Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics

Abstract

The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles' size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle's ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets.

Rational PCR Reactor Design in Microfluidics

“…Thus, following the grid independence test, a total of 170,000 structured elements were used to discretize the geometry. The iterative method of GMRES with a convergence criterion of 0.001 was used to obtain solutions [39][40][41].…”