Characterization of extracted phenolics from black cumin (
 Nigella sativa
 linn), coriander seed (
 Coriandrum sativum
 L.), and fenugreek seed (
 Trigonella foenum-graecum
 )

Hameed, Saleha; Imran, Ali; Nisa, Mehrun; Arshad, Muhammad Sajid; Saeed, Farhan; Arshad, Muhammad Umair; Khan, Muhammad Asif

doi:10.1080/10942912.2019.1599390

Cited by 43 publications

(37 citation statements)

References 32 publications

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“…The quantities of total phenolic compounds identified in NSS and AU extracts were in the same range as the previously reported results. For NSS methanolic and water extracts, 2.64 mg GAE/g DW and 1.67 mg GAE/g DW, respectively, were found [ 53 ]. The median value of 2.58 mg GAE/g DW identified in our study for the Romanian AU extracts was slightly higher than the one identified in the Polish AU extracts (0.7 mg GAE/g fresh weight) [ 54 ] and lower than the one identified in Montenegro and Bosnia (14.02 mg GAE/g DW) and Herzegovina (16.06 mg GAE/g DW), respectively [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Nigella sativa L. and Allium ursinum Extracts in a Cellular Model of Doxorubicin-Induced Cardiotoxicity

Pop

Bocşan

Chedea³

et al. 2020

Molecules

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Natural products black cumin—Nigella sativa (N. sativa) and wild garlic—Allium ursinum (AU) are known for their potential role in reducing cardiovascular risk factors, including antracycline chemotherapy. Therefore, this study investigates the effect of N. sativa and AU water and methanolic extracts in a cellular model of doxorubicin (doxo)-induced cardiotoxicity. The extracts were characterized using Ultraviolet-visible (UV-VIS) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, Liquid Chromatography coupled with Mass Spectrometry (LC-MS) and Gas Chromatography coupled with Mass Spectrometry (GC-MS) techniques. Antioxidant activity was evaluated on H9c2 cells. Cytosolic and mitochondrial reactive oxygen species (ROS) release was evaluated using 2′,7′-dichlorofluorescin-diacetate (DHCF-DA) and mitochondria-targeted superoxide indicator (MitoSOX red), respectively. Mitochondrial membrane depolarization was evaluated by flow cytometry. LC-MS analysis identified 12 and 10 phenolic compounds in NSS and AU extracts, respectively, with flavonols as predominant compounds. FT-IR analysis identified the presence of carbohydrates, amino acids and lipids in both plants. GC-MS identified the sulfur compounds in the AU water extract. N. sativa seeds (NSS) methanolic extract had the highest antioxidant activity reducing both intracellular and mitochondrial ROS release. All extracts (excepting AU methanolic extract) preserved H9c2 cells viability. None of the investigated plants affected the mitochondrial membrane depolarization. N. sativa and AU are important sources of bioactive compounds with increased antioxidant activities, requiring different extraction solvents to obtain the pharmacological effects.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Nigella sativa L. and Allium ursinum Extracts in a Cellular Model of Doxorubicin-Induced Cardiotoxicity

Pop

Bocşan

Chedea³

et al. 2020

Molecules

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“…Stilbenes, such as resveratrol, have been detected only in pumpkin seed (Kalogeropoulos et al., 2013; Rahman et al., 2017). Terpenes have been reported only in black cumin seed, such as thymoquinone (Hameed et al., 2019). Tyrosols, such as hydroxytyrosol and tyrosol, have only been reported in pumpkin seed (Han et al., 2019; Kalogeropoulos et al., 2013), while cimidahurinine has only been reported in perilla seed (Zhou et al., 2014).…”

Section: Polyphenols and Other Bioactives In Specialty Seedsmentioning

confidence: 99%

“…As far as we know, limited phenolic compounds (three flavonols, nine phenolic acids, and one terpene) have been reported in black cumin seed (Table 6), where the most abundant groups are flavonols (quercetin and kaempferol) and phenolic acids (chlorogenic and ferulic acids). Thymoquinone, an essential oil of terpene, is the marker for black cumin seed due to its abundant amount (Hameed et al., 2019; Mariod et al., 2009; Toma et al., 2015; Topcagic et al., 2017).…”

Section: Polyphenols and Other Bioactives In Specialty Seedsmentioning

confidence: 99%

“…As can be seen from Table 7, specialty seed antioxidant activities vary widely between assays, even within seed categories. Antioxidant activity or capacity varies between tests because of their different mechanisms of action (Barthet et al., 2014; Frassinetti et al., 2018; Hameed et al., 2019; Izzo et al., 2020; Kadam & Lele, 2017; Nawirska‐Olszańska et al., 2013; Othman et al., 2015; Paśko et al., 2009; Peiretti et al., 2017; Rahman et al., 2017; Reyes‐Caudillo et al., 2008; Sargi et al., 2013; Velioglu et al., 1998).…”

Section: Natural Antioxidants and Antioxidant Activities In Specialty Seedsmentioning

confidence: 99%

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Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

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Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.

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“…Analyses of Nigella sativa seeds showed a strong antioxidant free radical DPPH scavenging action which may be attributed to the high levels of phenolic and avonoid constituents. Similarly, Adetuyi and Ibrahim 70 , Hameed et al 71 , Hirose et al 72 and Zhang et al 73 found the DPPH function associated with the phenolic and avanoid components.…”

Section: Discussionmentioning

confidence: 83%

The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

Mahmoud¹,

Almallah

El-Hak

et al. 2020

Preprint

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This experiment aimed to investigate the effect of dietary Nigella sativa on cell mediated immune response. A total of eighteen male Wistar rats were divided equally into control and black seeds at 30 and 50 g/kg/diet (Sa30 and Sa50), respectively for 30 days. Weight gain, feed intake, feed conversion ratio (FCR), cell mediated immune response was monitored after injection of 0.1 mL of 10% phytohemagglutinin (PHA). Intumesce Index, serum total antioxidant capacity (TAC), Catalase (CAT), Interleukin-12 (IL-12), gamma interferon (γ-IF) and tumor necrosis factor alpha (TNF-α) were determined. Histopathological examination and immunohistochemistry of splenic caspase-3 and CD 8 were done. Nigella sativa significantly (p<0.05) improved weight gain and FCR in Sa30 and Sa50 groups. Significant increase for Intumesce Index in Sa50 group was observed. Total TAC, CAT, IL-12, γ-IF and TNF-αincreased significantly (P<0.05) in Sa30 and Sa50 groups. Histological examination of PHA stimulated foot pads showed more leukocytes infiltration and edema in a dose dependent pattern. Splenic caspase-3 and CD 8 showed significant (P<0.05) decrease and increase, respectively in Sa30 and Sa50 groups. Nigella sativa seeds had immunostimulatory ability through their antioxidant potential, cytokines induction, CD 8 promotion and reducing splenic apoptosis.

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Characterization of extracted phenolics from black cumin ( Nigella sativa linn), coriander seed ( Coriandrum sativum L.), and fenugreek seed ( Trigonella foenum-graecum )

Abstract: View related articles View Crossmark data Citing articles: 2 View citing articles Characterization of extracted phenolics from black cumin (Nigella sativa linn), coriander seed (Coriandrum sativum L.), and fenugreek seed (Trigonella foenum-graecum

Cited by 43 publications

References 32 publications

Evaluation of the Antioxidant Activity of Nigella sativa L. and Allium ursinum Extracts in a Cellular Model of Doxorubicin-Induced Cardiotoxicity

Evaluation of the Antioxidant Activity of Nigella sativa L. and Allium ursinum Extracts in a Cellular Model of Doxorubicin-Induced Cardiotoxicity

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

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