Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains

Gassen, Koen van; Hessel, Ellen V.S.; Ramakers, G.J.A.; Notenboom, Robbert G E; Wolterink-Donselaar, Inge G.; Brakkee, Jan H.; Godschalk, Thea C.; Qiao, Xiaomu; Spruijt, Berry M.; Nieuwenhuizen, Onno van; Graan, P.N.E. de

doi:10.1111/j.1601-183x.2008.00393.x

Cited by 43 publications

(63 citation statements)

References 34 publications

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“…In general, transponders measure about 2 mm diameter and 12-14 mm long and their use is not applied in animals younger than 8 -10 pnd or weighing less than 5 g (see example 19 ). Recently, a smaller sized microchip has been launched by Lutronic International (http://www.lutronic.eu/) as an identification method applicable to mice a few days after birth (http://www.rfcafe.com/miscellany/ press_releases/2007/lutronic_intl_6-11-2007.htm).…”

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Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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The use of group-housed rodents in many fields of biomedical research imposes a need to identify individuals in a cage. Few studies have been designed to assess possible negative effects of identification methods of newborn mice on their development and wellbeing. In the present study, three different identification methods were applied to newborn C57BL/6J mice on postnatal day ( pnd) 5 (toe clipping, toe tattoo ink puncture and subcutaneous implantation of a small transponder). All identification methods used proved to be effective for long-term marking of individual animals. Newborn mice showed the least reaction to toe clipping followed by toe tattoo ink puncture and transponder implantation was the most distressful individual identification procedure in newborn mice. Importantly, clipped toe tissue proved to be enough for genotyping purposes. No overall consistent differences in somatic and neurological reflex development during the postnatal period were shown as a result of the newborn individual identification procedures used. Further, none of the methods interfered significantly with the adult animals' general normal behaviour (e.g. ability to move, grasp, climb) and sensory -motor functions as assessed with a simplified SHIRPA battery of tests, as well as Rotarod and Elevated Plus Maze tests. Postmortem thymus and adrenal gland weights gave no indication of chronic stress as a consequence of the identification method. We conclude that toe clipping might even be advisable in newborn mice at a very young age, when genotyping is needed. Toe tattoo ink puncture is also a good identification method for newborn mice and transponder implantation should only be used in older newborns or applied at weaning.

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“…body temperature) without disturbing the animals presents another advantage of this identification technique. 19,21 However, this identification method requires specific equipment and transponders that may be costly, even though they can be reused.…”

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Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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“…For example, high fever often provokes seizures in children. Some studies in recent years have revealed that excitotoxic brain damage and hypoxic hippocampal damage are associated with changes in brain temperature [37]. Experimental studies have demonstrated that electrophysiological epileptiform activity increases as temperature rises, whereas hypothermia reduces ictal discharges.…”

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confidence: 99%

Effects of Propofol on Epileptiform Activity and Hippocampal Morphology in Febrile Convulsions and Pilocarpine Induced Seizures

Bican¹

2012

J Clinic Experiment Pathol

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Epidemiological and recent prospective analyses of long Febrile Seizures (FS) support the idea that such seizures can provoke Temporal Lobe Epilepsy (TLE) in some children. Because of the high prevalence of these seizures, if epilepsy was to arise as their direct consequence, this would constitute a significant clinical problem. Animal studies have revealed that exposure of hippocampal neurons to FS early in life, particularly prolonged or frequently repetitive FS, or together with brain malformation, may lead to sustained dysfunction of these cells including long-term memory impairment or epileptogenesis, in spite of the absence of neuronal damage. We established a hyperthermia model of febrile convulsions in young adult rats, and studied the effects of propofol treatment general anesthetic acting via GABA-A receptor on epileptiform activity and the morphological features of medial temporal lobe.We found statistically significant neuronal losses in the CA1, CA3 and dentate gyrus regions of hyperthermiaapplied rats as compared to the control rats. We also observed that propofol administration suppressed epileptic discharges in EEG and prevented clinical seizures behaviors. It took a median of 11 (range, 6-40) minutes for propofol to stop seizures. We conclude that prevention of epilepsy-related damage can be achieved via epileptogenesis-based clinical approaches, and that propofol is an effective agent in the hyperthermia-induced status epilepticus model.

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“…To date, the strain-dependent differences in warm air stream-induced eFS susceptibility have been reported in mice (29) but not in rats.…”

Section: Animal Models Of Fsmentioning

confidence: 99%

Novel Etiological and Therapeutic Strategies for Neurodiseases: Mechanisms and Consequences of Febrile Seizures: Lessons From Animal Models

Koyama

Matsuki

2010

J Pharmacol Sci

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Abstract. Febrile seizures (FS) are the most common type of convulsive events in infancy and childhood. Genetic and environmental elements have been suggested to contribute to FS. FS can be divided into simple and complex types, the former being benign, whereas it is controversial whether complex FS have an association with the development of temporal lobe epilepsy (TLE) in later life. In the hippocampus of TLE patients, several structural and functional alterations take place that render the region an epileptic foci. Thus, it is important to clarify the cellular and molecular changes in the hippocampus after FS and to determine whether they are epileptogenic. To achieve this goal, human studies are too limited because the sample tissues are only available from adult patients in the advanced and drug-resistant stages of the disease, masking the underlying etiology. These facts have inspired researchers to take advantage of well-established animal models of FS to answer the following questions: 1) How does hyperthermia induce FS? 2) Do FS induce neuroanatomical changes? 3) Do FS induce neurophysiological changes? 4) Do FS affect the behavior in later life? Here we introduce and discuss accumulating reports to answer these questions.

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Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains

Cited by 43 publications

References 34 publications

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Effects of Propofol on Epileptiform Activity and Hippocampal Morphology in Febrile Convulsions and Pilocarpine Induced Seizures

Novel Etiological and Therapeutic Strategies for Neurodiseases: Mechanisms and Consequences of Febrile Seizures: Lessons From Animal Models

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