Characterization of Fibrous Polymer Silver/Cobalt Nanocomposite with Enhanced Bactericide Activity

Alonso, Amanda; Muñoz-Berbel, Xavier; Vigués, Núria; Macanás, Jorge; Muñoz, Marı́a; Mas, Jordi; Muraviev, Dmitri

doi:10.1021/la203239d

Cited by 36 publications

(24 citation statements)

References 29 publications

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“…Only for the case of Cd we did not observe the phenotype. Previously, different reports have used transition metals (primarily in nanoparticle or polymeric systems) in combination with silver to take advantage of its inhibitory effects; such is the case of Cu 55 , Zn 56 and Co 57 .…”

Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza-Cervantes

Chávez‐Reyes²,

Castillo

et al. 2017

Sci Rep

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Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E. coli and B. subtilis. We find that most combinatorial treatments exhibit synergistic antimicrobial effects at low/ non-toxic concentrations to human keratinocyte cells, blast and melanoma rat cell lines. Moreover, we show that silver/(Cu, Ni, and Zn) increase prokaryotic cell permeability at sub-inhibitory concentrations, demonstrating this to be a possible mechanism of the synergistic behavior. Together, these results suggest that these combinatorial treatments will play an important role in the future development of antimicrobial agents and treatments against infections. In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.

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Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Garza-Cervantes

Chávez‐Reyes²,

Castillo

et al. 2017

Sci Rep

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“…carboxylic resins and fibres) in which IMS was successfully applied for the preparation of MNPs. [34,67] IMS has never been used before for the surface modification of 0D supports as NDs. Even though; as it is based on the ion exchange functionality of the support; the IMS of CdSQDs on NDs procedure proposed is described by equations (3) and (4).…”

Section: Intermatrix Synthesis Cds-qds In Nanodiamonds (Cds-qds@nds)mentioning

confidence: 99%

Intermatrix Synthesis as a rapid, inexpensive and reproducible methodology for the in situ functionalization of nanostructured surfaces with quantum dots

Bastos-Arrieta

Muñoz

Stenbock-Fermor

et al. 2016

Applied Surface Science

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Multiwall Carbon Nanotubes (MWCNTs) and Nanodiamonds (NDs). The synthetic route takes advantage of the ion exchange functionality of the reactive surfaces for the loading of the QDs precursor and consequent QDs appearance by precipitation. The benefits of such modified nanomaterials were studied using CdS-QDs@MWCNTs hybrid-nanomaterials.CdS-QDs@MWCNTs has been used as conducting filler for the preparation of electrochemical nanocomposite sensors, which present electrocatalytic properties. Finally,

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“…Following this strategy, the expected biological effects would arise from the release of the bio-active metallic salt into the surrounding media. It hasis indeed been established that some metallic salts and/or organometallic complexes may have biological effects including bactericidal 21,22,23 (e.g. Ag, Co, Cu) or anti-cancer actions 24,25 (e.g.…”

Section: Introductionmentioning

confidence: 99%

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

et al. 2015

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(Word Style "BD_Abstract").Three novel silver-based Metal Organic Frameworks materials which were synthesized from either 3-phosphono or 4-phosphonobenzoic acid and silver nitrate are reported. The novel hybrids were synthesized under hydrothermal conditions; the pH of the reaction media was controlled by adding different quantities of urea thereby producing different topologies.Compound 1 (Ag3(4-PO3-C6H4-COO)), synthesised in presence of urea, exhibits a compact 3D structure in which both phosphonic acid and carboxylic acid functional groups are linked to the silver-based inorganic network. Compound 2 (Ag(4-PO3H-C6H4-COOH)), which was synthesized at lower pH (without urea), has a layered structure in which only the phosphonic acid functional groups from 4-phosphonobenzoic acid moieties are linked to the silver inorganic network; the carboxylic acid groups being engaged in hydrogen bonds. Finally, material 3 (Ag(3-PO3H-C6H4-COOH)) was synthesised from 3-phosphonobenzoic acid and silver nitrate without urea. This material 3 features a layered structure exhibiting carboxylic acid functional groups linked via hydrogen bonds in the interlayer space. After the full characterization of these materials (single X-ray structure, IR, TGA), their ability to release silver salts in aqueous environment was measured. Silver release, determined in aqueous solution by cathodic stripping voltammetry, shows that the silver release capacity of these materials is dependent on the topology of the hybrids. The more compact structure 1 is extremely stable in water with only trace levels of silver ions being detected. On the other hand, compounds 2 and 3, in which only the phosphonic acid functional groups were bonded to the inorganic network, released larger quantities of silver ions into aqueous solution. These results which were compared with the silver release of the previously described compound 4 (Ag6(3-PO3-C6H4-COO)2). The results clearly show that the release capacity of silver-based metal organic framework can be tuned by 3 modifying their topology which, in the present study, is governed by the regio-isomer of the organic precursor and the synthetic conditions under which the hybrids are prepared.4

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Characterization of Fibrous Polymer Silver/Cobalt Nanocomposite with Enhanced Bactericide Activity

Cited by 36 publications

References 29 publications

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Synergistic Antimicrobial Effects of Silver/Transition-metal Combinatorial Treatments

Intermatrix Synthesis as a rapid, inexpensive and reproducible methodology for the in situ functionalization of nanostructured surfaces with quantum dots

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

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