centripetal, and strong enhancement in the arterial phase and the lack of a portal vein supply. According to a study [22] , a number of HCAs demonstrated persistent enhancement.…”

Section: Discussionsupporting

confidence: 91%

Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

Kumagawa¹,

Matsumoto²,

Watanabe³

et al. 2016

WJH

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Section: Discussionsupporting

confidence: 91%

Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

Kumagawa¹,

Matsumoto²,

Watanabe³

et al. 2016

WJH

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“…In addition, SonoVue ® is a purely intravascular contrast agent which makes it ideal for the evaluation of perfusion [12] . Insonated at low acoustic power, SonoVue ® , whose nonlinear harmonic response is high [13] , provides continuous realtime ultrasonographic (US) imaging without destroying the microbubbles [14] . Before any US exam, the contrast agent was reconstituted by introducing 5 mL of 0.9% sodium chloride into the vial, containing a pyrogen-free lyophilized product, followed by manual shaking for at least 20 s. One experiment involved several injections of SonoVue ® .…”

Section: Contrast Agentsmentioning

confidence: 99%

Estimation of intra-operator variability in perfusion parameter measurements using DCE-US

Gauthier¹

2011

WJR

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AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography (DCE-US), following bolus injections of SonoVue ® . METHODS:The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank. In the in vivo experiments, B16F10 melanoma cells were xenografted to five nude mice. Both in vitro and in vivo , images were acquired following bolus injections of the ultrasound contrast agent SonoVue ® (Bracco, Milan, Italy) and using a Toshiba Aplio ® ultrasound scanner connected to a 2.9-5.8 MHz linear transducer (PZT, PLT 604AT probe) (Toshiba, Japan) allowing harmonic imaging ("Vascular Recognition Imaging") involving linear raw data. A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute, Villejuif, France and used to evaluate seven perfusion parameters from time-intensity curves. Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation (CV). RESULTS:In vitro , different volumes of SonoVue ® were tested with the three phantoms: intra-operator variability was found to range from 2.33% to 23.72%.In vivo , experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%. In addition, the area under the curve (AUC) and the area under the wash-out (AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%. CONCLUSION:AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values.

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“…Contrast-enhanced ultrasound has meanwhile been evaluated for numerous organs and has been proven to have a clear role in the detection and differential diagnosis of liver lesions [7][8][9][10][11][12][13][14][15] . For this, low-MI imaging is the technique of choice since it allows the liver to be scanned in the usual way.…”

Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Contrast-enhanced ultrasound for examining tumor biology

Delorme

Krix²

2006

Cancer Imaging

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This paper reviews the potential of ultrasound for assessing the viability and biological behavior of tumors. Unlike color Doppler sonography, modern techniques for contrast-enhanced ultrasound permit the measurement of tissue perfusion irrespective of vessel size or flow velocity. Perfusion can also be assessed quantitatively, using replenishment kinetics or derivates thereof. The perfusion of tumors is a surrogate parameter of their viability and may mirror their response to therapy. Furthermore, the degree of vascularity in a tumor may express its aggressiveness and help to predict its response to treatment. In animal models, a decrease in blood flow has been shown to precede a shrinkage of tumors treated with anti-angiogenic compounds. In liver metastases, arterial and portal blood supply can be assessed separately, and a response to stereotactic radiotherapy was found to go along with a decrease in arterial perfusion. Moreover, a relatively high arterial perfusion of liver metastases may predict a response to chemotherapy. Contrastenhanced ultrasound may be a potent tool for assessing the effects of anti-angiogenic treatment in patients.

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Characterization of Focal Liver Lesions with Contrast-specific US Modes and a Sulfur Hexafluoride–filled Microbubble Contrast Agent: Diagnostic Performance and Confidence

Abstract: The use of contrast-specific modes with a sulfur hexafluoride contrast agent led to improved characterization of solid focal liver lesions.

Cited by 444 publications

References 31 publications

Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

Estimation of intra-operator variability in perfusion parameter measurements using DCE-US

Contrast-enhanced ultrasound for examining tumor biology

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